ID   SOSSC_CHICK             Reviewed;         103 AA.
AC   Q5ZJ32;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 63.
DE   RecName: Full=SOSS complex subunit C;
DE   AltName: Full=INTS3- and NABP-interacting protein;
DE   AltName: Full=Sensor of single-strand DNA complex subunit C;
DE   AltName: Full=Sensor of ssDNA subunit C;
DE            Short=SOSS-C;
DE   AltName: Full=Single-stranded DNA-binding protein-interacting protein 1;
DE            Short=SSB-interacting protein 1;
GN   Name=INIP; Synonyms=SSBIP1; ORFNames=RCJMB04_21d4;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
CC   -!- FUNCTION: Component of the SOSS complex, a multiprotein complex that
CC       functions downstream of the MRN complex to promote DNA repair and G2/M
CC       checkpoint. The SOSS complex associates with single-stranded DNA at DNA
CC       lesions and influences diverse endpoints in the cellular DNA damage
CC       response including cell-cycle checkpoint activation, recombinational
CC       repair and maintenance of genomic stability. Required for efficient
CC       homologous recombination-dependent repair of double-strand breaks
CC       (DSBs) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator. Component of
CC       the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1),
CC       SOSS-A/INTS3 and SOSS-C/INIP (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Localizes to nuclear
CC       foci following DNA damage. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SOSS-C family. {ECO:0000305}.
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DR   EMBL; AJ720602; CAG32261.1; -; mRNA.
DR   RefSeq; NP_001006585.1; NM_001006585.1.
DR   AlphaFoldDB; Q5ZJ32; -.
DR   SMR; Q5ZJ32; -.
DR   STRING; 9031.ENSGALP00000032142; -.
DR   PaxDb; Q5ZJ32; -.
DR   GeneID; 427331; -.
DR   KEGG; gga:427331; -.
DR   CTD; 58493; -.
DR   VEuPathDB; HostDB:geneid_427331; -.
DR   eggNOG; ENOG502S23S; Eukaryota.
DR   InParanoid; Q5ZJ32; -.
DR   PhylomeDB; Q5ZJ32; -.
DR   PRO; PR:Q5ZJ32; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0070876; C:SOSS complex; ISS:UniProtKB.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   GO; GO:0006281; P:DNA repair; ISS:UniProtKB.
DR   GO; GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
DR   InterPro; IPR031821; SOSSC.
DR   PANTHER; PTHR31526; PTHR31526; 1.
DR   Pfam; PF15925; SOSSC; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Nucleus; Reference proteome.
FT   CHAIN           1..103
FT                   /note="SOSS complex subunit C"
FT                   /id="PRO_0000279421"
SQ   SEQUENCE   103 AA;  11292 MW;  9AB23B814B746838 CRC64;
     MAANPSGQGF QNKNRVAILA ELQEKRKLLM QNQSSTNHPG ASIALARSPL NKDFRDHAEQ
     QHIAAQQKAA LQHAHAHSSG YFITQDSAFG NLILPVLPRL EAE