SOT6_ARATH
ID SOT6_ARATH Reviewed; 329 AA.
AC Q9M1V1;
DT 16-MAY-2012, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Cytosolic sulfotransferase 6;
DE Short=AtSOT6;
DE EC=2.8.2.-;
DE AltName: Full=sulfotransferase 3b;
DE Short=AtST3b;
GN Name=SOT6; Synonyms=ST3B; OrderedLocusNames=At3g45080; ORFNames=T14D3.20;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Cheuk R., Chen H., Kim C.J., Shinn P., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15234990; DOI=10.1093/jxb/erh183;
RA Klein M., Papenbrock J.;
RT "The multi-protein family of Arabidopsis sulphotransferases and their
RT relatives in other plant species.";
RL J. Exp. Bot. 55:1809-1820(2004).
RN [5]
RP IDENTIFICATION, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=17095238; DOI=10.1016/j.plaphy.2006.10.004;
RA Gidda S.K., Varin L.;
RT "Biochemical and molecular characterization of flavonoid 7-sulfotransferase
RT from Arabidopsis thaliana.";
RL Plant Physiol. Biochem. 44:628-636(2006).
CC -!- FUNCTION: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate
CC (PAPS) as sulfonate donor. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the sulfotransferase 1 family. {ECO:0000305}.
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DR EMBL; AL138649; CAB72146.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77989.1; -; Genomic_DNA.
DR EMBL; BT014993; AAT70444.1; -; mRNA.
DR EMBL; BT015730; AAU45228.1; -; mRNA.
DR PIR; T47448; T47448.
DR RefSeq; NP_190094.1; NM_114377.3.
DR AlphaFoldDB; Q9M1V1; -.
DR SMR; Q9M1V1; -.
DR BioGRID; 8963; 1.
DR STRING; 3702.AT3G45080.1; -.
DR iPTMnet; Q9M1V1; -.
DR PaxDb; Q9M1V1; -.
DR PRIDE; Q9M1V1; -.
DR ProteomicsDB; 232630; -.
DR EnsemblPlants; AT3G45080.1; AT3G45080.1; AT3G45080.
DR GeneID; 823643; -.
DR Gramene; AT3G45080.1; AT3G45080.1; AT3G45080.
DR KEGG; ath:AT3G45080; -.
DR Araport; AT3G45080; -.
DR TAIR; locus:2096855; AT3G45080.
DR eggNOG; KOG1584; Eukaryota.
DR HOGENOM; CLU_027239_0_3_1; -.
DR InParanoid; Q9M1V1; -.
DR OMA; PEHILFM; -.
DR OrthoDB; 780670at2759; -.
DR PhylomeDB; Q9M1V1; -.
DR BioCyc; ARA:AT3G45080-MON; -.
DR PRO; PR:Q9M1V1; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9M1V1; baseline and differential.
DR Genevisible; Q9M1V1; AT.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0008146; F:sulfotransferase activity; IBA:GO_Central.
DR GO; GO:0051923; P:sulfation; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000863; Sulfotransferase_dom.
DR Pfam; PF00685; Sulfotransfer_1; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome; Transferase.
FT CHAIN 1..329
FT /note="Cytosolic sulfotransferase 6"
FT /id="PRO_0000417054"
FT ACT_SITE 140
FT /note="Proton acceptor"
FT /evidence="ECO:0000250"
FT BINDING 74..79
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000250"
FT BINDING 162
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000250"
FT BINDING 170
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000250"
FT BINDING 295..297
FT /ligand="3'-phosphoadenylyl sulfate"
FT /ligand_id="ChEBI:CHEBI:58339"
FT /evidence="ECO:0000250"
SQ SEQUENCE 329 AA; 38069 MW; 9D04227A483A630C CRC64;
MDEKKITMNV RNDELSEESK TLISSLPSDK NSTGVNVCKY QGCWYTPPIL QGVLNFQKNF
KPQDTDIIVA SFPKCGTTWL KALTFALVRR SKHPSHDDHH PLLSDNPHVL SPSLEMYLYL
CSENPDLTKF SSSSRLFSTH MPSHTLQEGL KGSTCKIVYM SRNVKDTLVS YWHFFCKKQT
DDNIISSVED TFEMFCRGVN FFGPFWDHVL SYWRGSLEDP NHVLFMKFEE MKEEPREQIK
RLAEFLGCLF TKEEEESGLV DEIIDLCSLR NLSSLEINKT GKLHSTGREN KTFFRKGEVG
DWKNYLTPEM ENKIDMIIQE KLQNSGLKF
