ID   SOX13_XENLA             Reviewed;         567 AA.
AC   P40649; Q6NUE6;
DT   01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 3.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Transcription factor Sox-13;
DE   AltName: Full=Transcription factor Sox-12;
DE            Short=xSox-12;
DE            Short=xSox12;
GN   Name=sox13; Synonyms=sox12;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Oocyte;
RX   PubMed=8597594; DOI=10.1016/0167-4781(95)00228-6;
RA   Komatsu N., Hiraoka Y., Shiozawa M., Ogawa M., Aiso S.;
RT   "Cloning and expression of Xenopus laevis xSox12 cDNA.";
RL   Biochim. Biophys. Acta 1305:117-119(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 403-456.
RC   TISSUE=Oocyte;
RX   PubMed=1614875; DOI=10.1093/nar/20.11.2887;
RA   Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A.;
RT   "A conserved family of genes related to the testis determining gene, SRY.";
RL   Nucleic Acids Res. 20:2887-2887(1992).
CC   -!- FUNCTION: Transcription factor that binds to DNA at the consensus
CC       sequence 5'-AACAAT-3'. {ECO:0000250|UniProtKB:Q04891}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9UN79}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC   -!- TISSUE SPECIFICITY: Expression is highest in the ovary, with weak
CC       expression in other adult tissues. {ECO:0000269|PubMed:8597594}.
CC   -!- CAUTION: Was originally termed sox-12 (PubMed:8597594 and
CC       PubMed:1614875). {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA09119.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; D50552; BAA09119.1; ALT_FRAME; mRNA.
DR   EMBL; BC068647; AAH68647.1; -; mRNA.
DR   EMBL; X65655; CAA46606.1; -; mRNA.
DR   PIR; S71466; S71466.
DR   RefSeq; NP_001081238.1; NM_001087769.1.
DR   AlphaFoldDB; P40649; -.
DR   SMR; P40649; -.
DR   MaxQB; P40649; -.
DR   GeneID; 397727; -.
DR   KEGG; xla:397727; -.
DR   CTD; 397727; -.
DR   Xenbase; XB-GENE-865496; sox13.S.
DR   OrthoDB; 465521at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 397727; Expressed in internal ear and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR029547; SOX-13.
DR   PANTHER; PTHR45789:SF4; PTHR45789:SF4; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..567
FT                   /note="Transcription factor Sox-13"
FT                   /id="PRO_0000048777"
FT   DNA_BIND        392..460
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          66..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          249..307
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          490..513
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        257..307
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        483
FT                   /note="A -> V (in Ref. 1; BAA09119)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   567 AA;  63408 MW;  4C81BAA6138179F1 CRC64;
     MDTIQGELVY CPANEQECRI SAKIPISPSE DTGGPCLKVE EDYEEVSLQT GIVPVFIKQD
     YESSSQDAND LCKPQGDAPA SDRKEENLKL SKTVSDAMPA LEKFLSNDWK EILLGNSTVG
     SKDFKGTKES LAEKELQLLL MIHQLTGLRD QLLSAHSEHR NLAAMLFEKQ QQQMDLARQQ
     QEQIAKQQQQ LIQQQHKINM LQQQIQQVNM PYVMIPAFPS AQTVSAEPQM SLPIQPIPCK
     PVEYPMPLLH NSHAGRGSAS AKHQETSQPL NLTAKPKCPD QFPNSSSSPE FRMSPVGSQC
     GGTMDSASSS QKANLPLGFL GEGDAITKAI QEACQLLHGQ NTSPEHCQQN YRKELLDTLP
     EKNIQDVTSL HHTEASLLRC SMDIDGSRGN HIKRPMNAFM VWAKDERRKI LQAFPDMHNS
     SISKILGSRW KSMSNGEKQP YYEEQARLSR QHLERYPDYK YKPRPKRTCI VEGKRLRVGE
     YKALMKNRRQ DTRSLGSLQC PPSPSGFSSQ SLLGNLSQSP QECNIQVVTS QCLMSHELHG
     AIHMAKDICS DSEDSVKSDG ELVVITD