SOX11_MOUSE
ID SOX11_MOUSE Reviewed; 395 AA.
AC Q7M6Y2; O35178; O89036; Q04889; Q80XF0;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-DEC-2003, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Transcription factor SOX-11;
GN Name=Sox11; Synonyms=Sox-11;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND DEVELOPMENTAL STAGE.
RC TISSUE=Embryo;
RX PubMed=9337129;
RX DOI=10.1002/(sici)1097-0177(199710)210:2<79::aid-aja1>3.0.co;2-6;
RA Hargrave M., Wright E., Kun J., Emery J., Cooper L., Koopman P.;
RT "Expression of the Sox11 gene in mouse embryos suggests roles in neuronal
RT maturation and epithelio-mesenchymal induction.";
RL Dev. Dyn. 210:79-86(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND SUBCELLULAR LOCATION.
RC STRAIN=129/Ola;
RX PubMed=15456859; DOI=10.1128/mcb.24.20.8834-8846.2004;
RA Tanaka S., Kamachi Y., Tanouchi A., Hamada H., Jing N., Kondoh H.;
RT "Interplay of SOX and POU factors in regulation of the nestin gene in
RT neural primordial cells.";
RL Mol. Cell. Biol. 24:8834-8846(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE.
RX PubMed=12923295; DOI=10.1073/pnas.1734197100;
RA Aubert J., Stavridis M.P., Tweedie S., O'Reilly M., Vierlinger K., Li M.,
RA Ghazal P., Pratt T., Mason J.O., Roy D., Smith A.;
RT "Screening for mammalian neural genes via fluorescence-activated cell
RT sorter purification of neural precursors from Sox1-gfp knock-in mice.";
RL Proc. Natl. Acad. Sci. U.S.A. 100:11836-11841(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Heart, and Lung;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 57-112.
RX PubMed=8441686; DOI=10.1093/nar/21.3.744;
RA Wright E.M., Snopek B., Koopman P.;
RT "Seven new members of the Sox gene family expressed during mouse
RT development.";
RL Nucleic Acids Res. 21:744-744(1993).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic brain;
RX PubMed=15345747; DOI=10.1074/mcp.m400085-mcp200;
RA Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
RT "Phosphoproteomic analysis of the developing mouse brain.";
RL Mol. Cell. Proteomics 3:1093-1101(2004).
RN [8]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=18505825; DOI=10.1128/mcb.00338-08;
RA Hoser M., Potzner M.R., Koch J.M., Boesl M.R., Wegner M., Sock E.;
RT "Sox12 deletion in the mouse reveals nonreciprocal redundancy with the
RT related Sox4 and Sox11 transcription factors.";
RL Mol. Cell. Biol. 28:4675-4687(2008).
RN [9]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=18403418; DOI=10.1093/nar/gkn162;
RA Dy P., Penzo-Mendez A., Wang H., Pedraza C.E., Macklin W.B., Lefebvre V.;
RT "The three SoxC proteins--Sox4, Sox11 and Sox12--exhibit overlapping
RT expression patterns and molecular properties.";
RL Nucleic Acids Res. 36:3101-3117(2008).
RN [10]
RP FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=20596238; DOI=10.1038/ncomms1008;
RA Bhattaram P., Penzo-Mendez A., Sock E., Colmenares C., Kaneko K.J.,
RA Vassilev A., Depamphilis M.L., Wegner M., Lefebvre V.;
RT "Organogenesis relies on SoxC transcription factors for the survival of
RT neural and mesenchymal progenitors.";
RL Nat. Commun. 1:9-9(2010).
CC -!- FUNCTION: Transcription factor that acts as a transcriptional activator
CC (PubMed:18505825, PubMed:18403418). Binds cooperatively with
CC POU3F2/BRN2 or POU3F1/OCT6 to gene promoters, which enhances
CC transcriptional activation (PubMed:18505825, PubMed:18403418). Acts as
CC a transcriptional activator of TEAD2 by binding to its gene promoter
CC and first intron (PubMed:20596238). Plays a redundant role with SOX4
CC and SOX12 in cell survival of developing tissues such as the neural
CC tube, branchial arches and somites, thereby contributing to
CC organogenesis (PubMed:20596238). {ECO:0000269|PubMed:18403418,
CC ECO:0000269|PubMed:18505825, ECO:0000269|PubMed:20596238}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267,
CC ECO:0000269|PubMed:15456859}.
CC -!- TISSUE SPECIFICITY: Expression prominent in the periventricular cells
CC of the central nervous system, also observed in a wide range of tissues
CC involved in epithelial-mesenchymal interactions.
CC -!- DEVELOPMENTAL STAGE: Expression detected from 8.5 dpc through to 13.5
CC dpc, with a considerable increase in expression apparent at 13.5 dpc
CC (PubMed:9337129, PubMed:18505825, PubMed:20596238). Expressed
CC throughout the central and peripheral nervous system, as well as the
CC mesenchyme of many developing organs between 12.5 dpc and 14.5 dpc
CC (PubMed:18403418). Abundantly expressed in the developing cerebral
CC cortex, thalamus, hippocampus, cerebellar cortex, and ganglia in the
CC brain at 14.5 dpc and 16.5 dpc with low expression at 18.5 dpc
CC (PubMed:18505825). Abundantly expressed in the gut epithelium at 14.5
CC dpc (PubMed:18505825). Abundantly expressed in the olfactory epithelium
CC with low expression in skin, spinal cord, kidney, heart, muscle,
CC cartilage from 14.5 dpc to 18.5 dpc (PubMed:18505825). Very low
CC expression in intestine and lung, with no expression detectable at 18.5
CC dpc (PubMed:18505825). Abundantly expressed in the subventricular zone
CC of the brain at 18.5 dpc (PubMed:18505825). Expressed in the brain at
CC postnatal day 2 (PubMed:18403418). {ECO:0000269|PubMed:18403418,
CC ECO:0000269|PubMed:18505825, ECO:0000269|PubMed:20596238,
CC ECO:0000269|PubMed:9337129}.
CC -!- DISRUPTION PHENOTYPE: Mice die at birth with numerous morphological
CC abnormalities (PubMed:20596238). Incomplete separation of the heart
CC ventricles with fused aorta and pulmonary arteries (PubMed:20596238).
CC Skeletal malformations including hypoplastic sternebrae, unfused
CC vertebral bodies and hypomineralized skull (PubMed:20596238). All mice
CC have microphthalmia and open eyelids, with 50% of mice exhibiting
CC omphalocele, and 40% exhibiting cleft palate, cleft lips and a tail
CC kink (PubMed:20596238). Sox11 and Sox4 double knockout mice die in
CC utero at 10.5 dpc (PubMed:20596238). Embryos are small and unturned
CC with developmental defects such as failure of heart primordia fusion, a
CC thin and undulated neural tube, failure of limb budding and somite
CC formation, suggesting developmental arrest at 8.5 dpc
CC (PubMed:20596238). Embryos showed reduced cell proliferation and
CC increased cell death in the neural tube, branchial arches, somites and
CC reduced expression of Tead2 at 9.5 dpc (PubMed:20596238). Sox4, Sox11,
CC and Sox12 triple knockout mice show severe thinning and undulation of
CC the neural tube (PubMed:20596238). {ECO:0000269|PubMed:20596238}.
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DR EMBL; AF009414; AAB82425.1; -; mRNA.
DR EMBL; AB108675; BAC75670.1; -; mRNA.
DR EMBL; BK001484; DAA01568.1; -; mRNA.
DR EMBL; AK165693; BAE38341.1; -; mRNA.
DR EMBL; AK146514; BAE27226.1; -; mRNA.
DR EMBL; BC062095; AAH62095.1; -; mRNA.
DR EMBL; Z18960; CAA79485.1; -; mRNA.
DR CCDS; CCDS25849.1; -.
DR RefSeq; NP_033260.4; NM_009234.6.
DR AlphaFoldDB; Q7M6Y2; -.
DR SMR; Q7M6Y2; -.
DR BioGRID; 203398; 1.
DR STRING; 10090.ENSMUSP00000078070; -.
DR iPTMnet; Q7M6Y2; -.
DR PhosphoSitePlus; Q7M6Y2; -.
DR MaxQB; Q7M6Y2; -.
DR PaxDb; Q7M6Y2; -.
DR PRIDE; Q7M6Y2; -.
DR ProteomicsDB; 257379; -.
DR Antibodypedia; 625; 354 antibodies from 40 providers.
DR DNASU; 20666; -.
DR Ensembl; ENSMUST00000079063; ENSMUSP00000078070; ENSMUSG00000063632.
DR GeneID; 20666; -.
DR KEGG; mmu:20666; -.
DR UCSC; uc007nfn.2; mouse.
DR CTD; 6664; -.
DR MGI; MGI:98359; Sox11.
DR VEuPathDB; HostDB:ENSMUSG00000063632; -.
DR eggNOG; KOG0527; Eukaryota.
DR GeneTree; ENSGT00940000161652; -.
DR HOGENOM; CLU_043342_0_0_1; -.
DR InParanoid; Q7M6Y2; -.
DR OMA; TAHHGDY; -.
DR OrthoDB; 1186233at2759; -.
DR PhylomeDB; Q7M6Y2; -.
DR TreeFam; TF351735; -.
DR BioGRID-ORCS; 20666; 4 hits in 73 CRISPR screens.
DR ChiTaRS; Sox11; mouse.
DR PRO; PR:Q7M6Y2; -.
DR Proteomes; UP000000589; Chromosome 12.
DR RNAct; Q7M6Y2; protein.
DR Bgee; ENSMUSG00000063632; Expressed in rostral migratory stream and 248 other tissues.
DR Genevisible; Q7M6Y2; MM.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:MGI.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:UniProtKB.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0003211; P:cardiac ventricle formation; IMP:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0061386; P:closure of optic fissure; IMP:UniProtKB.
DR GO; GO:0061303; P:cornea development in camera-type eye; IMP:UniProtKB.
DR GO; GO:0048557; P:embryonic digestive tract morphogenesis; IMP:UniProtKB.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; IMP:UniProtKB.
DR GO; GO:0061029; P:eyelid development in camera-type eye; IMP:UniProtKB.
DR GO; GO:0021782; P:glial cell development; IMP:UniProtKB.
DR GO; GO:0014009; P:glial cell proliferation; IMP:UniProtKB.
DR GO; GO:0060022; P:hard palate development; IMP:UniProtKB.
DR GO; GO:0001822; P:kidney development; IEA:Ensembl.
DR GO; GO:0002089; P:lens morphogenesis in camera-type eye; IMP:UniProtKB.
DR GO; GO:0060174; P:limb bud formation; IMP:UniProtKB.
DR GO; GO:0060425; P:lung morphogenesis; IMP:UniProtKB.
DR GO; GO:0060548; P:negative regulation of cell death; IMP:UniProtKB.
DR GO; GO:0010629; P:negative regulation of gene expression; IMP:UniProtKB.
DR GO; GO:0060253; P:negative regulation of glial cell proliferation; IMP:UniProtKB.
DR GO; GO:0050672; P:negative regulation of lymphocyte proliferation; ISO:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR GO; GO:2000678; P:negative regulation of transcription regulatory region DNA binding; ISS:UniProtKB.
DR GO; GO:0014032; P:neural crest cell development; IMP:UniProtKB.
DR GO; GO:0001841; P:neural tube formation; IMP:UniProtKB.
DR GO; GO:0060563; P:neuroepithelial cell differentiation; IMP:UniProtKB.
DR GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR GO; GO:0003357; P:noradrenergic neuron differentiation; IMP:UniProtKB.
DR GO; GO:0014003; P:oligodendrocyte development; IEA:Ensembl.
DR GO; GO:0003151; P:outflow tract morphogenesis; IMP:UniProtKB.
DR GO; GO:0030513; P:positive regulation of BMP signaling pathway; IMP:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB.
DR GO; GO:0035332; P:positive regulation of hippo signaling; IMP:UniProtKB.
DR GO; GO:0046887; P:positive regulation of hormone secretion; IMP:UniProtKB.
DR GO; GO:2001111; P:positive regulation of lens epithelial cell proliferation; IMP:UniProtKB.
DR GO; GO:0050769; P:positive regulation of neurogenesis; IDA:UniProtKB.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; IDA:UniProtKB.
DR GO; GO:0045778; P:positive regulation of ossification; IMP:UniProtKB.
DR GO; GO:0045669; P:positive regulation of osteoblast differentiation; ISS:UniProtKB.
DR GO; GO:2000648; P:positive regulation of stem cell proliferation; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; IEA:Ensembl.
DR GO; GO:0035914; P:skeletal muscle cell differentiation; IMP:MGI.
DR GO; GO:0001501; P:skeletal system development; IMP:UniProtKB.
DR GO; GO:0060023; P:soft palate development; IMP:UniProtKB.
DR GO; GO:0061053; P:somite development; IMP:UniProtKB.
DR GO; GO:0021510; P:spinal cord development; IMP:UniProtKB.
DR GO; GO:0048485; P:sympathetic nervous system development; IMP:UniProtKB.
DR GO; GO:0060412; P:ventricular septum morphogenesis; IMP:UniProtKB.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR029551; SOX-11.
DR InterPro; IPR017386; SOX-12/11/4.
DR PANTHER; PTHR10270:SF113; PTHR10270:SF113; 1.
DR Pfam; PF00505; HMG_box; 1.
DR PIRSF; PIRSF038098; SOX-12/11/4a; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 1: Evidence at protein level;
KW Activator; Developmental protein; Differentiation; DNA-binding;
KW Neurogenesis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..395
FT /note="Transcription factor SOX-11"
FT /id="PRO_0000048751"
FT DNA_BIND 49..117
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 114..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..395
FT /note="Required for transcriptional activation activity and
FT synergistic coactivation of transcriptional activity with
FT POU3F2"
FT /evidence="ECO:0000269|PubMed:18403418"
FT COMPBIAS 114..128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 103
FT /note="E -> G (in Ref. 1; AAB82425)"
FT /evidence="ECO:0000305"
FT CONFLICT 147
FT /note="A -> T (in Ref. 1; AAB82425)"
FT /evidence="ECO:0000305"
FT CONFLICT 171
FT /note="A -> V (in Ref. 1; AAB82425)"
FT /evidence="ECO:0000305"
FT CONFLICT 177
FT /note="A -> G (in Ref. 1 and 2)"
FT /evidence="ECO:0000305"
FT CONFLICT 192..196
FT /note="EDDDE -> DEEDD (in Ref. 1; AAB82425)"
FT /evidence="ECO:0000305"
FT CONFLICT 225
FT /note="T -> A (in Ref. 1; AAB82425)"
FT /evidence="ECO:0000305"
FT CONFLICT 280..281
FT /note="QP -> EA (in Ref. 1; AAB82425)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 395 AA; 42629 MW; AFA34270A054C6C5 CRC64;
MVQQAESSEA ESNLPRDALD TEEGEFMACS PVALDESDPD WCKTASGHIK RPMNAFMVWS
KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR EAERLRLKHM ADYPDYKYRP
RKKPKTDPAA KPSAGQSPDK SAAGAKAAKG PGKKCAKLKA PAGKAGAGKA AQPGDCAAGK
AAKCVFLDDD DEDDDEDDEL QLRPKPDADD DDDEPAHSHL LPPPTQQQPP QLLRRYSVAK
VPASPTLSSA AESPEGASLY DEVRAGGRLY YSFKNITKQQ PPPAPPALSP ASSRCVSTSS
SSGSSSGSGA EDADDLMFDL SLNFSQGAHS ACEQPLGAGA AGNLSLSLVD KDLDSFSEGS
LGSHFEFPDY CTPELSEMIA GDWLEANFSD LVFTY
