SOSSC_DANRE
ID SOSSC_DANRE Reviewed; 103 AA.
AC Q7ZV26;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 81.
DE RecName: Full=SOSS complex subunit C;
DE AltName: Full=INTS3- and NABP-interacting protein;
DE AltName: Full=Sensor of single-strand DNA complex subunit C;
DE AltName: Full=Sensor of ssDNA subunit C;
DE Short=SOSS-C;
DE AltName: Full=Single-stranded DNA-binding protein-interacting protein 1;
DE Short=SSB-interacting protein 1;
GN Name=inip; Synonyms=ssbip1; ORFNames=zgc:56259;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=SJD; TISSUE=Embryo;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the SOSS complex, a multiprotein complex that
CC functions downstream of the MRN complex to promote DNA repair and G2/M
CC checkpoint. The SOSS complex associates with single-stranded DNA at DNA
CC lesions and influences diverse endpoints in the cellular DNA damage
CC response including cell-cycle checkpoint activation, recombinational
CC repair and maintenance of genomic stability. Required for efficient
CC homologous recombination-dependent repair of double-strand breaks
CC (DSBs) (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Belongs to the multiprotein complex Integrator. Component of
CC the SOSS complex, composed of soss-b (soss-b1/nabp2 or soss-b2/nabp1),
CC soss-a/ints3 and soss-c/inip (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Localizes to nuclear
CC foci following DNA damage. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the SOSS-C family. {ECO:0000305}.
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DR EMBL; BC046030; AAH46030.1; -; mRNA.
DR EMBL; BC071348; AAH71348.1; -; mRNA.
DR RefSeq; NP_956513.1; NM_200219.1.
DR AlphaFoldDB; Q7ZV26; -.
DR SMR; Q7ZV26; -.
DR STRING; 7955.ENSDARP00000038879; -.
DR PaxDb; Q7ZV26; -.
DR PRIDE; Q7ZV26; -.
DR Ensembl; ENSDART00000039145; ENSDARP00000038879; ENSDARG00000028523.
DR GeneID; 393188; -.
DR KEGG; dre:393188; -.
DR CTD; 58493; -.
DR ZFIN; ZDB-GENE-040426-961; inip.
DR eggNOG; ENOG502S23S; Eukaryota.
DR GeneTree; ENSGT00390000006366; -.
DR HOGENOM; CLU_145773_1_0_1; -.
DR InParanoid; Q7ZV26; -.
DR OMA; DCKVLTN; -.
DR OrthoDB; 1596201at2759; -.
DR PhylomeDB; Q7ZV26; -.
DR TreeFam; TF328613; -.
DR PRO; PR:Q7ZV26; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 10.
DR Bgee; ENSDARG00000028523; Expressed in early embryo and 26 other tissues.
DR GO; GO:0005654; C:nucleoplasm; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0070876; C:SOSS complex; ISS:UniProtKB.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR GO; GO:0006281; P:DNA repair; ISS:UniProtKB.
DR GO; GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
DR InterPro; IPR031821; SOSSC.
DR PANTHER; PTHR31526; PTHR31526; 1.
DR Pfam; PF15925; SOSSC; 1.
PE 3: Inferred from homology;
KW DNA damage; DNA repair; Nucleus; Reference proteome.
FT CHAIN 1..103
FT /note="SOSS complex subunit C"
FT /id="PRO_0000279422"
SQ SEQUENCE 103 AA; 11345 MW; C712232D4F8C9039 CRC64;
MAANPPGQGF QNKNRVAILA ELDKEKRRLI QSQTLNNPGA SIPLSRPAVN KEFRDQAEQQ
HIAAQQKAAL QHAHAHSSGF FITQDSSFGN LILPVLPRLD PLE
