ID   SOTB_HELAH              Reviewed;         391 AA.
AC   Q17YP7;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   25-JUL-2006, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Probable sugar efflux transporter {ECO:0000255|HAMAP-Rule:MF_00517};
GN   Name=sotB {ECO:0000255|HAMAP-Rule:MF_00517}; OrderedLocusNames=Hac_0393;
OS   Helicobacter acinonychis (strain Sheeba).
OC   Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC   Helicobacteraceae; Helicobacter.
OX   NCBI_TaxID=382638;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Sheeba;
RX   PubMed=16789826; DOI=10.1371/journal.pgen.0020120;
RA   Eppinger M., Baar C., Linz B., Raddatz G., Lanz C., Keller H., Morelli G.,
RA   Gressmann H., Achtman M., Schuster S.C.;
RT   "Who ate whom? Adaptive Helicobacter genomic changes that accompanied a
RT   host jump from early humans to large felines.";
RL   PLoS Genet. 2:1097-1110(2006).
CC   -!- FUNCTION: Involved in the efflux of sugars. The physiological role may
CC       be the reduction of the intracellular concentration of toxic sugars or
CC       sugar metabolites. {ECO:0000255|HAMAP-Rule:MF_00517}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_00517}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_00517}.
CC   -!- SIMILARITY: Belongs to the major facilitator superfamily. SotB (TC
CC       2.A.1.2) family. {ECO:0000255|HAMAP-Rule:MF_00517}.
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DR   EMBL; AM260522; CAJ99229.1; -; Genomic_DNA.
DR   RefSeq; WP_011577343.1; NC_008229.1.
DR   AlphaFoldDB; Q17YP7; -.
DR   SMR; Q17YP7; -.
DR   STRING; 382638.Hac_0393; -.
DR   EnsemblBacteria; CAJ99229; CAJ99229; Hac_0393.
DR   KEGG; hac:Hac_0393; -.
DR   eggNOG; COG2814; Bacteria.
DR   HOGENOM; CLU_001265_61_1_7; -.
DR   OMA; GSIVIHQ; -.
DR   OrthoDB; 1384345at2; -.
DR   BioCyc; HACI382638:HAC_RS01775-MON; -.
DR   Proteomes; UP000000775; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015144; F:carbohydrate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.20.1250.20; -; 1.
DR   HAMAP; MF_00517; MFS_SotB; 1.
DR   InterPro; IPR011701; MFS.
DR   InterPro; IPR020846; MFS_dom.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR023495; Sugar_effux_transptr_put.
DR   Pfam; PF07690; MFS_1; 1.
DR   SUPFAM; SSF103473; SSF103473; 1.
DR   PROSITE; PS50850; MFS; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Membrane; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..391
FT                   /note="Probable sugar efflux transporter"
FT                   /id="PRO_1000050799"
FT   TRANSMEM        16..36
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT   TRANSMEM        82..102
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT   TRANSMEM        103..123
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT   TRANSMEM        138..158
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT   TRANSMEM        170..190
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT   TRANSMEM        210..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT   TRANSMEM        247..267
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT   TRANSMEM        277..297
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT   TRANSMEM        300..320
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT   TRANSMEM        338..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT   TRANSMEM        361..381
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
SQ   SEQUENCE   391 AA;  42881 MW;  5248F7BA7113EA8B CRC64;
     MMITKQSYKK LALMRVFVFS LSAFIFNTTE FVPIALLSDI AKSFEMESAS VGLMITLYAW
     IVSLGSLPLM LLSAKIERKR LLLFLFGLFI VSHILSVVAW DFWVLLISRM GIALAHSVFW
     SITASLVIRV APIGRKQQAL GLLALGSSLA MILGLPLGRI IGQMLDWRST FGMIGGVALL
     VALLMYRLLP SLPSRNAGTL SSLPVLMKRP LLVGIYLLVI LAISGHFTTY SYIEPFIIQI
     SQFSPEVATL MLFVFGLAGV MGSFLFGRFY EKNPKKFIAC AIILVLCPQL LLFSFKHLEW
     VIFLQIFLWG IGITSLGISL QMRVLQLAPN ATDVASAIFS GSYNVGIGSG ALFGSIVIHQ
     LGLGYIGFVG GALGLLALFW FNFITIKFGA K