SOX10_RAT
ID SOX10_RAT Reviewed; 466 AA.
AC O55170;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Transcription factor SOX-10;
GN Name=Sox10;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley;
RX PubMed=9412504; DOI=10.1523/jneurosci.18-01-00237.1998;
RA Kuhlbrodt K., Herbarth B., Sock E., Hermans-Borgmeyer I., Wegner M.;
RT "Sox10, a novel transcriptional modulator in glial cells.";
RL J. Neurosci. 18:237-250(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP FUNCTION.
RX PubMed=26525805; DOI=10.1111/jnc.13414;
RA Baroti T., Schillinger A., Wegner M., Stolt C.C.;
RT "Sox13 functionally complements the related Sox5 and Sox6 as important
RT developmental modulators in mouse spinal cord oligodendrocytes.";
RL J. Neurochem. 136:316-328(2016).
CC -!- FUNCTION: Transcription factor that plays a central role in developing
CC and mature glia (By similarity). Specifically activates expression of
CC myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15
CC and MYRF, thereby playing a central role in oligodendrocyte maturation
CC and CNS myelination (By similarity). Once induced, MYRF cooperates with
CC SOX10 to implement the myelination program (By similarity).
CC Transcriptional activator of MITF, acting synergistically with PAX3 (By
CC similarity). Transcriptional activator of MBP, via binding to the gene
CC promoter (PubMed:26525805). {ECO:0000250|UniProtKB:P56693,
CC ECO:0000250|UniProtKB:Q04888, ECO:0000269|PubMed:26525805}.
CC -!- SUBUNIT: Monomer. Interacts with Armcx3 at the mitochondrial outer
CC membrane surface. Interacts with PAX3 (By similarity).
CC {ECO:0000250|UniProtKB:P56693, ECO:0000250|UniProtKB:Q04888}.
CC -!- INTERACTION:
CC O55170; Q13287: NMI; Xeno; NbExp=4; IntAct=EBI-1185693, EBI-372942;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q04888}. Nucleus
CC {ECO:0000269|PubMed:9412504}. Mitochondrion outer membrane
CC {ECO:0000250|UniProtKB:Q04888}; Peripheral membrane protein
CC {ECO:0000250|UniProtKB:Q04888}; Cytoplasmic side
CC {ECO:0000250|UniProtKB:Q04888}.
CC -!- TISSUE SPECIFICITY: Predominant expression in glial cells of the
CC nervous system. {ECO:0000269|PubMed:9412504}.
CC -!- DOMAIN: The transactivation domains TAM and TAC (for transactivation
CC domain in the middle and at the C-terminus, respectively) are required
CC to contact transcriptional coactivators and basal transcriptional
CC machinery components and thereby induce gene transactivation.
CC {ECO:0000250|UniProtKB:P48436}.
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DR EMBL; AJ001029; CAA04485.1; -; mRNA.
DR EMBL; BC062067; AAH62067.1; -; mRNA.
DR RefSeq; NP_062066.1; NM_019193.2.
DR RefSeq; XP_017450187.1; XM_017594698.1.
DR AlphaFoldDB; O55170; -.
DR SMR; O55170; -.
DR BioGRID; 248015; 17.
DR IntAct; O55170; 2.
DR MINT; O55170; -.
DR STRING; 10116.ENSRNOP00000015283; -.
DR iPTMnet; O55170; -.
DR PhosphoSitePlus; O55170; -.
DR PaxDb; O55170; -.
DR Ensembl; ENSRNOT00000015283; ENSRNOP00000015283; ENSRNOG00000011305.
DR GeneID; 29361; -.
DR KEGG; rno:29361; -.
DR UCSC; RGD:3735; rat.
DR CTD; 6663; -.
DR RGD; 3735; Sox10.
DR eggNOG; KOG0527; Eukaryota.
DR GeneTree; ENSGT00940000158046; -.
DR HOGENOM; CLU_031800_0_0_1; -.
DR InParanoid; O55170; -.
DR OMA; PPHYADQ; -.
DR OrthoDB; 782373at2759; -.
DR PhylomeDB; O55170; -.
DR PRO; PR:O55170; -.
DR Proteomes; UP000002494; Chromosome 7.
DR Bgee; ENSRNOG00000011305; Expressed in cerebellum and 11 other tissues.
DR Genevisible; O55170; RN.
DR GO; GO:0005737; C:cytoplasm; IDA:RGD.
DR GO; GO:0031315; C:extrinsic component of mitochondrial outer membrane; ISO:RGD.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; IDA:RGD.
DR GO; GO:0003682; F:chromatin binding; IDA:RGD.
DR GO; GO:0003677; F:DNA binding; IDA:RGD.
DR GO; GO:0001216; F:DNA-binding transcription activator activity; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0140297; F:DNA-binding transcription factor binding; IPI:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; ISO:RGD.
DR GO; GO:1990841; F:promoter-specific chromatin binding; IMP:RGD.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:RGD.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:UniProtKB.
DR GO; GO:0048468; P:cell development; NAS:RGD.
DR GO; GO:0030154; P:cell differentiation; ISO:RGD.
DR GO; GO:0048469; P:cell maturation; ISO:RGD.
DR GO; GO:0071393; P:cellular response to progesterone stimulus; IEP:RGD.
DR GO; GO:0071466; P:cellular response to xenobiotic stimulus; IEP:RGD.
DR GO; GO:0022010; P:central nervous system myelination; ISS:UniProtKB.
DR GO; GO:0048589; P:developmental growth; ISO:RGD.
DR GO; GO:0048546; P:digestive tract morphogenesis; ISO:RGD.
DR GO; GO:0048484; P:enteric nervous system development; ISO:RGD.
DR GO; GO:0001701; P:in utero embryonic development; ISO:RGD.
DR GO; GO:0032808; P:lacrimal gland development; ISO:RGD.
DR GO; GO:0030318; P:melanocyte differentiation; ISO:RGD.
DR GO; GO:0061138; P:morphogenesis of a branching epithelium; ISO:RGD.
DR GO; GO:0002009; P:morphogenesis of an epithelium; IBA:GO_Central.
DR GO; GO:0043066; P:negative regulation of apoptotic process; ISO:RGD.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISO:RGD.
DR GO; GO:0010626; P:negative regulation of Schwann cell proliferation; IMP:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0001755; P:neural crest cell migration; ISO:RGD.
DR GO; GO:0007405; P:neuroblast proliferation; IEA:Ensembl.
DR GO; GO:0014003; P:oligodendrocyte development; ISS:UniProtKB.
DR GO; GO:0048709; P:oligodendrocyte differentiation; ISS:UniProtKB.
DR GO; GO:0007422; P:peripheral nervous system development; ISO:RGD.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:RGD.
DR GO; GO:0014015; P:positive regulation of gliogenesis; ISO:RGD.
DR GO; GO:0031643; P:positive regulation of myelination; IMP:RGD.
DR GO; GO:0002052; P:positive regulation of neuroblast proliferation; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:RGD.
DR GO; GO:0048863; P:stem cell differentiation; IEP:RGD.
DR GO; GO:0006368; P:transcription elongation from RNA polymerase II promoter; IDA:RGD.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR022151; Sox_N.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12444; Sox_N; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 1: Evidence at protein level;
KW Activator; Cytoplasm; DNA-binding; Membrane; Mitochondrion;
KW Mitochondrion outer membrane; Nucleus; Phosphoprotein; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..466
FT /note="Transcription factor SOX-10"
FT /id="PRO_0000048748"
FT DNA_BIND 104..172
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 62..102
FT /note="Dimerization (DIM)"
FT /evidence="ECO:0000250|UniProtKB:P56693"
FT REGION 160..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 213..275
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..310
FT /note="Transactivation domain (TAM)"
FT /evidence="ECO:0000250|UniProtKB:P56693"
FT REGION 353..466
FT /note="Transactivation domain (TAC)"
FT /evidence="ECO:0000250|UniProtKB:P56693"
FT REGION 355..375
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 433..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..67
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 160..184
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..266
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 357..375
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 436..466
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 24
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:P56693"
SQ SEQUENCE 466 AA; 50039 MW; 094B0C5E42D83454 CRC64;
MAEEQDLSEV ELSPVGSEEP RCLSPSSAPS LGPDGGGGGS GLRASPGPGE LGKVKKEQQD
GEADDDKFPV CIREAVSQVL SGYDWTLVPM PVRVNGASKS KPHVKRPMNA FMVWAQAARR
KLADQYPHLH NAELSKTLGK LWRLLNESDK RPFIEEAERL RMQHKKDHPD YKYQPRRRKN
GKAAQGEAEC PGGETDQGGA AAIQAHYKSA HLDHRHPEEG SPMSDGNPEH PSGQSHGPPT
PPTTPKTELQ SGKADPKRDG RSLGEGGKPH IDFGNVDIGE ISHEVMSNME TFDVTELDQY
LPPNGHPGHV GSYSAAGYGL SSALAVASGH SAWISKPPGV ALPTVSPPAV DAKAQVKTET
TGPQGPPHYT DQPSTSQIAY TSLSLPHYGS AFPSISRPQF DYSDHQPSGP YYGHAGQASG
LYSAFSYMGP SQRPLYTAIS DPSPSGPQSH SPTHWEQPVY TTLSRP
