ID   SOSSC_SALSA             Reviewed;         107 AA.
AC   B9EQ30;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 1.
DT   03-AUG-2022, entry version 28.
DE   RecName: Full=SOSS complex subunit C;
DE   AltName: Full=INTS3- and NABP-interacting protein;
DE   AltName: Full=Sensor of single-strand DNA complex subunit C;
DE   AltName: Full=Sensor of ssDNA subunit C;
DE            Short=SOSS-C;
DE   AltName: Full=Single-stranded DNA-binding protein-interacting protein 1;
DE            Short=SSB-interacting protein 1;
GN   Name=inip; Synonyms=ssbip1;
OS   Salmo salar (Atlantic salmon).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Salmo.
OX   NCBI_TaxID=8030;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Thymus;
RX   PubMed=20433749; DOI=10.1186/1471-2164-11-279;
RA   Leong J.S., Jantzen S.G., von Schalburg K.R., Cooper G.A., Messmer A.M.,
RA   Liao N.Y., Munro S., Moore R., Holt R.A., Jones S.J., Davidson W.S.,
RA   Koop B.F.;
RT   "Salmo salar and Esox lucius full-length cDNA sequences reveal changes in
RT   evolutionary pressures on a post-tetraploidization genome.";
RL   BMC Genomics 11:279-279(2010).
CC   -!- FUNCTION: Component of the SOSS complex, a multiprotein complex that
CC       functions downstream of the MRN complex to promote DNA repair and G2/M
CC       checkpoint. The SOSS complex associates with single-stranded DNA at DNA
CC       lesions and influences diverse endpoints in the cellular DNA damage
CC       response including cell-cycle checkpoint activation, recombinational
CC       repair and maintenance of genomic stability. Required for efficient
CC       homologous recombination-dependent repair of double-strand breaks
CC       (DSBs) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator. Component of
CC       the SOSS complex, composed of soss-b (soss-b1/nabp2 or soss-b2/nabp1),
CC       soss-a/ints3 and soss-c/inip (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Localizes to nuclear
CC       foci following DNA damage. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SOSS-C family. {ECO:0000305}.
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DR   EMBL; BT057755; ACM09627.1; -; mRNA.
DR   RefSeq; NP_001140092.1; NM_001146620.1.
DR   RefSeq; XP_014002857.1; XM_014147382.1.
DR   RefSeq; XP_014002866.1; XM_014147391.1.
DR   AlphaFoldDB; B9EQ30; -.
DR   SMR; B9EQ30; -.
DR   STRING; 8030.ENSSSAP00000047928; -.
DR   GeneID; 100286680; -.
DR   KEGG; sasa:100286680; -.
DR   CTD; 58493; -.
DR   Proteomes; UP000087266; Chromosome ssa01.
DR   Bgee; ENSSSAG00000048571; Expressed in ovary and 15 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0070876; C:SOSS complex; ISS:UniProtKB.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   GO; GO:0006281; P:DNA repair; ISS:UniProtKB.
DR   GO; GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
DR   InterPro; IPR031821; SOSSC.
DR   PANTHER; PTHR31526; PTHR31526; 1.
DR   Pfam; PF15925; SOSSC; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Nucleus; Reference proteome.
FT   CHAIN           1..107
FT                   /note="SOSS complex subunit C"
FT                   /id="PRO_0000385317"
SQ   SEQUENCE   107 AA;  11596 MW;  78F14FBC323E75A7 CRC64;
     MASPAPGAGF QNKNRVAILA ELDKEKRRLI QNSSMNNPGA SIPLSRPALN KDFRDHAEQQ
     HIAAQQKAAL QHAHAHSSGF FITQDSSFGN LILPVLPRLD PPPPAES