SOX12_XENLA
ID SOX12_XENLA Reviewed; 244 AA.
AC Q8AXQ4;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Transcription factor Sox-12;
DE AltName: Full=Sox-K1 protein {ECO:0000312|EMBL:BAC41346.1};
DE Short=XSox-K1 {ECO:0000312|EMBL:BAC41346.1};
DE AltName: Full=Transcription factor Sox-33;
DE Short=xSox-33;
DE Short=xSox33 {ECO:0000303|PubMed:12890561};
GN Name=sox12;
GN Synonyms=sox-k1 {ECO:0000312|EMBL:BAC41346.1},
GN sox-k1-a {ECO:0000312|EMBL:AAI69671.1},
GN sox33 {ECO:0000303|PubMed:12890561};
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAC41346.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RX PubMed=12890561; DOI=10.1016/s0167-4781(03)00139-8;
RA Hagiuda J., Hiraoka Y., Hasegawa M., Ogawa M., Aiso S.;
RT "A novel Xenopus laevis SRY-related gene, xSox33.";
RL Biochim. Biophys. Acta 1628:140-145(2003).
RN [2] {ECO:0000312|EMBL:AAI69671.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Oocyte {ECO:0000312|EMBL:AAI69671.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor that binds to the sequence 5'-AACAAT-3'
CC (PubMed:12890561). Acts as a transcriptional activator (By similarity).
CC {ECO:0000250|UniProtKB:Q04890, ECO:0000269|PubMed:12890561}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O15370,
CC ECO:0000255|PROSITE-ProRule:PRU00267}.
CC -!- TISSUE SPECIFICITY: Expressed at a low level in embryos, and in the
CC adult lung, ovary, skeletal muscle, testis, brain and heart.
CC {ECO:0000269|PubMed:12890561}.
CC -!- DEVELOPMENTAL STAGE: Zygotic expression begins after mid-blastula and
CC expression levels rise gradually up to stage 41.
CC {ECO:0000269|PubMed:12890561}.
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DR EMBL; AB086020; BAC41346.1; -; mRNA.
DR EMBL; BC169671; AAI69671.1; -; mRNA.
DR EMBL; BC169697; AAI69697.1; -; mRNA.
DR RefSeq; NP_001079045.1; NM_001085576.1.
DR RefSeq; XP_018092641.1; XM_018237152.1.
DR AlphaFoldDB; Q8AXQ4; -.
DR SMR; Q8AXQ4; -.
DR GeneID; 373574; -.
DR KEGG; xla:373574; -.
DR CTD; 373574; -.
DR Xenbase; XB-GENE-864958; sox12.S.
DR OMA; DKEVPPH; -.
DR OrthoDB; 1186233at2759; -.
DR Proteomes; UP000186698; Chromosome 9_10S.
DR Bgee; 373574; Expressed in internal ear and 7 other tissues.
DR GO; GO:0005634; C:nucleus; IC:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:0045591; P:positive regulation of regulatory T cell differentiation; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; NAS:UniProtKB.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR017386; SOX-12/11/4.
DR Pfam; PF00505; HMG_box; 1.
DR PIRSF; PIRSF038098; SOX-12/11/4a; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..244
FT /note="Transcription factor Sox-12"
FT /id="PRO_0000370247"
FT DNA_BIND 31..99
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..137
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 152..193
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 115..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 155..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 244 AA; 27280 MW; 99C8274D1C2A8B85 CRC64;
MVQNKTTGSC PKPTEVAPGG PSWCKTSNGH IKRPMNAFMV WSQIERRKLM SLCPNMHNAD
ISRSLGQRWK LLQDTDKIPY VREAERLRLK HMADYPNYKY RPRRRSRTQE SKTRARLPRS
TATCQSVPSP CLSQMDTGSS MQWGETCPAW GGDQVGQSVE TQIRESSARS PEVPTHTKTV
PSSPQSAEEH EGLEGGSLVI PVDKEVPPHS GSHFEFPDHC TPEVMEMISG SGLLESVPDL
VFSY
