SOS_DROME
ID SOS_DROME Reviewed; 1596 AA.
AC P26675; Q6AWF4; Q8I067; Q8I0F7; Q8ITK2; Q95TI8; Q969D6; Q9VJV9;
DT 01-AUG-1992, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 2.
DT 03-AUG-2022, entry version 205.
DE RecName: Full=Protein son of sevenless;
GN Name=Sos; ORFNames=CG7793;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=Oregon-R; TISSUE=Imaginal disk;
RX PubMed=1736363; DOI=10.1126/science.1736363;
RA Bonfini L., Karlovich C.A., Dasgupta C., Banerjee U.;
RT "The Son of sevenless gene product: a putative activator of Ras.";
RL Science 255:603-606(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND FUNCTION.
RX PubMed=1934068; DOI=10.1016/0092-8674(91)90065-7;
RA Simon M.A., Bowtell D.D.L., Dodson G.S., Laverty T.R., Rubin G.M.;
RT "Ras1 and a putative guanine nucleotide exchange factor perform crucial
RT steps in signaling by the sevenless protein tyrosine kinase.";
RL Cell 67:701-716(1991).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10471707; DOI=10.1093/genetics/153.1.179;
RA Ashburner M., Misra S., Roote J., Lewis S.E., Blazej R.G., Davis T.,
RA Doyle C., Galle R.F., George R.A., Harris N.L., Hartzell G., Harvey D.A.,
RA Hong L., Houston K.A., Hoskins R.A., Johnson G., Martin C., Moshrefi A.R.,
RA Palazzolo M., Reese M.G., Spradling A.C., Tsang G., Wan K.H., Whitelaw K.,
RA Celniker S.E., Rubin G.M.;
RT "An exploration of the sequence of a 2.9-Mb region of the genome of
RT Drosophila melanogaster: the Adh region.";
RL Genetics 153:179-219(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [5]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Head;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Pacleb J.M.,
RA Park S., Wan K.H., Yu C., Rubin G.M., Celniker S.E.;
RL Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1148-1596.
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [8]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1240-1582.
RC STRAIN=In_L003, In_L004, In_L012, In_L018, In_L019, In_L021, In_L031,
RC In_L035, In_L101, St_L005, St_L013, St_L027, St_L028, St_L033, St_L037,
RC St_L106, St_L111, St_L120, St_L124, and St_L127;
RX PubMed=12618399; DOI=10.1093/genetics/163.2.599;
RA Mousset S., Brazier L., Cariou M.L., Chartois F., Depaulis F., Veuille M.;
RT "Evidence of a high rate of selective sweeps in African Drosophila
RT melanogaster.";
RL Genetics 163:599-609(2003).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1550 AND SER-1551, AND
RP IDENTIFICATION BY MASS SPECTROMETRY.
RC TISSUE=Embryo;
RX PubMed=18327897; DOI=10.1021/pr700696a;
RA Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.;
RT "Phosphoproteome analysis of Drosophila melanogaster embryos.";
RL J. Proteome Res. 7:1675-1682(2008).
RN [10]
RP STRUCTURE BY NMR OF 1342-1351.
RX PubMed=7773779; DOI=10.1038/nsb1294-898;
RA Goudreau N., Cornille F., Duchesne M., Parker F., Tocque B., Garbay C.,
RA Roques B.P.;
RT "NMR structure of the N-terminal SH3 domain of GRB2 and its complex with a
RT proline-rich peptide from Sos.";
RL Nat. Struct. Biol. 1:898-907(1994).
CC -!- FUNCTION: Promotes the exchange of Ras-bound GDP by GTP. Functions in
CC signaling pathways initiated by the sevenless and epidermal growth
CC factor receptor tyrosine kinases; implies a role for the ras pathway in
CC neuronal development. {ECO:0000269|PubMed:1736363,
CC ECO:0000269|PubMed:1934068}.
CC -!- SUBUNIT: May form a complex with sevenless and DRK.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL13978.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; M83931; AAB04680.1; -; mRNA.
DR EMBL; M77501; AAA28904.1; -; Genomic_DNA.
DR EMBL; AE014134; AAF53336.2; -; Genomic_DNA.
DR EMBL; BT015294; AAT94523.1; -; mRNA.
DR EMBL; AY058749; AAL13978.1; ALT_INIT; mRNA.
DR EMBL; AF459566; AAN61382.1; -; Genomic_DNA.
DR EMBL; AF459567; AAN61383.1; -; Genomic_DNA.
DR EMBL; AF459568; AAN61384.1; -; Genomic_DNA.
DR EMBL; AF459569; AAN61385.1; -; Genomic_DNA.
DR EMBL; AF459570; AAN61386.1; -; Genomic_DNA.
DR EMBL; AF459571; AAN61387.1; -; Genomic_DNA.
DR EMBL; AF459572; AAN61388.1; -; Genomic_DNA.
DR EMBL; AF459573; AAN61389.1; -; Genomic_DNA.
DR EMBL; AF459574; AAN61390.1; -; Genomic_DNA.
DR EMBL; AF459575; AAN61391.1; -; Genomic_DNA.
DR EMBL; AF459576; AAN61392.1; -; Genomic_DNA.
DR EMBL; AF459577; AAN61393.1; -; Genomic_DNA.
DR EMBL; AF459578; AAN61394.1; -; Genomic_DNA.
DR EMBL; AF459579; AAN61395.1; -; Genomic_DNA.
DR EMBL; AF459580; AAN61396.1; -; Genomic_DNA.
DR EMBL; AF459581; AAN61397.1; -; Genomic_DNA.
DR EMBL; AF459582; AAN61398.1; -; Genomic_DNA.
DR EMBL; AF459583; AAN61399.1; -; Genomic_DNA.
DR EMBL; AF459584; AAN61400.1; -; Genomic_DNA.
DR EMBL; AF459585; AAN61401.1; -; Genomic_DNA.
DR PIR; A41216; A41216.
DR RefSeq; NP_476597.2; NM_057249.6.
DR PDB; 1AZE; NMR; -; B=1342-1350.
DR PDBsum; 1AZE; -.
DR AlphaFoldDB; P26675; -.
DR SMR; P26675; -.
DR BioGRID; 60823; 41.
DR DIP; DIP-22308N; -.
DR IntAct; P26675; 12.
DR STRING; 7227.FBpp0080118; -.
DR iPTMnet; P26675; -.
DR PaxDb; P26675; -.
DR PRIDE; P26675; -.
DR EnsemblMetazoa; FBtr0080541; FBpp0080118; FBgn0001965.
DR GeneID; 34790; -.
DR KEGG; dme:Dmel_CG7793; -.
DR CTD; 34790; -.
DR FlyBase; FBgn0001965; Sos.
DR VEuPathDB; VectorBase:FBgn0001965; -.
DR eggNOG; KOG3417; Eukaryota.
DR HOGENOM; CLU_002744_2_0_1; -.
DR InParanoid; P26675; -.
DR OMA; PPPFEWH; -.
DR OrthoDB; 576110at2759; -.
DR PhylomeDB; P26675; -.
DR Reactome; R-DME-112412; SOS-mediated signalling.
DR Reactome; R-DME-1250347; SHC1 events in ERBB4 signaling.
DR Reactome; R-DME-167044; Signalling to RAS.
DR Reactome; R-DME-179812; GRB2 events in EGFR signaling.
DR Reactome; R-DME-180336; SHC1 events in EGFR signaling.
DR Reactome; R-DME-186763; Downstream signal transduction.
DR Reactome; R-DME-193648; NRAGE signals death through JNK.
DR Reactome; R-DME-1963640; GRB2 events in ERBB2 signaling.
DR Reactome; R-DME-210993; Tie2 Signaling.
DR Reactome; R-DME-2179392; EGFR Transactivation by Gastrin.
DR Reactome; R-DME-2424491; DAP12 signaling.
DR Reactome; R-DME-2428933; SHC-related events triggered by IGF1R.
DR Reactome; R-DME-2730905; Role of LAT2/NTAL/LAB on calcium mobilization.
DR Reactome; R-DME-2871796; FCERI mediated MAPK activation.
DR Reactome; R-DME-2871809; FCERI mediated Ca+2 mobilization.
DR Reactome; R-DME-375165; NCAM signaling for neurite out-growth.
DR Reactome; R-DME-416482; G alpha (12/13) signalling events.
DR Reactome; R-DME-5654688; SHC-mediated cascade:FGFR1.
DR Reactome; R-DME-5654693; FRS-mediated FGFR1 signaling.
DR Reactome; R-DME-5654699; SHC-mediated cascade:FGFR2.
DR Reactome; R-DME-5654700; FRS-mediated FGFR2 signaling.
DR Reactome; R-DME-5654704; SHC-mediated cascade:FGFR3.
DR Reactome; R-DME-5654706; FRS-mediated FGFR3 signaling.
DR Reactome; R-DME-5654712; FRS-mediated FGFR4 signaling.
DR Reactome; R-DME-5654719; SHC-mediated cascade:FGFR4.
DR Reactome; R-DME-5673001; RAF/MAP kinase cascade.
DR Reactome; R-DME-74749; Signal attenuation.
DR Reactome; R-DME-74751; Insulin receptor signalling cascade.
DR Reactome; R-DME-9013149; RAC1 GTPase cycle.
DR Reactome; R-DME-9607240; FLT3 Signaling.
DR SignaLink; P26675; -.
DR BioGRID-ORCS; 34790; 0 hits in 3 CRISPR screens.
DR EvolutionaryTrace; P26675; -.
DR GenomeRNAi; 34790; -.
DR PRO; PR:P26675; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0001965; Expressed in wing disc and 23 other tissues.
DR ExpressionAtlas; P26675; baseline and differential.
DR Genevisible; P26675; DM.
DR GO; GO:0005829; C:cytosol; IDA:FlyBase.
DR GO; GO:0031234; C:extrinsic component of cytoplasmic side of plasma membrane; IDA:FlyBase.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0035997; C:rhabdomere microvillus membrane; IDA:FlyBase.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IDA:FlyBase.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0016199; P:axon midline choice point recognition; IGI:FlyBase.
DR GO; GO:0051607; P:defense response to virus; IMP:FlyBase.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IMP:FlyBase.
DR GO; GO:0007427; P:epithelial cell migration, open tracheal system; IMP:FlyBase.
DR GO; GO:0008543; P:fibroblast growth factor receptor signaling pathway; IMP:FlyBase.
DR GO; GO:0007480; P:imaginal disc-derived leg morphogenesis; IMP:FlyBase.
DR GO; GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle; IMP:FlyBase.
DR GO; GO:0043703; P:photoreceptor cell fate determination; IGI:FlyBase.
DR GO; GO:0045793; P:positive regulation of cell size; IMP:FlyBase.
DR GO; GO:0043547; P:positive regulation of GTPase activity; IBA:GO_Central.
DR GO; GO:0035022; P:positive regulation of Rac protein signal transduction; IGI:FlyBase.
DR GO; GO:0046579; P:positive regulation of Ras protein signal transduction; IDA:FlyBase.
DR GO; GO:0007465; P:R7 cell fate commitment; IGI:FlyBase.
DR GO; GO:0007265; P:Ras protein signal transduction; IBA:GO_Central.
DR GO; GO:0045500; P:sevenless signaling pathway; IGI:FlyBase.
DR GO; GO:0008293; P:torso signaling pathway; IMP:FlyBase.
DR GO; GO:0007426; P:tracheal outgrowth, open tracheal system; IMP:FlyBase.
DR GO; GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IMP:FlyBase.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.10.20.10; -; 1.
DR Gene3D; 1.10.840.10; -; 1.
DR Gene3D; 1.20.900.10; -; 1.
DR Gene3D; 2.30.29.30; -; 1.
DR IDEAL; IID50185; -.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR007125; Histone_H2A/H2B/H3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR PANTHER; PTHR23113; PTHR23113; 1.
DR Pfam; PF00125; Histone; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
DR SUPFAM; SSF48065; SSF48065; 1.
DR SUPFAM; SSF48366; SSF48366; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Developmental protein; Differentiation;
KW Guanine-nucleotide releasing factor; Neurogenesis; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..1596
FT /note="Protein son of sevenless"
FT /id="PRO_0000068898"
FT DOMAIN 248..434
FT /note="DH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00062"
FT DOMAIN 480..588
FT /note="PH"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00145"
FT DOMAIN 637..792
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00135"
FT DOMAIN 829..1066
FT /note="Ras-GEF"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00168"
FT REGION 1073..1105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1175..1212
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1235..1291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1340..1392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1465..1596
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1089..1105
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1175..1196
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1275..1291
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1345..1359
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1374..1388
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1469..1485
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1492..1525
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1529..1543
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1574..1596
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1550
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT MOD_RES 1551
FT /note="Phosphoserine"
FT /evidence="ECO:0000269|PubMed:18327897"
FT VARIANT 1256
FT /note="P -> L (in strain: St_L028 and St_L033)"
FT VARIANT 1322
FT /note="A -> S (in strain: In_L019)"
FT VARIANT 1503
FT /note="S -> N (in strain: In_L019)"
FT CONFLICT 15
FT /note="G -> W (in Ref. 6; AAT94523)"
FT /evidence="ECO:0000305"
FT CONFLICT 232..244
FT /note="HILPSPLSLPAQR -> TSCPVPCHFPRS (in Ref. 1)"
FT /evidence="ECO:0000305"
FT CONFLICT 523
FT /note="A -> T (in Ref. 6; AAT94523)"
FT /evidence="ECO:0000305"
FT CONFLICT 1463
FT /note="P -> V (in Ref. 1; AAB04680)"
FT /evidence="ECO:0000305"
FT CONFLICT 1468
FT /note="I -> V (in Ref. 6; AAT94523)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1596 AA; 177934 MW; 08DB85B59213B964 CRC64;
MFSGPSGHAH TISYGGGIGL GTGGGGGSGG SGSGSQGGGG GIGIGGGGVA GLQDCDGYDF
TKCENAARWR GLFTPSLKKV LEQVHPRVTA KEDALLYVEK LCLRLLAMLC AKPLPHSVQD
VEEKVNKSFP APIDQWALNE AKEVINSKKR KSVLPTEKVH TLLQKDVLQY KIDSSVSAFL
VAVLEYISAD ILKMAGDYVI KIAHCEITKE DIEVVMNADR VLMDMLNQSE AHILPSPLSL
PAQRASATYE ETVKELIHDE KQYQRDLHMI IRVFREELVK IVSDPRELEP IFSNIMDIYE
VTVTLLGSLE DVIEMSQEQS APCVGSCFEE LAEAEEFDVY KKYAYDVTSQ ASRDALNNLL
SKPGASSLTT AGHGFRDAVK YYLPKLLLVP ICHAFVYFDY IKHLKDLSSS QDDIESFEQV
QGLLHPLHCD LEKVMASLSK ERQVPVSGRV RRQLAIERTR ELQMKVEHWE DKDVGQNCNE
FIREDSLSKL GSGKRIWSER KVFLFDGLMV LCKANTKKQT PSAGATAYDY RLKEKYFMRR
VDINDRPDSD DLKNSFELAP RMQPPIVLTA KNAQHKHDWM ADLLMVITKS MLDRHLDSIL
QDIERKHPLR MPSPEIYKFA VPDSGDNIVL EERESAGVPM IKGATLCKLI ERLTYHIYAD
PTFVRTFLTT YRYFCSPQQL LQLLVERFNI PDPSLVYQDT GTAGAGGMGG VGGDKEHKNS
HREDWKRYRK EYVQPVQFRV LNVLRHWVDH HFYDFEKDPM LLEKLLNFLE HVNGKSMRKW
VDSVLKIVQR KNEQEKSNKK IVYAYGHDPP PIEHHLSVPN DEITLLTLHP LELARQLTLL
EFEMYKNVKP SELVGSPWTK KDKEVKSPNL LKIMKHTTNV TRWIEKSITE AENYEERLAI
MQRAIEVMMV MLELNNFNGI LSIVAAMGTA SVYRLRWTFQ GLPERYRKFL EECRELSDDH
LKKYQERLRS INPPCVPFFG RYLTNILHLE EGNPDLLANT ELINFSKRRK VAEIIGEIQQ
YQNQPYCLNE ESTIRQFFEQ LDPFNGLSDK QMSDYLYNES LRIEPRGCKT VPKFPRKWPH
IPLKSPGIKP RRQNQTNSSS KLSNSTSSVA AAAAASSTAT SIATASAPSL HASSIMDAPT
AAAANAGSGT LAGEQSPQHN PHAFSVFAPV IIPERNTSSW SGTPQHTRTD QNNGEVSVPA
PHLPKKPGAH VWANNNSTLA SASAMDVVFS PALPEHLPPQ SLPDSNPFAS DTEAPPSPLP
KLVVSPRHET GNRSPFHGRM QNSPTHSTAS TVTLTGMSTS GGEEFCAGGF YFNSAHQGQP
GAVPISPHVN VPMATNMEYR AVPPPLPPRR KERTESCADM AQKRQAPDAP TLPPRDGELS
PPPIPPRLNH STGISYLRQS HGKSKEFVGN SSLLLPNTSS IMIRRNSAIE KRAAATSQPN
QAAAGPISTT LVTVSQAVAT DEPLPLPISP AASSSTTTSP LTPAMSPMSP NIPSHPVEST
SSSYAHQLRM RQQQQQQTHP AIYSQHHQHH ATHLPHHPHQ HHSNPTQSRS SPKEFFPIAT
SLEGTPKLPP KPSLSANFYN NPDKGTMFLY PSTNEE
