SOTB_SALTY
ID SOTB_SALTY Reviewed; 396 AA.
AC P58531;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2002, sequence version 1.
DT 03-AUG-2022, entry version 108.
DE RecName: Full=Probable sugar efflux transporter {ECO:0000255|HAMAP-Rule:MF_00517};
GN Name=sotB {ECO:0000255|HAMAP-Rule:MF_00517}; Synonyms=pnuP;
GN OrderedLocusNames=STM1522;
OS Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720).
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Salmonella.
OX NCBI_TaxID=99287;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT PNUP*144.
RA Jeong H., Zhu N., Roth J.R.;
RT "Alteration of PnuD, a putative nucleoside transporter, or YdeA opens a
RT route of nicotinamide mononucleotide assimilation in Salmonella enterica
RT serovar Typhimurium.";
RL Submitted (OCT-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=LT2 / SGSC1412 / ATCC 700720;
RX PubMed=11677609; DOI=10.1038/35101614;
RA McClelland M., Sanderson K.E., Spieth J., Clifton S.W., Latreille P.,
RA Courtney L., Porwollik S., Ali J., Dante M., Du F., Hou S., Layman D.,
RA Leonard S., Nguyen C., Scott K., Holmes A., Grewal N., Mulvaney E.,
RA Ryan E., Sun H., Florea L., Miller W., Stoneking T., Nhan M., Waterston R.,
RA Wilson R.K.;
RT "Complete genome sequence of Salmonella enterica serovar Typhimurium LT2.";
RL Nature 413:852-856(2001).
CC -!- FUNCTION: Involved in the efflux of sugars. The physiological role may
CC be the reduction of the intracellular concentration of toxic sugars or
CC sugar metabolites. {ECO:0000255|HAMAP-Rule:MF_00517}.
CC -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC Rule:MF_00517}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC Rule:MF_00517}.
CC -!- SIMILARITY: Belongs to the major facilitator superfamily. SotB (TC
CC 2.A.1.2) family. {ECO:0000255|HAMAP-Rule:MF_00517}.
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DR EMBL; AF440748; AAL33645.1; -; Genomic_DNA.
DR EMBL; AE006468; AAL20441.1; -; Genomic_DNA.
DR RefSeq; NP_460482.1; NC_003197.2.
DR RefSeq; WP_000154625.1; NC_003197.2.
DR AlphaFoldDB; P58531; -.
DR SMR; P58531; -.
DR STRING; 99287.STM1522; -.
DR PaxDb; P58531; -.
DR EnsemblBacteria; AAL20441; AAL20441; STM1522.
DR GeneID; 1253040; -.
DR KEGG; stm:STM1522; -.
DR PATRIC; fig|99287.12.peg.1610; -.
DR HOGENOM; CLU_001265_61_1_6; -.
DR OMA; SAHFTAY; -.
DR PhylomeDB; P58531; -.
DR BioCyc; SENT99287:STM1522-MON; -.
DR Proteomes; UP000001014; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015144; F:carbohydrate transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR Gene3D; 1.20.1250.20; -; 1.
DR HAMAP; MF_00517; MFS_SotB; 1.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR InterPro; IPR023495; Sugar_effux_transptr_put.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; SSF103473; 1.
DR PROSITE; PS50850; MFS; 1.
PE 3: Inferred from homology;
KW Cell inner membrane; Cell membrane; Membrane; Reference proteome;
KW Sugar transport; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..396
FT /note="Probable sugar efflux transporter"
FT /id="PRO_0000209335"
FT TOPO_DOM 1..14
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 15..35
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TOPO_DOM 36..49
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TOPO_DOM 71..80
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 81..101
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TOPO_DOM 102
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TOPO_DOM 124..135
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TOPO_DOM 157..168
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 169..189
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TOPO_DOM 190..208
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 209..229
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TOPO_DOM 230..245
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 246..266
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TOPO_DOM 267..274
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TOPO_DOM 296..300
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 301..321
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TOPO_DOM 322..332
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 333..353
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TOPO_DOM 354..363
FT /note="Periplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 364..384
FT /note="Helical"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00517"
FT TOPO_DOM 385..396
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT VARIANT 151
FT /note="V -> G (in pnuP*144)"
SQ SEQUENCE 396 AA; 42481 MW; 4F2F3D4A69EC7050 CRC64;
MTINPVSRKV AWLRVVTLAI AAFIFNTTEF VPVGLLSDIA ESFHMQTAQV GIMLTIYAWV
VAVMSLPFML LTSQMERRKL LIYLFVLFIA SHVLSFLAWN FTVLVISRIG IAFAHAIFWS
ITASLAIRLA PAGKRAQALS LIATGTALAM VLGLPIGRVV GQYFGWRTTF FAIGMGALIT
LLCLIKLLPK LPSEHSGSLK SLPLLFRRPA LMSLYVLTVV VVTAHYTAYS YIEPFVQNVA
GLSANFATVL LLILGGAGII GSLVFGKLGN RHASSLVSIA IALLVVCLLL LLPAAESEAH
LAILSIFWGI AIMVIGLGMQ VKVLALAPDA TDVAMALFSG IFNIGIGAGA LVGNQVSLHW
SMSAIGYIGA IPACAALVWA VLIFRKWPVT LEEQPH
