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SOTB_DICCH
ID   SOTB_DICCH              Reviewed;         395 AA.
AC   Q9S3J9;
DT   23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-2000, sequence version 1.
DT   25-MAY-2022, entry version 77.
DE   RecName: Full=Sugar efflux transporter B;
GN   Name=sotB;
OS   Dickeya chrysanthemi (Pectobacterium chrysanthemi) (Erwinia chrysanthemi).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Dickeya.
OX   NCBI_TaxID=556;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], CHARACTERIZATION, FUNCTION, SUBCELLULAR
RP   LOCATION, AND INDUCTION.
RC   STRAIN=A350;
RX   PubMed=10671456; DOI=10.1128/jb.182.5.1340-1345.2000;
RA   Condemine G.;
RT   "Characterization of SotA and SotB, two Erwinia chrysanthemi proteins which
RT   modify isopropyl-beta-D-thiogalactopyranoside and lactose induction of the
RT   Escherichia coli lac promoter.";
RL   J. Bacteriol. 182:1340-1345(2000).
CC   -!- FUNCTION: Involved in the efflux of sugars. The physiological role may
CC       be the reduction of the intracellular concentration of toxic sugars or
CC       sugar metabolites. Transports IPTG, lactose and melibiose.
CC       {ECO:0000269|PubMed:10671456}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000305|PubMed:10671456}; Multi-pass membrane protein
CC       {ECO:0000305|PubMed:10671456}.
CC   -!- INDUCTION: Activated by glucose, and to a lesser extent by other
CC       metabolizable sugars such as galacturonate, arabinose and melibiose.
CC       Repressed by cyclic AMP receptor protein (CRP).
CC       {ECO:0000269|PubMed:10671456}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. SotB (TC
CC       2.A.1.2) family. {ECO:0000305}.
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DR   EMBL; AJ249181; CAB53453.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9S3J9; -.
DR   SMR; Q9S3J9; -.
DR   TCDB; 2.A.1.2.18; the major facilitator superfamily (mfs).
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015144; F:carbohydrate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   HAMAP; MF_00517; MFS_SotB; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR023495; Sugar_effux_transptr_put.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   1: Evidence at protein level;
KW   Cell inner membrane; Cell membrane; Membrane; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..395
FT                   /note="Sugar efflux transporter B"
FT                   /id="PRO_0000209326"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        50..70
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        81..101
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        136..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        246..266
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..292
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        299..319
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   395 AA;  41954 MW;  759EA39D0CAF43F5 CRC64;
     MTSASPSRST AWLRVVTLAI AAFIFNTTEF IPVGLLSDIA NSFAMKTEDV GLMITIYAWI
     VAVASLICML LTSGIERRKL LIGLFSLFIL SHLLSAVAWN FTVLVISRAG VALAHSVFWS
     ITASLAIRMA PPGKRAQALG LIATGSSLAM VLGLPLGRVI GQYLGWRVTF LTIAAGATVA
     MILLARLLPL LPSEHSGSLG SVPKLFRRPA LVGIYLLTVV VVTAHFTAYS YIEPFIQTVA
     GLPENFTTLI LLLFGCAGIA GSMLYSRYSD RFPIGFLVTA MLLLLACLTL LMPLSGYPFG
     LTLLCLVWGL AMMSIGLAMQ AKVLSLAPDA SDVAMSIFSG LFNLGIGGGA LLGSQVSLHL
     GMDKIGYVGA PLVLVALFAT LLSVYRSVRL VHSRV
 
 
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