SOX10_CHICK
ID SOX10_CHICK Reviewed; 461 AA.
AC Q9W757;
DT 01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 2.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Transcription factor SOX-10;
DE Short=cSOX10;
GN Name=SOX10;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Cheng Y.-C., Cheung M., Abu-Elmagd M., Orme T.A., Scotting P.J.;
RT "Cloning and expression pattern of chick cSox10.";
RL Submitted (JAN-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=10624949; DOI=10.1016/s0896-6273(00)81033-8;
RA Schneider C., Wicht H., Enderich J., Wegner M., Rohrer H.;
RT "Bone morphogenetic proteins are required in vivo for the generation of
RT sympathetic neurons.";
RL Neuron 24:861-870(1999).
CC -!- FUNCTION: Transcription factor that plays a central role in developing
CC and mature glia. Specifically activates expression of myelin genes,
CC during oligodendrocyte (OL) maturation, thereby playing a central role
CC in oligodendrocyte maturation and CNS myelination.
CC {ECO:0000250|UniProtKB:Q04888}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P56693}. Nucleus
CC {ECO:0000250|UniProtKB:P56693}.
CC -!- DOMAIN: The transactivation domains TAM and TAC (for transactivation
CC domain in the middle and at the C-terminus, respectively) are required
CC to contact transcriptional coactivators and basal transcriptional
CC machinery components and thereby induce gene transactivation.
CC {ECO:0000250|UniProtKB:P48436}.
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DR EMBL; AF152356; AAD38050.2; -; mRNA.
DR EMBL; AJ245601; CAB65026.1; -; mRNA.
DR RefSeq; NP_990123.1; NM_204792.1.
DR AlphaFoldDB; Q9W757; -.
DR SMR; Q9W757; -.
DR STRING; 9031.ENSGALP00000020056; -.
DR PaxDb; Q9W757; -.
DR Ensembl; ENSGALT00000020083; ENSGALP00000020056; ENSGALG00000012290.
DR GeneID; 395573; -.
DR KEGG; gga:395573; -.
DR CTD; 6663; -.
DR VEuPathDB; HostDB:geneid_395573; -.
DR eggNOG; KOG0527; Eukaryota.
DR GeneTree; ENSGT00940000158046; -.
DR HOGENOM; CLU_031800_0_0_1; -.
DR InParanoid; Q9W757; -.
DR OMA; PPHYAEQ; -.
DR OrthoDB; 782373at2759; -.
DR PhylomeDB; Q9W757; -.
DR PRO; PR:Q9W757; -.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000012290; Expressed in cerebellum and 3 other tissues.
DR ExpressionAtlas; Q9W757; baseline and differential.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0060959; P:cardiac neuron development; IEP:UniProtKB.
DR GO; GO:0022010; P:central nervous system myelination; ISS:UniProtKB.
DR GO; GO:0048484; P:enteric nervous system development; IBA:GO_Central.
DR GO; GO:0002009; P:morphogenesis of an epithelium; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0001755; P:neural crest cell migration; IBA:GO_Central.
DR GO; GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.
DR GO; GO:0048709; P:oligodendrocyte differentiation; ISS:UniProtKB.
DR GO; GO:0007422; P:peripheral nervous system development; IBA:GO_Central.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR022151; Sox_N.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12444; Sox_N; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..461
FT /note="Transcription factor SOX-10"
FT /id="PRO_0000048749"
FT DNA_BIND 98..166
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 1..60
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 56..96
FT /note="Dimerization (DIM)"
FT /evidence="ECO:0000250|UniProtKB:P56693"
FT REGION 154..191
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..268
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..306
FT /note="Transactivation domain (TAM)"
FT /evidence="ECO:0000250|UniProtKB:P56693"
FT REGION 350..461
FT /note="Transactivation domain (TAC)"
FT /evidence="ECO:0000250|UniProtKB:P56693"
FT REGION 350..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..461
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 154..178
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 244..259
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 437..461
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 461 AA; 49858 MW; 20F12F3AB1621F57 CRC64;
MADDQDLSEV EMSPVGSEDH HCLSPGPSMA SDNSSHLASS GNGEMGKVKK EQQDSEADDD
KFPVCIREAV SQVLSGYDWT LVPMPVRVNG SNKSKPHVKR PMNAFMVWAQ AARRKLADQY
PHLHNAELSK TLGKLWRLLN ESDKRPFIEE AERLRMQHKK DHPDYKYQPR RRKNGKATQG
EGEGQVEGEA GGAASIQAHY KNAHLDHRHP GEGSPMSDGH PEHSSGQSHG PPTPPTTPKT
ELQAGKADSK REGRSLGEGG KPHIDFGNVD IGEISHEVMS NMETFDVNEF DQYLPPNGHA
GHPGHVGGYA AAAGYGLGSA LAAASGHSAW ISKQHGVSLS ATTSPVVDSK AQVKTEGSAP
GGHYTDQPST SQIAYTSLSL PHYGSAFPSI SRPQFDYPDH QPSGPYYSHS SQASGLYSAF
SYMGPSQRPL YTAISDPAPS VPQSHSPTHW EQPVYTTLSR P
