SOTB_HELPJ
ID SOTB_HELPJ Reviewed; 391 AA.
AC Q9ZK31;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 25-MAY-2022, entry version 115.
DE RecName: Full=Probable sugar efflux transporter {ECO:0000255|HAMAP-Rule:MF_00517};
GN Name=sotB {ECO:0000255|HAMAP-Rule:MF_00517}; OrderedLocusNames=jhp_1111;
OS Helicobacter pylori (strain J99 / ATCC 700824) (Campylobacter pylori J99).
OC Bacteria; Proteobacteria; Epsilonproteobacteria; Campylobacterales;
OC Helicobacteraceae; Helicobacter.
OX NCBI_TaxID=85963;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=J99 / ATCC 700824;
RX PubMed=9923682; DOI=10.1038/16495;
RA Alm R.A., Ling L.-S.L., Moir D.T., King B.L., Brown E.D., Doig P.C.,
RA Smith D.R., Noonan B., Guild B.C., deJonge B.L., Carmel G., Tummino P.J.,
RA Caruso A., Uria-Nickelsen M., Mills D.M., Ives C., Gibson R., Merberg D.,
RA Mills S.D., Jiang Q., Taylor D.E., Vovis G.F., Trust T.J.;
RT "Genomic sequence comparison of two unrelated isolates of the human gastric
RT pathogen Helicobacter pylori.";
RL Nature 397:176-180(1999).
CC -!- FUNCTION: Involved in the efflux of sugars. The physiological role may
CC be the reduction of the intracellular concentration of toxic sugars or
CC sugar metabolites. {ECO:0000255|HAMAP-Rule:MF_00517}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00517}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00517}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. SotB (TC
CC 2.A.1.2) family. {ECO:0000255|HAMAP-Rule:MF_00517}.
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DR EMBL; AE001439; AAD06692.1; -; Genomic_DNA.
DR PIR; H71846; H71846.
DR RefSeq; WP_000973621.1; NZ_CP011330.1.
DR AlphaFoldDB; Q9ZK31; -.
DR SMR; Q9ZK31; -.
DR STRING; 85963.jhp_1111; -.
DR EnsemblBacteria; AAD06692; AAD06692; jhp_1111.
DR KEGG; hpj:jhp_1111; -.
DR PATRIC; fig|85963.30.peg.1468; -.
DR eggNOG; COG2814; Bacteria.
DR OMA; GSIVIHQ; -.
DR Proteomes; UP000000804; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015144; F:carbohydrate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1250.20; -; 1.
DR HAMAP; MF_00517; MFS_SotB; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR023495; Sugar_effux_transptr_put.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Sugar transport;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..391
FT /note="Probable sugar efflux transporter"
FT /id="PRO_0000209329"
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TRANSMEM 82..102
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TRANSMEM 138..158
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TRANSMEM 170..190
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TRANSMEM 210..230
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TRANSMEM 247..267
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TRANSMEM 300..320
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TRANSMEM 338..358
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TRANSMEM 361..381
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
SQ SEQUENCE 391 AA; 43312 MW; A224FB5E52F110B7 CRC64;
MMITKQSYQR FALMRVFVFS LSAFIFNTTE FVPVALLSDI AKSFEMESAT VGLMITAYAW
VVSLGSLPLM LLSAKIERKR LLLFLFALFI FSHILSALAW NFWVLLLSRM GIAFAHSIFW
SITASLVIRV APRNKKQQAL GLLALGSSLA MILGLPLGRI IGQILDWRST FGVIGGVATL
IMLLMWKLLP HLPSRNAGTL ASVPILMKRP LLVGIYLLVI MVISGHFTTY SYIEPFIIQI
SQFSPDITTL MLFVFGLAGV VGSFLFGRLY AKNSRKFIAF AMVLVICPQL LLFVFKNLEW
VIFLQIFLWG IGITSLTIAL QMRVLQLAPD ATDVASAIFS GSYNVGIGSG ALFGSIVIHQ
LGLEYIGFVG GALGLLALFW LRFITIKFKK T