SOTB_KLEP7
ID SOTB_KLEP7 Reviewed; 399 AA.
AC A6T8Y8;
DT 15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT 21-AUG-2007, sequence version 1.
DT 25-MAY-2022, entry version 73.
DE RecName: Full=Probable sugar efflux transporter {ECO:0000255|HAMAP-Rule:MF_00517};
GN Name=sotB {ECO:0000255|HAMAP-Rule:MF_00517};
GN OrderedLocusNames=KPN78578_15980; ORFNames=KPN_01628;
OS Klebsiella pneumoniae subsp. pneumoniae (strain ATCC 700721 / MGH 78578).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=272620;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 700721 / MGH 78578;
RG The Klebsiella pneumonia Genome Sequencing Project;
RA McClelland M., Sanderson E.K., Spieth J., Clifton W.S., Latreille P.,
RA Sabo A., Pepin K., Bhonagiri V., Porwollik S., Ali J., Wilson R.K.;
RL Submitted (SEP-2006) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the efflux of sugars. The physiological role may
CC be the reduction of the intracellular concentration of toxic sugars or
CC sugar metabolites. {ECO:0000255|HAMAP-Rule:MF_00517}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00517}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00517}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. SotB (TC
CC 2.A.1.2) family. {ECO:0000255|HAMAP-Rule:MF_00517}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; CP000647; ABR77059.1; -; Genomic_DNA.
DR RefSeq; WP_002904407.1; NC_009648.1.
DR AlphaFoldDB; A6T8Y8; -.
DR SMR; A6T8Y8; -.
DR STRING; 272620.KPN_01628; -.
DR EnsemblBacteria; ABR77059; ABR77059; KPN_01628.
DR KEGG; kpn:KPN_01628; -.
DR HOGENOM; CLU_001265_61_1_6; -.
DR OMA; SAHFTAY; -.
DR Proteomes; UP000000265; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015144; F:carbohydrate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1250.20; -; 1.
DR HAMAP; MF_00517; MFS_SotB; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR023495; Sugar_effux_transptr_put.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..399
FT /note="Probable sugar efflux transporter"
FT /id="PRO_1000050800"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TRANSMEM 168..188
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TRANSMEM 273..293
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
SQ SEQUENCE 399 AA; 42609 MW; 0E5073D38B11A3D5 CRC64;
MTTNTVSRKV AWLRVVTLAI AAFIFNTTEF APVGLLSDIA DSFGMETAQV GMMLTIYAWV
VALMSLPFML LTSKVERRRL LIGLFILFIA SHVLSFFAWN FDVLVISRIG IAFAHAVFWS
ITSALAIRMA PPGKRAQALS LIATGTALAM VFGIPIGRII GQYFGWRMTF LAIGLGALAT
LACLVKLLPT LPSEHSGSLK SLPVLFRRPA LVSVYILTVV VVTAHYTAYS YIEPFVQTVA
GLSGNFATVL LLILGGAGII GSILFGKLGN QHASGLISLA IALLLACLLL LLPASHNPQH
LMLLSIFWGV AIMIIGLGMQ VKVLASAPDA TDVAMSLFSG IFNIGIGAGA LVGSQVSLHL
SMASVGYVGA IPALVALVWS LMIFRRWPVS LEDHQPHHS