SOX13_MOUSE
ID SOX13_MOUSE Reviewed; 613 AA.
AC Q04891; Q922L3;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 09-FEB-2010, sequence version 4.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Transcription factor SOX-13;
DE AltName: Full=SRY (Sex determining region Y)-box 13;
DE Short=mSox13;
GN Name=Sox13; Synonyms=Sox-13;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 3-613, FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Embryo;
RX PubMed=9524265; DOI=10.1016/s0378-1119(97)00667-7;
RA Kido S., Hiraoka Y., Ogawa M., Sakai Y., Yoshimura Y., Aiso S.;
RT "Cloning and characterization of mouse mSox13 cDNA.";
RL Gene 208:201-206(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 19-613, FUNCTION, SUBCELLULAR LOCATION, AND
RP DEVELOPMENTAL STAGE.
RC TISSUE=Embryo;
RX PubMed=9421502; DOI=10.1093/nar/26.2.469;
RA Roose J., Korver W., Oving E., Wilson A., Wagenaar G., Markman M.,
RA Lamers W., Clevers H.;
RT "High expression of the HMG box factor sox-13 in arterial walls during
RT embryonic development.";
RL Nucleic Acids Res. 26:469-476(1998).
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 424-479.
RC STRAIN=SWR/J; TISSUE=Fetus;
RX PubMed=8441686; DOI=10.1093/nar/21.3.744;
RA Wright E.M., Snopek B., Koopman P.;
RT "Seven new members of the Sox gene family expressed during mouse
RT development.";
RL Nucleic Acids Res. 21:744-744(1993).
RN [5]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=10871192; DOI=10.2337/diabetes.49.4.555;
RA Kasimiotis H., Myers M.A., Argentaro A., Mertin S., Fida S., Ferraro T.,
RA Olsson J., Rowley M.J., Harley V.R.;
RT "Sex-determining region Y-related protein SOX13 is a diabetes autoantigen
RT expressed in pancreatic islets.";
RL Diabetes 49:555-561(2000).
RN [6]
RP SUBCELLULAR LOCATION, AND DEVELOPMENTAL STAGE.
RX PubMed=16835393; DOI=10.1369/jhc.6a6923.2006;
RA Wang Y., Ristevski S., Harley V.R.;
RT "SOX13 exhibits a distinct spatial and temporal expression pattern during
RT chondrogenesis, neurogenesis, and limb development.";
RL J. Histochem. Cytochem. 54:1327-1333(2006).
RN [7]
RP FUNCTION, INTERACTION WITH TCF7, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=17218525; DOI=10.1126/science.1135344;
RA Melichar H.J., Narayan K., Der S.D., Hiraoka Y., Gardiol N., Jeannet G.,
RA Held W., Chambers C.A., Kang J.;
RT "Regulation of gammadelta versus alphabeta T lymphocyte differentiation by
RT the transcription factor SOX13.";
RL Science 315:230-233(2007).
RN [8]
RP INTERACTION WITH HHEX.
RX PubMed=20028982; DOI=10.1074/jbc.m109.046649;
RA Marfil V., Moya M., Pierreux C.E., Castell J.V., Lemaigre F.P., Real F.X.,
RA Bort R.;
RT "Interaction between Hhex and SOX13 modulates Wnt/TCF activity.";
RL J. Biol. Chem. 285:5726-5737(2010).
RN [9]
RP FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=23562159; DOI=10.1016/j.immuni.2013.01.010;
RG Immunological Genome Project Consortium;
RA Malhotra N., Narayan K., Cho O.H., Sylvia K.E., Yin C., Melichar H.,
RA Rashighi M., Lefebvre V., Harris J.E., Berg L.J., Kang J.;
RT "A network of high-mobility group box transcription factors programs innate
RT interleukin-17 production.";
RL Immunity 38:681-693(2013).
RN [10]
RP FUNCTION, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY,
RP AND DISRUPTION PHENOTYPE.
RX PubMed=26525805; DOI=10.1111/jnc.13414;
RA Baroti T., Schillinger A., Wegner M., Stolt C.C.;
RT "Sox13 functionally complements the related Sox5 and Sox6 as important
RT developmental modulators in mouse spinal cord oligodendrocytes.";
RL J. Neurochem. 136:316-328(2016).
RN [11]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=27923061; DOI=10.1371/journal.pgen.1006474;
RA Brunmeir R., Wu J., Peng X., Kim S.Y., Julien S.G., Zhang Q., Xie W.,
RA Xu F.;
RT "Comparative Transcriptomic and Epigenomic Analyses Reveal New Regulators
RT of Murine Brown Adipogenesis.";
RL PLoS Genet. 12:E1006474-E1006474(2016).
RN [12]
RP FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, AND DISRUPTION
RP PHENOTYPE.
RX PubMed=30413363; DOI=10.1016/j.immuni.2018.09.010;
RA Spidale N.A., Sylvia K., Narayan K., Miu B., Frascoli M., Melichar H.J.,
RA Zhihao W., Kisielow J., Palin A., Serwold T., Love P., Kobayashi M.,
RA Yoshimoto M., Jain N., Kang J.;
RT "Interleukin-17-Producing gammadelta T Cells Originate from SOX13+
RT Progenitors that Are Independent of gammadeltaTCR Signaling.";
RL Immunity 49:857-872.E5(2018).
RN [13]
RP DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=30638933; DOI=10.1016/j.bbrc.2018.12.163;
RA Noto M., Noguchi N., Ishimura A., Kiyonari H., Abe T., Suzuki T.,
RA Hasunuma N., Taira M., Manabe M., Osada S.I.;
RT "Sox13 is a novel early marker for hair follicle development.";
RL Biochem. Biophys. Res. Commun. 509:862-868(2019).
CC -!- FUNCTION: Transcription factor that binds to DNA at the consensus
CC sequence 5'-AACAAT-3' (PubMed:9524265, PubMed:9421502). Binds to the
CC proximal promoter region of the myelin protein MPZ gene, and may
CC thereby be involved in the differentiation of oligodendroglia in the
CC developing spinal tube (PubMed:26525805). Binds to the gene promoter of
CC MBP and acts as a transcriptional repressor (PubMed:26525805). Binds to
CC and modifies the activity of TCF7/TCF1, thereby inhibiting
CC transcription and modulates normal gamma-delta T-cell development and
CC differentiation of IL17A expressing gamma-delta T-cells
CC (PubMed:17218525, PubMed:23562159, PubMed:30413363). Required for the
CC differentiation of Vgamma2-positive gamma-delta T-cells, a subset of
CC IL17A expressing gamma-delta T-cells (PubMed:23562159). Regulates
CC expression of BLK in the differentiation of IL17A expressing gamma-
CC delta T-cells (PubMed:23562159). Promotes brown adipocyte
CC differentiation (PubMed:27923061). Inhibitor of WNT signaling (By
CC similarity). {ECO:0000250|UniProtKB:Q9UN79,
CC ECO:0000269|PubMed:17218525, ECO:0000269|PubMed:23562159,
CC ECO:0000269|PubMed:26525805, ECO:0000269|PubMed:27923061,
CC ECO:0000269|PubMed:30413363, ECO:0000269|PubMed:9421502,
CC ECO:0000269|PubMed:9524265}.
CC -!- SUBUNIT: Homodimer; homodimerization reduces DNA binding efficiency (By
CC similarity). Interacts with isoform 2 of TCF7/TCF1 (via N-terminus);
CC inhibits WNT-mediated transcriptional activity (PubMed:17218525).
CC Interacts with HHEX (via N-terminus); abolishes the SOX13-mediated
CC inhibition of WNT-mediated transcriptional activity via competitive
CC inhibition of the SOX13-TCF7 complex (PubMed:20028982).
CC {ECO:0000250|UniProtKB:Q9UN79, ECO:0000269|PubMed:17218525,
CC ECO:0000269|PubMed:20028982}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267,
CC ECO:0000269|PubMed:10871192, ECO:0000269|PubMed:16835393,
CC ECO:0000269|PubMed:26525805, ECO:0000269|PubMed:9421502}. Cytoplasm
CC {ECO:0000269|PubMed:10871192}.
CC -!- TISSUE SPECIFICITY: Expressed in beta-cells in pancreatic islets of
CC Langerhans (at protein level) (PubMed:10871192). Expressed in a subset
CC of invariant natural killer (iNK) T-cells (at protein level)
CC (PubMed:30413363). Expressed in oligodendroglial cells in the spinal
CC cord (at protein level) (PubMed:26525805). In the hematopoietic system,
CC expressed in gamma-delta T-cell lineage, specifically in immature
CC Vgamma2-positive gamma-delta thymocytes, with expression decreasing
CC upon maturation (PubMed:17218525, PubMed:23562159, PubMed:30413363).
CC Expressed in DN1d cells, a subset of DN1 (TCR, CD4 and CD8 negative,
CC also known as TN1) thymocyte progenitors, and in DN2 (also known as
CC TN2) thymocyte progenitors (PubMed:17218525, PubMed:30413363).
CC Expressed in the ovary and kidney (PubMed:9524265). Expressed in the
CC peripheral lymphoid organs (PubMed:17218525).
CC {ECO:0000269|PubMed:10871192, ECO:0000269|PubMed:17218525,
CC ECO:0000269|PubMed:23562159, ECO:0000269|PubMed:26525805,
CC ECO:0000269|PubMed:30413363, ECO:0000269|PubMed:9524265}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the visceral mesoderm of the yolk sac
CC from 9.5 dpc to 15.5 dpc (at protein level) (PubMed:16835393,
CC PubMed:30413363). Expressed in the sclerotome of developing somites and
CC the derivative vertebrae and ribs between 9.5 dpc and 12.5 dpc
CC (PubMed:16835393). Expressed in the rostral perichondrial area and
CC mesenchyme of the limb bud in the prospective arm region and hand plate
CC at 10.5 dpc, proximal mesenchyme expression in the forelimb then
CC decreases between 11.5 dpc and 12.5 dpc until expression is
CC consolidated to the arm regions of the developing limb at 12.5 dpc and
CC forelimb digits at 13.5 dpc (PubMed:16835393). Expressed at variable
CC levels in the prospective forebrain to the hindbrain and all neural
CC tube cell layers from 9.5 dpc to postnatal day 6 (P6) (PubMed:16835393,
CC PubMed:26525805). Expressed in immature oligodendrocyte precursor cells
CC and astrocytes at 15.5 dpc, additionally expressed in precursor and
CC differentiating oligodendrocytes in the neural tube from 18.5 dpc to P6
CC (PubMed:26525805). Highly expressed in embryonic arterial walls at 13.5
CC dpc (PubMed:9421502). Low levels are found in the inner ear at 13.5 dpc
CC and in some cells in the thymus at 16.5 dpc (PubMed:9421502). Initially
CC expressed in the hair follicles of the whisker pad vibrissae at 14.5
CC dpc, expression continues in the hair placode and in hair germ and peg
CC during hair follicle morphogenesis to 18 dpc (PubMed:9421502,
CC PubMed:30638933). Expressed in the newborn hair follicle epithelial
CC sheath, this expression weakens at P15, reexpressed in the hair
CC follicle bulge and secondary germ regions at P22, with expression
CC continuing in the root sheath of the hair follicle at P28
CC (PubMed:30638933). Expressed in trophoblast giant cells of the
CC spongiotrophoblast and labyrinth layers of the placenta at 15.5 dpc
CC (PubMed:16835393). Expressed in DN1d cells, a subset of DN1 precursor
CC thymocytes, from 16 dpc onwards (PubMed:30413363). Expressed in the
CC tracheal epithelium below the vocal cord at 18 dpc (PubMed:9421502).
CC Expression is transiently increased during brown adipocyte
CC differentiation (PubMed:27923061). {ECO:0000269|PubMed:16835393,
CC ECO:0000269|PubMed:26525805, ECO:0000269|PubMed:27923061,
CC ECO:0000269|PubMed:30413363, ECO:0000269|PubMed:30638933,
CC ECO:0000269|PubMed:9421502}.
CC -!- DISRUPTION PHENOTYPE: Mice show severe growth abnormalities
CC (PubMed:17218525). Severe reduction in the number of Rorc and Vgamma2-
CC positive mature thymocytes in fetal and adult mice caused by the loss
CC of Blk expression in Vgamma2-positive immature thymocytes
CC (PubMed:23562159). This results in a severe reduction of Il17a-
CC producing Vgamma2-positive gamma-delta T-cells in the spleen, lymph
CC nodes and dermis (PubMed:17218525, PubMed:23562159). In addition, the
CC number of Vgamma4-positive thymocytes in the fetal thymus is
CC transiently reduced, with levels returning to normal in neonatal and
CC adult mice (PubMed:23562159). Proliferation of CD3, CD4, and CD8-
CC negative (triple negative) thymocytes and gamma-delta thymocytes is
CC increased (PubMed:17218525). Double knockout of Sox13 and Tcf7/Tcf1
CC shows a reduced number of DN1d cells (PubMed:30413363). No defects in
CC oligodendrocyte precursor cells specification and in their
CC differentiation into myelinating oligodendrocytes (PubMed:26525805).
CC However, in Sox13 and Sox6 double knockout mice, causes a slight
CC increase in the number of prematurely differentiated oligodendrocytes
CC in the spinal tube compared to Sox6 knockout mice (PubMed:26525805). No
CC defects in the integumentary system morphology and in hair development
CC (PubMed:30638933). {ECO:0000269|PubMed:17218525,
CC ECO:0000269|PubMed:23562159, ECO:0000269|PubMed:26525805,
CC ECO:0000269|PubMed:30413363, ECO:0000269|PubMed:30638933}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH07130.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAA25786.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAA04278.1; Type=Miscellaneous discrepancy; Note=Several frameshifts.; Evidence={ECO:0000305};
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DR EMBL; BC007130; AAH07130.1; ALT_INIT; mRNA.
DR EMBL; AB006329; BAA25786.1; ALT_INIT; mRNA.
DR EMBL; AJ000740; CAA04278.1; ALT_SEQ; mRNA.
DR EMBL; Z18962; CAA79487.1; -; mRNA.
DR CCDS; CCDS48363.1; -.
DR PIR; JC6550; JC6550.
DR PIR; S30241; S30241.
DR RefSeq; NP_035569.2; NM_011439.2.
DR AlphaFoldDB; Q04891; -.
DR SMR; Q04891; -.
DR STRING; 10090.ENSMUSP00000119729; -.
DR iPTMnet; Q04891; -.
DR PhosphoSitePlus; Q04891; -.
DR MaxQB; Q04891; -.
DR PaxDb; Q04891; -.
DR PRIDE; Q04891; -.
DR ProteomicsDB; 261477; -.
DR Antibodypedia; 11334; 189 antibodies from 30 providers.
DR DNASU; 20668; -.
DR Ensembl; ENSMUST00000094551; ENSMUSP00000092130; ENSMUSG00000070643.
DR Ensembl; ENSMUST00000153799; ENSMUSP00000119729; ENSMUSG00000070643.
DR GeneID; 20668; -.
DR KEGG; mmu:20668; -.
DR UCSC; uc007cqk.1; mouse.
DR CTD; 9580; -.
DR MGI; MGI:98361; Sox13.
DR VEuPathDB; HostDB:ENSMUSG00000070643; -.
DR eggNOG; KOG0528; Eukaryota.
DR GeneTree; ENSGT00940000158759; -.
DR InParanoid; Q04891; -.
DR OMA; KMSNCGP; -.
DR OrthoDB; 465521at2759; -.
DR PhylomeDB; Q04891; -.
DR TreeFam; TF320471; -.
DR Reactome; R-MMU-3769402; Deactivation of the beta-catenin transactivating complex.
DR BioGRID-ORCS; 20668; 2 hits in 73 CRISPR screens.
DR PRO; PR:Q04891; -.
DR Proteomes; UP000000589; Chromosome 1.
DR RNAct; Q04891; protein.
DR Bgee; ENSMUSG00000070643; Expressed in saccule of membranous labyrinth and 177 other tissues.
DR ExpressionAtlas; Q04891; baseline and differential.
DR Genevisible; Q04891; MM.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003677; F:DNA binding; ISO:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001217; F:DNA-binding transcription repressor activity; IDA:UniProtKB.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISS:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; ISS:UniProtKB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISO:MGI.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0042492; P:gamma-delta T cell differentiation; IMP:UniProtKB.
DR GO; GO:0090090; P:negative regulation of canonical Wnt signaling pathway; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISO:MGI.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISO:MGI.
DR GO; GO:0090336; P:positive regulation of brown fat cell differentiation; IMP:UniProtKB.
DR GO; GO:0045588; P:positive regulation of gamma-delta T cell differentiation; IMP:UniProtKB.
DR GO; GO:0045586; P:regulation of gamma-delta T cell differentiation; IDA:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:0021529; P:spinal cord oligodendrocyte cell differentiation; IGI:UniProtKB.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR029547; SOX-13.
DR PANTHER; PTHR45789:SF4; PTHR45789:SF4; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Differentiation; DNA-binding; Nucleus; Phosphoprotein;
KW Reference proteome; Repressor; Transcription; Transcription regulation.
FT CHAIN 1..613
FT /note="Transcription factor SOX-13"
FT /id="PRO_0000048757"
FT DNA_BIND 416..484
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 1..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 77..336
FT /note="Required for homodimerization"
FT /evidence="ECO:0000250|UniProtKB:Q9UN79"
FT REGION 276..329
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 572..613
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 59..73
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..591
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 327
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UN79"
FT MOD_RES 374
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UN79"
FT MOD_RES 377
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UN79"
FT MOD_RES 378
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UN79"
FT MOD_RES 604
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9UN79"
FT CONFLICT 3
FT /note="M -> L (in Ref. 2; BAA25786)"
FT /evidence="ECO:0000305"
FT CONFLICT 53
FT /note="L -> P (in Ref. 1; AAH07130)"
FT /evidence="ECO:0000305"
FT CONFLICT 59..60
FT /note="TN -> AT (in Ref. 1; AAH07130)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 613 AA; 68168 MW; F62C88A052436E91 CRC64;
MSMQSPVSVQ LAPDSASTMV NCTIKSEEKK EPCHEAPQGA APAVETQPGD PALASQDATN
AKAPPQDCAS PESSGSPEPK RPAASEAASG SQERLDFNRN LQEVVPAIEK LLSSDWKERF
LGRSNVEAKD VKGTQESLAE KELQLLVMIH QLSALRDQLL TAHSEQKNMA AMLFEKQQQQ
MELARQQQEQ IAKQQQQLIQ QQHKINLLQQ QIQQVNMPYV MIPAFPPSHQ PLPVTPDSQL
ALPIQPIPCK PVEYPLQLLH SPPAPVVKRS GVAAHHPLQE PPQPLNLTAK PKVPELPNTS
SSPSLKMNSC GPRPASHGAP TRDLQSSPPS LPLGFLGEGD AVTKAIQDAR QLLHSHSGAL
ENSPNTPFRK DLISLDSSPA KERLEESCVH PLEEAMLSCD MDGSRHFSES RNSSHIKRPM
NAFMVWAKDE RRKILQAFPD MHNSSISKIL GSRWKSMTNQ EKQPYYEEQA RLSRQHLEKY
PDYKYKPRPK RTCVVEGRRL RVGEYKALMR TRRQGARQSY TIPPQAGQAQ VSSDILFPRA
AGLPLARPLV EHYDPQGLDP NMPVIINTCS LREEGEGTDD RHSVADGEMY RYSEDEDSEG
DEKSDEELVV LTD
