ID   SOTB_HAEIN              Reviewed;         396 AA.
AC   P44535;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Probable sugar efflux transporter {ECO:0000255|HAMAP-Rule:MF_00517};
GN   Name=sotB {ECO:0000255|HAMAP-Rule:MF_00517}; OrderedLocusNames=HI_0135;
OS   Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pasteurellales;
OC   Pasteurellaceae; Haemophilus.
OX   NCBI_TaxID=71421;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 51907 / DSM 11121 / KW20 / Rd;
RX   PubMed=7542800; DOI=10.1126/science.7542800;
RA   Fleischmann R.D., Adams M.D., White O., Clayton R.A., Kirkness E.F.,
RA   Kerlavage A.R., Bult C.J., Tomb J.-F., Dougherty B.A., Merrick J.M.,
RA   McKenney K., Sutton G.G., FitzHugh W., Fields C.A., Gocayne J.D.,
RA   Scott J.D., Shirley R., Liu L.-I., Glodek A., Kelley J.M., Weidman J.F.,
RA   Phillips C.A., Spriggs T., Hedblom E., Cotton M.D., Utterback T.R.,
RA   Hanna M.C., Nguyen D.T., Saudek D.M., Brandon R.C., Fine L.D.,
RA   Fritchman J.L., Fuhrmann J.L., Geoghagen N.S.M., Gnehm C.L., McDonald L.A.,
RA   Small K.V., Fraser C.M., Smith H.O., Venter J.C.;
RT   "Whole-genome random sequencing and assembly of Haemophilus influenzae
RT   Rd.";
RL   Science 269:496-512(1995).
CC   -!- FUNCTION: Involved in the efflux of sugars. The physiological role may
CC       be the reduction of the intracellular concentration of toxic sugars or
CC       sugar metabolites. {ECO:0000255|HAMAP-Rule:MF_00517}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00517}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00517}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. SotB (TC
CC       2.A.1.2) family. {ECO:0000255|HAMAP-Rule:MF_00517}.
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DR   EMBL; L42023; AAC21806.1; -; Genomic_DNA.
DR   PIR; E64143; E64143.
DR   RefSeq; NP_438304.1; NC_000907.1.
DR   RefSeq; WP_005694422.1; NC_000907.1.
DR   AlphaFoldDB; P44535; -.
DR   SMR; P44535; -.
DR   STRING; 71421.HI_0135; -.
DR   EnsemblBacteria; AAC21806; AAC21806; HI_0135.
DR   KEGG; hin:HI_0135; -.
DR   PATRIC; fig|71421.8.peg.137; -.
DR   eggNOG; COG2814; Bacteria.
DR   HOGENOM; CLU_001265_61_1_6; -.
DR   OMA; SAHFTAY; -.
DR   PhylomeDB; P44535; -.
DR   BioCyc; HINF71421:G1GJ1-145-MON; -.
DR   Proteomes; UP000000579; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015144; F:carbohydrate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   HAMAP; MF_00517; MFS_SotB; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR023495; Sugar_effux_transptr_put.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW   Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..396
FT                   /note="Probable sugar efflux transporter"
FT                   /id="PRO_0000209327"
FT   TRANSMEM        15..35
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT   TRANSMEM        109..129
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT   TRANSMEM        137..157
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT   TRANSMEM        168..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT   TRANSMEM        209..229
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT   TRANSMEM        245..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT   TRANSMEM        273..293
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT   TRANSMEM        297..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT   TRANSMEM        333..353
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT   TRANSMEM        365..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
SQ   SEQUENCE   396 AA;  43360 MW;  B7994F2F9E9339C8 CRC64;
     MSLYLKAEKI QSWRVLIMAC AGFIFNTTEF VPVAMLSDIA QSFDMQTADT GLMMTVYAWT
     VLIMSLPAML ATGNMERKSL LIKLFIIFIV GHILSVIAWN FWILLLARMC IALAHSVFWS
     ITASLVMRIS PKHKKTQALG MLAIGTALAT ILGLPIGRIV GQLVGWRVTF GIIAVLALSI
     MFLIIRLLPN LPSKNAGSIA SLPLLAKRPL LLWLYVTTAI VISAHFTAYT YIEPFMIDVG
     HLDPNFATAV LLVFGFSGIA ASLLFNRLYR FAPTKFIVVS MSLLMFSLLL LLFSTKTIIA
     MFSLVFIWGI GISCIGLSLQ MRVLKLAPDA TDVATAIYSG IFNAGIGAGA LFGNLATTYL
     GLNEIGYTGA ALGLIGFIIF ITTHLKYRHT FLLQNK