ID   SOSSC_XENLA             Reviewed;         110 AA.
AC   Q8AVV6;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   03-AUG-2022, entry version 46.
DE   RecName: Full=SOSS complex subunit C;
DE   AltName: Full=Sensor of single-strand DNA complex subunit C;
DE   AltName: Full=Sensor of ssDNA subunit C;
DE            Short=SOSS-C;
DE   AltName: Full=Single-stranded DNA-binding protein-interacting protein 1;
DE            Short=SSB-interacting protein 1;
GN   Name=inip; Synonyms=ssbip1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the SOSS complex, a multiprotein complex that
CC       functions downstream of the MRN complex to promote DNA repair and G2/M
CC       checkpoint. The SOSS complex associates with single-stranded DNA at DNA
CC       lesions and influences diverse endpoints in the cellular DNA damage
CC       response including cell-cycle checkpoint activation, recombinational
CC       repair and maintenance of genomic stability. Required for efficient
CC       homologous recombination-dependent repair of double-strand breaks
CC       (DSBs) (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Belongs to the multiprotein complex Integrator. Component of
CC       the SOSS complex, composed of soss-b (soss-b1/nabp2 or soss-b2/nabp1),
CC       soss-a/ints3 and soss-c/inip (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Note=Localizes to nuclear
CC       foci following DNA damage. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SOSS-C family. {ECO:0000305}.
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DR   EMBL; BC041246; AAH41246.1; -; mRNA.
DR   RefSeq; NP_001079381.1; NM_001085912.1.
DR   AlphaFoldDB; Q8AVV6; -.
DR   SMR; Q8AVV6; -.
DR   DNASU; 379068; -.
DR   GeneID; 379068; -.
DR   KEGG; xla:379068; -.
DR   CTD; 379068; -.
DR   Xenbase; XB-GENE-988718; inip.S.
DR   OrthoDB; 1596201at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 379068; Expressed in gastrula and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0070876; C:SOSS complex; ISS:UniProtKB.
DR   GO; GO:0006974; P:cellular response to DNA damage stimulus; ISS:UniProtKB.
DR   GO; GO:0006281; P:DNA repair; ISS:UniProtKB.
DR   GO; GO:0010212; P:response to ionizing radiation; ISS:UniProtKB.
DR   InterPro; IPR031821; SOSSC.
DR   PANTHER; PTHR31526; PTHR31526; 1.
DR   Pfam; PF15925; SOSSC; 1.
PE   3: Inferred from homology;
KW   DNA damage; DNA repair; Nucleus; Reference proteome.
FT   CHAIN           1..110
FT                   /note="SOSS complex subunit C"
FT                   /id="PRO_0000279423"
SQ   SEQUENCE   110 AA;  11972 MW;  4686206DEE163C71 CRC64;
     MDPGSTASPL QCTAGFPSKN RVAILAELDK EKRKLLLQNQ SSTNNPGASI ALARPNMNKD
     FRDHSEQQHI AAQQKAALQH AHAHSSGYFI TQDSAFGNLI LPVIPRLEAE