SOTI_DROME
ID SOTI_DROME Reviewed; 147 AA.
AC Q9VFK3;
DT 07-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Male-specific protein scotti {ECO:0000303|PubMed:18434411};
GN Name=soti {ECO:0000303|PubMed:18434411}; ORFNames=CG8489;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:AAF55052.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAF55052.1}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AAL28298.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAL28298.1};
RA Stapleton M., Brokstein P., Hong L., Agbayani A., Carlson J.W., Champe M.,
RA Chavez C., Dorsett V., Dresnek D., Farfan D., Frise E., George R.A.,
RA Gonzalez M., Guarin H., Kronmiller B., Li P.W., Liao G., Miranda A.,
RA Mungall C.J., Nunoo J., Pacleb J.M., Paragas V., Park S., Patel S.,
RA Phouanenavong S., Wan K.H., Yu C., Lewis S.E., Rubin G.M., Celniker S.E.;
RL Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=18434411; DOI=10.1242/dev.021949;
RA Barreau C., Benson E., Gudmannsdottir E., Newton F., White-Cooper H.;
RT "Post-meiotic transcription in Drosophila testes.";
RL Development 135:1897-1902(2008).
CC -!- FUNCTION: Post-meiotically transcribed gene that has a role in late
CC spermiogenesis; required for actin cone progression during spermatid
CC individualization. {ECO:0000269|PubMed:18434411}.
CC -!- TISSUE SPECIFICITY: Expressed in primary spermatocytes and round
CC spermatids. Low expression is seen in very short elongating cysts, but
CC were detected at high levels in a few longer spermatid cysts.
CC {ECO:0000269|PubMed:18434411}.
CC -!- DISRUPTION PHENOTYPE: Male sterile showing spermatid individualization
CC defects. No gross defects seen in testis organization or spermatid
CC elongation but the seminal vesicles are empty.
CC {ECO:0000269|PubMed:18434411}.
CC -!- SIMILARITY: Belongs to the male-specific scotti family. {ECO:0000305}.
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DR EMBL; AE014297; AAF55052.1; -; Genomic_DNA.
DR EMBL; AY060750; AAL28298.1; -; mRNA.
DR RefSeq; NP_650358.1; NM_142101.3.
DR AlphaFoldDB; Q9VFK3; -.
DR BioGRID; 66824; 4.
DR STRING; 7227.FBpp0082399; -.
DR GlyGen; Q9VFK3; 1 site.
DR PaxDb; Q9VFK3; -.
DR DNASU; 41748; -.
DR EnsemblMetazoa; FBtr0082940; FBpp0082399; FBgn0038225.
DR GeneID; 41748; -.
DR KEGG; dme:Dmel_CG8489; -.
DR UCSC; CG8489-RA; d. melanogaster.
DR CTD; 41748; -.
DR FlyBase; FBgn0038225; soti.
DR VEuPathDB; VectorBase:FBgn0038225; -.
DR HOGENOM; CLU_120156_0_0_1; -.
DR InParanoid; Q9VFK3; -.
DR OMA; LPQRWGQ; -.
DR OrthoDB; 1518215at2759; -.
DR PhylomeDB; Q9VFK3; -.
DR BioGRID-ORCS; 41748; 0 hits in 1 CRISPR screen.
DR GenomeRNAi; 41748; -.
DR PRO; PR:Q9VFK3; -.
DR Proteomes; UP000000803; Chromosome 3R.
DR Bgee; FBgn0038225; Expressed in testis and 11 other tissues.
DR ExpressionAtlas; Q9VFK3; baseline and differential.
DR Genevisible; Q9VFK3; DM.
DR GO; GO:0007291; P:sperm individualization; IMP:UniProtKB.
DR InterPro; IPR031397; Soti.
DR Pfam; PF17079; SOTI; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; Differentiation; Glycoprotein; Reference proteome;
KW Spermatogenesis.
FT CHAIN 1..147
FT /note="Male-specific protein scotti"
FT /id="PRO_0000379443"
FT REGION 55..93
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 128
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 147 AA; 16714 MW; 7D9FCCE6964F471D CRC64;
MDVLHGHDLY DEQLIDRVGD AVNEDAGDDL DTLEDGQQQQ RLGVNRQMDI LLDAPQEPPL
GVFPAQGGPN GPPRRRKKRS FYTMTKPTPP CQSQEPEMCL LMASVTRAMR HVREDQRGEY
FANYLVENMT SQNYPNGMGL PQHWGQF
