ID   SOTA_DICCH              Reviewed;         393 AA.
AC   Q9S3K0;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 79.
DE   RecName: Full=Sugar efflux transporter A;
GN   Name=sotA;
OS   Dickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Dickeya.
OX   NCBI_TaxID=556;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND CHARACTERIZATION.
RC   STRAIN=A350;
RX   PubMed=10671456; DOI=10.1128/jb.182.5.1340-1345.2000;
RA   Condemine G.;
RT   "Characterization of SotA and SotB, two Erwinia chrysanthemi proteins which
RT   modify isopropyl-beta-D-thiogalactopyranoside and lactose induction of the
RT   Escherichia coli lac promoter.";
RL   J. Bacteriol. 182:1340-1345(2000).
CC   -!- FUNCTION: Involved in the efflux of sugars. The physiological role may
CC       be the reduction of the intracellular concentration of toxic sugars or
CC       sugar metabolites. Transports IPTG, lactose and arabinose.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000305}; Multi-pass
CC       membrane protein {ECO:0000305}.
CC   -!- INDUCTION: Activated by cyclic AMP receptor protein (CRP).
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. Set
CC       transporter family. {ECO:0000305}.
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DR   EMBL; AJ249180; CAB53452.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9S3K0; -.
DR   SMR; Q9S3K0; -.
DR   TCDB; 2.A.1.20.4; the major facilitator superfamily (mfs).
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005351; F:carbohydrate:proton symporter activity; IEA:InterPro.
DR   Gene3D; 1.20.1250.20; -; 2.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR004750; Sugar_efflux.
DR   PANTHER; PTHR23535:SF2; PTHR23535:SF2; 1.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   TIGRFAMs; TIGR00899; 2A0120; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Membrane; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..393
FT                   /note="Sugar efflux transporter A"
FT                   /id="PRO_0000209363"
FT   TRANSMEM        22..42
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        152..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        174..194
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        219..239
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        253..273
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        287..307
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        308..328
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        344..364
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        366..386
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   393 AA;  42428 MW;  1A47A92FE586F701 CRC64;
     MTISSARTAR RLPDLTSSAF LVIAFLTGIA GALQLPTLSL FLSTEVQVRP FMVGLFYTGS
     AVIGIVVSQI LATYSDRQGD RKTLILQCCL LGALACLLYA WNRNYFVLLF IGVLLSSFGS
     TANPQLFALA REHADRTGRG AAMFSSVMRA QISLSWVIGP PVAFALALGF GFPAMYLTAA
     VVFVLCGLLV WLLLPSMPKT RVKSAATLES PRQNRRDTLL LFTACTLMWT CNGIYLINMP
     LYLVNELRLP EKLAGVMMGT AAGLEIPVML LAGYLTSRLG KRLLMRLAVI AGLIFYTGLT
     LLNGSWALLA LQLLNAIFIG ILAGMGMLYF QDLMPGQAGA ATTLFTNTTR VGWIISGSLA
     GIVAEVWSYH AGFVIAIAML AGAAVCMWRI RDV