SOSSC_MOUSE
ID SOSSC_MOUSE Reviewed; 104 AA.
AC Q3TXT3; B1AX81; B1AX82; Q3TEN1; Q8BTC7;
DT 06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=SOSS complex subunit C;
DE AltName: Full=INTS3- and NABP-interacting protein;
DE AltName: Full=Sensor of single-strand DNA complex subunit C;
DE AltName: Full=Sensor of ssDNA subunit C;
DE Short=SOSS-C;
DE AltName: Full=Single-stranded DNA-binding protein-interacting protein 1;
DE Short=SSB-interacting protein 1;
GN Name=Inip; Synonyms=Ssbip1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Embryo, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the SOSS complex, a multiprotein complex that
CC functions downstream of the MRN complex to promote DNA repair and G2/M
CC checkpoint. The SOSS complex associates with single-stranded DNA at DNA
CC lesions and influences diverse endpoints in the cellular DNA damage
CC response including cell-cycle checkpoint activation, recombinational
CC repair and maintenance of genomic stability. Required for efficient
CC homologous recombination-dependent repair of double-strand breaks
CC (DSBs) and ATM-dependent signaling pathways (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Component of the SOSS complex, composed of SOSS-B (SOSS-
CC B1/NABP2 or SOSS-B2/NABP1), SOSS-A/INTS3 and SOSS-C/INIP. SOSS
CC complexes containing SOSS-B1/NABP2 are more abundant than complexes
CC containing SOSS-B2/NABP1. Interacts with INTS3; the interaction is
CC direct (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Localizes to nuclear
CC foci following DNA damage. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3TXT3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3TXT3-2; Sequence=VSP_023425;
CC -!- SIMILARITY: Belongs to the SOSS-C family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC25075.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAE41217.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAM21913.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK004256; BAC25075.1; ALT_INIT; mRNA.
DR EMBL; AK159116; BAE34832.1; -; mRNA.
DR EMBL; AK169537; BAE41217.1; ALT_INIT; mRNA.
DR EMBL; AL806512; CAM21914.1; -; Genomic_DNA.
DR EMBL; AL806512; CAM21912.1; -; Genomic_DNA.
DR EMBL; AL806512; CAM21913.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CH466565; EDL02202.1; -; Genomic_DNA.
DR EMBL; BC116204; AAI16205.1; -; mRNA.
DR EMBL; BC116205; AAI16206.1; -; mRNA.
DR CCDS; CCDS18225.1; -. [Q3TXT3-1]
DR RefSeq; NP_001013595.1; NM_001013577.1. [Q3TXT3-1]
DR AlphaFoldDB; Q3TXT3; -.
DR SMR; Q3TXT3; -.
DR BioGRID; 211300; 1.
DR ComplexPortal; CPX-613; SOSS1 complex.
DR ComplexPortal; CPX-615; SOSS2 complex.
DR STRING; 10090.ENSMUSP00000092673; -.
DR PhosphoSitePlus; Q3TXT3; -.
DR EPD; Q3TXT3; -.
DR MaxQB; Q3TXT3; -.
DR PaxDb; Q3TXT3; -.
DR PeptideAtlas; Q3TXT3; -.
DR PRIDE; Q3TXT3; -.
DR ProteomicsDB; 261610; -. [Q3TXT3-1]
DR ProteomicsDB; 261611; -. [Q3TXT3-2]
DR Antibodypedia; 15240; 44 antibodies from 10 providers.
DR Ensembl; ENSMUST00000095063; ENSMUSP00000092673; ENSMUSG00000038544. [Q3TXT3-1]
DR Ensembl; ENSMUST00000107526; ENSMUSP00000103150; ENSMUSG00000038544. [Q3TXT3-2]
DR GeneID; 66209; -.
DR KEGG; mmu:66209; -.
DR UCSC; uc008tac.1; mouse. [Q3TXT3-1]
DR CTD; 58493; -.
DR MGI; MGI:1913459; Inip.
DR VEuPathDB; HostDB:ENSMUSG00000038544; -.
DR eggNOG; ENOG502S23S; Eukaryota.
DR GeneTree; ENSGT00390000006366; -.
DR InParanoid; Q3TXT3; -.
DR OMA; DCKVLTN; -.
DR OrthoDB; 1596201at2759; -.
DR PhylomeDB; Q3TXT3; -.
DR TreeFam; TF328613; -.
DR BioGRID-ORCS; 66209; 11 hits in 109 CRISPR screens.
DR PRO; PR:Q3TXT3; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; Q3TXT3; protein.
DR Bgee; ENSMUSG00000038544; Expressed in animal zygote and 232 other tissues.
DR ExpressionAtlas; Q3TXT3; baseline and differential.
DR Genevisible; Q3TXT3; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0035861; C:site of double-strand break; ISO:MGI.
DR GO; GO:0070876; C:SOSS complex; ISS:UniProtKB.
DR GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR GO; GO:0006281; P:DNA repair; ISS:UniProtKB.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; ISO:MGI.
DR GO; GO:0044818; P:mitotic G2/M transition checkpoint; ISO:MGI.
DR GO; GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
DR InterPro; IPR031821; SOSSC.
DR PANTHER; PTHR31526; PTHR31526; 1.
DR Pfam; PF15925; SOSSC; 1.
PE 3: Inferred from homology;
KW Acetylation; Alternative splicing; DNA damage; DNA repair; Nucleus;
KW Phosphoprotein; Reference proteome.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:Q9NRY2"
FT CHAIN 2..104
FT /note="SOSS complex subunit C"
FT /id="PRO_0000279420"
FT MOD_RES 2
FT /note="N-acetylalanine"
FT /evidence="ECO:0000250|UniProtKB:Q9NRY2"
FT MOD_RES 50
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9NRY2"
FT VAR_SEQ 1..30
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_023425"
SQ SEQUENCE 104 AA; 11411 MW; 714268882CD059AF CRC64;
MAANPSGQGF QNKNRVAILA ELDKEKRKLL MQNQSSTSHP GASISLSRPS LTKDFRDHAE
QQHIAAQQKA ALQHAHAHSS GYFITQDSAF GNLILPVLPR LDPE
