ID   SOX11_XENTR             Reviewed;         383 AA.
AC   Q66JF1;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Transcription factor Sox-11;
GN   Name=sox11 {ECO:0000312|EMBL:AAH80939.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAY98914.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Qin S., Dors M., Johnson E., Bloom S., Hood L., Rowen L.;
RT   "Sequence of Xenopus tropicalis development genes.";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:AAY98914.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tail bud {ECO:0000312|EMBL:AAH80939.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that binds to the DNA sequence 5'-
CC       AACAAT-3' (By similarity). Acts as a transcriptional activator (By
CC       similarity). Plays a role together with nlk in neural induction during
CC       early embryogenesis (By similarity). {ECO:0000250|UniProtKB:Q7M6Y2,
CC       ECO:0000250|UniProtKB:Q91731}.
CC   -!- SUBUNIT: Interacts with nlk. {ECO:0000250|UniProtKB:Q91731}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q7M6Y2,
CC       ECO:0000255|PROSITE-ProRule:PRU00267}.
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DR   EMBL; AC148407; AAY98914.1; -; Genomic_DNA.
DR   EMBL; BC080939; AAH80939.1; -; mRNA.
DR   RefSeq; NP_001008053.1; NM_001008052.1.
DR   AlphaFoldDB; Q66JF1; -.
DR   SMR; Q66JF1; -.
DR   DNASU; 493415; -.
DR   Ensembl; ENSXETT00000095627; ENSXETP00000089096; ENSXETG00000038964.
DR   GeneID; 493415; -.
DR   KEGG; xtr:493415; -.
DR   CTD; 6664; -.
DR   Xenbase; XB-GENE-483418; sox11.
DR   InParanoid; Q66JF1; -.
DR   OrthoDB; 1186233at2759; -.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000038964; Expressed in neurula embryo and 13 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0007420; P:brain development; IEA:Ensembl.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0061386; P:closure of optic fissure; IEA:Ensembl.
DR   GO; GO:0002088; P:lens development in camera-type eye; IEA:Ensembl.
DR   GO; GO:0045879; P:negative regulation of smoothened signaling pathway; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; ISS:UniProtKB.
DR   GO; GO:0030182; P:neuron differentiation; IBA:GO_Central.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0046548; P:retinal rod cell development; IEA:Ensembl.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR029551; SOX-11.
DR   InterPro; IPR017386; SOX-12/11/4.
DR   PANTHER; PTHR10270:SF113; PTHR10270:SF113; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   PIRSF; PIRSF038098; SOX-12/11/4a; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; Differentiation; DNA-binding;
KW   Neurogenesis; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..383
FT                   /note="Transcription factor Sox-11"
FT                   /id="PRO_0000371505"
FT   DNA_BIND        48..116
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          1..24
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          115..174
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          197..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        158..174
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        202..221
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   383 AA;  42610 MW;  ADA238A71937D044 CRC64;
     MVQQADSLDM DSSQHTEPDT EEGEFMACSP VALDESDPDW CKTATGHIKR PMNAFMVWSK
     IERRKIMEQS PDMHNAEISK RLGKRWKMLN DSEKIPFIRE AERLRLKHMA DYPDYKYRPR
     KKPKVDPSAS KPASLAQSPE KSPKSRSAGK KCPKLKPGSH SGSSSSSGSA KSLTIKSEYG
     GDDYVFGSPK AASKAAKCVF MDEDDEEEEE DEEEDELQIR IKQEEEDEPL RQYNVAKVPA
     SPTLSSSSAE SAEGASMYED VRNGTRLYYN FKNITKQSTI PQATITLAPA PRSAGTTSPS
     SHKDELMFDL SLNFTQQNPP VPELGNPNSG NLSLSLVDKD LDSCSEGSLG SHFDFPDYCT
     PELSEMIAGD WLEANFSDLV FTY