ID   SOX11_CHICK             Reviewed;         396 AA.
AC   P48435;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Transcription factor SOX-11;
DE            Short=cSox11;
GN   Name=SOX11;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Embryo;
RX   PubMed=7748786; DOI=10.1016/0925-4773(94)00299-3;
RA   Uwanogho D., Rex M., Cartwright E.J., Pearl G., Healy C., Scotting P.J.,
RA   Sharpe P.T.;
RT   "Embryonic expression of the chicken Sox2, Sox3 and Sox11 genes suggests an
RT   interactive role in neuronal development.";
RL   Mech. Dev. 49:23-36(1995).
CC   -!- FUNCTION: Transcription factor that acts as a transcriptional activator
CC       (By similarity). May function as a switch in neuronal development
CC       (PubMed:7748786). {ECO:0000250|UniProtKB:Q7M6Y2,
CC       ECO:0000269|PubMed:7748786}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC   -!- TISSUE SPECIFICITY: Low level expression is seen in undifferentiated
CC       proliferating cells of the neural epithelium. Greater expression is
CC       seen in the maturing neurons after they leave the neural epithelium.
CC       Also expressed in the embryonic gut epithelium and adrenal medulla.
CC       {ECO:0000269|PubMed:7748786}.
CC   -!- DEVELOPMENTAL STAGE: Expression is maximal at stages 24-31, then begins
CC       to decline. Expression is low by stage 37 and disappears by stage 39.
CC       Does not appear to be expressed in adults.
CC       {ECO:0000269|PubMed:7748786}.
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DR   EMBL; U12534; AAB09664.1; -; mRNA.
DR   PIR; I50707; I50707.
DR   RefSeq; NP_990518.1; NM_205187.1.
DR   AlphaFoldDB; P48435; -.
DR   SMR; P48435; -.
DR   GeneID; 396104; -.
DR   KEGG; gga:396104; -.
DR   CTD; 6664; -.
DR   VEuPathDB; HostDB:geneid_396104; -.
DR   eggNOG; KOG0527; Eukaryota.
DR   InParanoid; P48435; -.
DR   OrthoDB; 1186233at2759; -.
DR   PhylomeDB; P48435; -.
DR   PRO; PR:P48435; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR   GO; GO:0090263; P:positive regulation of canonical Wnt signaling pathway; IDA:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR029551; SOX-11.
DR   InterPro; IPR017386; SOX-12/11/4.
DR   PANTHER; PTHR10270:SF113; PTHR10270:SF113; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   PIRSF; PIRSF038098; SOX-12/11/4a; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; Differentiation; DNA-binding;
KW   Neurogenesis; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..396
FT                   /note="Transcription factor SOX-11"
FT                   /id="PRO_0000048752"
FT   DNA_BIND        49..117
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          1..22
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          116..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          203..261
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        134..153
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        246..260
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   396 AA;  43504 MW;  8E4B0A457F8BA833 CRC64;
     MVQQAESAES ESNLPREAMD TEEGEFMACS PVALDESDPD WCKTASGHIK RPMNAFMVWS
     KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR EAERLRLKHM ADYPDYKYRP
     RKKPKMDPSA KPNAGQSPEK NAPGGGSKSA KSSGKKCSKL KAAAASPPKP GAKAAPHGDY
     AGDEYVFGAL KVSSKAVKCV FVDEEEEDEE DEDELQLRIK QEADDEEEDE EPGPQQLRRY
     NVAKVPASPT LSSSAESTEG ASLYEEVRGA AGGGRLYYSF KNITKQGPPP PQPPAGLSPA
     SVPLHLHLVG RQRGGGRPPV RPQPQLLAAW PRRRRAGGGA AAGNLSLSLV DKDLDSFSEG
     SLGSHFEFPD YCTPELSEMI AGDWLEANFS DLVFTY