ID   SOSSC_TAEGU             Reviewed;         104 AA.
AC   B5KFM4; B5G3W4;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   14-OCT-2008, sequence version 1.
DT   25-MAY-2022, entry version 51.
DE   RecName: Full=SOSS complex subunit C;
DE   AltName: Full=INTS3- and NABP-interacting protein;
DE   AltName: Full=Sensor of single-strand DNA complex subunit C;
DE   AltName: Full=Sensor of ssDNA subunit C;
DE            Short=SOSS-C;
DE   AltName: Full=Single-stranded DNA-binding protein-interacting protein 1;
DE            Short=SSB-interacting protein 1;
GN   Name=INIP; Synonyms=SSBIP1;
OS   Taeniopygia guttata (Zebra finch) (Poephila guttata).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Passeriformes; Passeroidea; Estrildidae;
OC   Estrildinae; Taeniopygia.
OX   NCBI_TaxID=59729;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=17018643; DOI=10.1073/pnas.0607098103;
RA   Wada K., Howard J.T., McConnell P., Whitney O., Lints T., Rivas M.V.,
RA   Horita H., Patterson M.A., White S.A., Scharff C., Haesler S., Zhao S.,
RA   Sakaguchi H., Hagiwara M., Shiraki T., Hirozane-Kishikawa T., Skene P.,
RA   Hayashizaki Y., Carninci P., Jarvis E.D.;
RT   "A molecular neuroethological approach for identifying and characterizing a
RT   cascade of behaviorally regulated genes.";
RL   Proc. Natl. Acad. Sci. U.S.A. 103:15212-15217(2006).
CC   -!- FUNCTION: Component of the SOSS complex, a multiprotein complex that
CC       functions downstream of the MRN complex to promote DNA repair and G2/M
CC       checkpoint. The SOSS complex associates with single-stranded DNA at DNA
CC       lesions and influences diverse endpoints in the cellular DNA damage
CC       response including cell-cycle checkpoint activation, recombinational
CC       repair and maintenance of genomic stability. Required for efficient
CC       homologous recombination-dependent repair of double-strand breaks
CC       (DSBs) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator. Component of
CC       the SOSS complex, composed of SOSS-B (SOSS-B1/NABP2 or SOSS-B2/NABP1),
CC       SOSS-A/INTS3 and SOSS-C/INIP (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Localizes to nuclear
CC       foci following DNA damage. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SOSS-C family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ACH45975.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; EF191823; ACH46372.1; -; mRNA.
DR   EMBL; DQ216884; ACH45975.1; ALT_FRAME; mRNA.
DR   RefSeq; NP_001184184.1; NM_001197255.1.
DR   AlphaFoldDB; B5KFM4; -.
DR   SMR; B5KFM4; -.
DR   STRING; 59729.ENSTGUP00000001286; -.
DR   Ensembl; ENSTGUT00000001298; ENSTGUP00000001286; ENSTGUG00000001248.
DR   GeneID; 100190500; -.
DR   KEGG; tgu:100190500; -.
DR   CTD; 58493; -.
DR   GeneTree; ENSGT00390000006366; -.
DR   HOGENOM; CLU_145773_1_0_1; -.
DR   InParanoid; B5KFM4; -.
DR   OMA; DCKVLTN; -.
DR   OrthoDB; 1596201at2759; -.
DR   TreeFam; TF328613; -.
DR   Proteomes; UP000007754; Chromosome Z.
DR   GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0035861; C:site of double-strand break; IEA:Ensembl.
DR   GO; GO:0070876; C:SOSS complex; ISS:UniProtKB.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   GO; GO:0006281; P:DNA repair; ISS:UniProtKB.
DR   GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:Ensembl.
DR   GO; GO:0044818; P:mitotic G2/M transition checkpoint; IEA:Ensembl.
DR   GO; GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
DR   InterPro; IPR031821; SOSSC.
DR   PANTHER; PTHR31526; PTHR31526; 1.
DR   Pfam; PF15925; SOSSC; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Nucleus; Reference proteome.
FT   CHAIN           1..104
FT                   /note="SOSS complex subunit C"
FT                   /id="PRO_0000385316"
SQ   SEQUENCE   104 AA;  11437 MW;  185CCFC8D8107378 CRC64;
     MAANPSGQGF QNKNRVAILA ELDKEKRKLL MQNQSSTNHP GASIALTRSP LNKDFRDHAE
     QQHIAAQQKA ALQHAHAHSS GYFITQDSAF GNLILPVLPR LEAE