SOX11_RAT
ID SOX11_RAT Reviewed; 395 AA.
AC P0C1G9; O35178; O89036; Q04889;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUN-2006, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Transcription factor SOX-11;
GN Name=Sox11;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9632656; DOI=10.1074/jbc.273.26.16050;
RA Kuhlbrodt K., Herbarth B., Sock E., Enderich J., Hermans-Borgmeyer I.,
RA Wegner M.;
RT "Cooperative function of POU proteins and SOX proteins in glial cells.";
RL J. Biol. Chem. 273:16050-16057(1998).
CC -!- FUNCTION: Transcription factor that acts as a transcriptional activator
CC (By similarity). Binds cooperatively with POU3F2/BRN2 or POU3F1/OCT6 to
CC gene promoters, which enhances transcriptional activation (By
CC similarity). Acts as a transcriptional activator of TEAD2 by binding to
CC its gene promoter and first intron (By similarity). Plays a redundant
CC role with SOX4 and SOX12 in cell survival of developing tissues such as
CC the neural tube, branchial arches and somites, thereby contributing to
CC organogenesis (By similarity). {ECO:0000250|UniProtKB:Q7M6Y2}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7M6Y2,
CC ECO:0000255|PROSITE-ProRule:PRU00267}.
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DR EMBL; AJ004858; CAA06166.1; -; mRNA.
DR RefSeq; NP_445801.1; NM_053349.1.
DR AlphaFoldDB; P0C1G9; -.
DR SMR; P0C1G9; -.
DR STRING; 10116.ENSRNOP00000040127; -.
DR PaxDb; P0C1G9; -.
DR Ensembl; ENSRNOT00000045963; ENSRNOP00000040127; ENSRNOG00000030034.
DR GeneID; 84046; -.
DR KEGG; rno:84046; -.
DR CTD; 6664; -.
DR RGD; 69351; Sox11.
DR eggNOG; KOG0527; Eukaryota.
DR GeneTree; ENSGT00940000161652; -.
DR HOGENOM; CLU_043342_0_0_1; -.
DR InParanoid; P0C1G9; -.
DR OMA; TAHHGDY; -.
DR OrthoDB; 1186233at2759; -.
DR PhylomeDB; P0C1G9; -.
DR TreeFam; TF351735; -.
DR PRO; PR:P0C1G9; -.
DR Proteomes; UP000002494; Chromosome 6.
DR Bgee; ENSRNOG00000030034; Expressed in brain and 6 other tissues.
DR Genevisible; P0C1G9; RN.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0005886; C:plasma membrane; IEA:Ensembl.
DR GO; GO:0000987; F:cis-regulatory region sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; ISO:RGD.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:RGD.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0003211; P:cardiac ventricle formation; ISS:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0008283; P:cell population proliferation; IEP:RGD.
DR GO; GO:0061386; P:closure of optic fissure; ISS:UniProtKB.
DR GO; GO:0061303; P:cornea development in camera-type eye; ISS:UniProtKB.
DR GO; GO:0048557; P:embryonic digestive tract morphogenesis; ISS:UniProtKB.
DR GO; GO:0048704; P:embryonic skeletal system morphogenesis; ISS:UniProtKB.
DR GO; GO:0061029; P:eyelid development in camera-type eye; ISS:UniProtKB.
DR GO; GO:0021782; P:glial cell development; ISS:UniProtKB.
DR GO; GO:0014009; P:glial cell proliferation; ISS:UniProtKB.
DR GO; GO:0060022; P:hard palate development; ISS:UniProtKB.
DR GO; GO:0001822; P:kidney development; IEP:RGD.
DR GO; GO:0002089; P:lens morphogenesis in camera-type eye; ISS:UniProtKB.
DR GO; GO:0060174; P:limb bud formation; ISS:UniProtKB.
DR GO; GO:0060425; P:lung morphogenesis; ISS:UniProtKB.
DR GO; GO:0060548; P:negative regulation of cell death; ISS:UniProtKB.
DR GO; GO:0010629; P:negative regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0060253; P:negative regulation of glial cell proliferation; ISS:UniProtKB.
DR GO; GO:0050672; P:negative regulation of lymphocyte proliferation; ISO:RGD.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:2000678; P:negative regulation of transcription regulatory region DNA binding; IMP:UniProtKB.
DR GO; GO:0014032; P:neural crest cell development; ISS:UniProtKB.
DR GO; GO:0001841; P:neural tube formation; ISS:UniProtKB.
DR GO; GO:0060563; P:neuroepithelial cell differentiation; ISS:UniProtKB.
DR GO; GO:0030182; P:neuron differentiation; ISO:RGD.
DR GO; GO:0003357; P:noradrenergic neuron differentiation; IMP:UniProtKB.
DR GO; GO:0014003; P:oligodendrocyte development; IEP:RGD.
DR GO; GO:0003151; P:outflow tract morphogenesis; ISS:UniProtKB.
DR GO; GO:0030513; P:positive regulation of BMP signaling pathway; ISS:UniProtKB.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISS:UniProtKB.
DR GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0035332; P:positive regulation of hippo signaling; ISS:UniProtKB.
DR GO; GO:0046887; P:positive regulation of hormone secretion; ISS:UniProtKB.
DR GO; GO:2001111; P:positive regulation of lens epithelial cell proliferation; ISS:UniProtKB.
DR GO; GO:0050769; P:positive regulation of neurogenesis; ISS:UniProtKB.
DR GO; GO:0045666; P:positive regulation of neuron differentiation; ISS:UniProtKB.
DR GO; GO:0045778; P:positive regulation of ossification; ISS:UniProtKB.
DR GO; GO:0045669; P:positive regulation of osteoblast differentiation; ISS:UniProtKB.
DR GO; GO:2000648; P:positive regulation of stem cell proliferation; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:RGD.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; ISO:RGD.
DR GO; GO:0035914; P:skeletal muscle cell differentiation; ISO:RGD.
DR GO; GO:0001501; P:skeletal system development; ISS:UniProtKB.
DR GO; GO:0060023; P:soft palate development; ISS:UniProtKB.
DR GO; GO:0061053; P:somite development; ISS:UniProtKB.
DR GO; GO:0021510; P:spinal cord development; ISS:UniProtKB.
DR GO; GO:0048485; P:sympathetic nervous system development; ISS:UniProtKB.
DR GO; GO:0060412; P:ventricular septum morphogenesis; ISS:UniProtKB.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR029551; SOX-11.
DR InterPro; IPR017386; SOX-12/11/4.
DR PANTHER; PTHR10270:SF113; PTHR10270:SF113; 1.
DR Pfam; PF00505; HMG_box; 1.
DR PIRSF; PIRSF038098; SOX-12/11/4a; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; Differentiation; DNA-binding;
KW Neurogenesis; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..395
FT /note="Transcription factor SOX-11"
FT /id="PRO_0000244267"
FT DNA_BIND 49..117
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 114..258
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 276..312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 363..395
FT /note="Required for transcriptional activation activity and
FT synergistic coactivation of transcriptional activity with
FT POU3F2"
FT /evidence="ECO:0000250|UniProtKB:Q7M6Y2"
FT COMPBIAS 114..128
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 201..218
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 291..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 395 AA; 42599 MW; 0AE6CBF6CE991D58 CRC64;
MVQQAESSEA ESNLPRDALD TEEGEFMACS PVALDESDPD WCKTASGHIK RPMNAFMVWS
KIERRKIMEQ SPDMHNAEIS KRLGKRWKML KDSEKIPFIR EAERLRLKHM ADYPDYKYRP
RKKPKTDPAA KPSAGQSPDK SAAGAKAAKG PGKKCAKLKA PAGKAGAGKA AQPGDCGAGK
AAKCVFLDDD DEEDDEDDEL QLRPKPDADD DDDEPAHSHL LPPPAQQQPP QLLRRYSVAK
VPASPTLSSA AESPEGASLY DEVRAGGRLY YSFKNITKQQ PPPAPPALSP ASSRCVSTSS
SSGSSSGSGA EDADDLMFDL SLNFSQGAHS ACEQPLGAGA AGNLSLSLVD KDLDSFSEGS
LGSHFEFPDY CTPELSEMIA GDWLEANFSD LVFTY
