ID   SOX13_XENTR             Reviewed;         566 AA.
AC   Q28EW4;
DT   05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Transcription factor Sox-13;
GN   Name=sox13; ORFNames=TGas067m20.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:CAJ83449.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula {ECO:0000312|EMBL:CAJ83449.1};
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor that binds to DNA at the consensus
CC       sequence 5'-AACAAT-3'. {ECO:0000250|UniProtKB:Q04891}.
CC   -!- SUBUNIT: Homodimer. {ECO:0000250|UniProtKB:Q9UN79}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q04891,
CC       ECO:0000255|PROSITE-ProRule:PRU00267}.
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DR   EMBL; CR762311; CAJ83449.1; -; mRNA.
DR   RefSeq; NP_001017004.1; NM_001017004.2.
DR   AlphaFoldDB; Q28EW4; -.
DR   SMR; Q28EW4; -.
DR   STRING; 8364.ENSXETP00000037344; -.
DR   PaxDb; Q28EW4; -.
DR   GeneID; 549758; -.
DR   KEGG; xtr:549758; -.
DR   CTD; 9580; -.
DR   Xenbase; XB-GENE-481889; sox13.
DR   eggNOG; KOG0528; Eukaryota.
DR   HOGENOM; CLU_018522_1_1_1; -.
DR   InParanoid; Q28EW4; -.
DR   OrthoDB; 465521at2759; -.
DR   Reactome; R-XTR-3769402; Deactivation of the beta-catenin transactivating complex.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR029547; SOX-13.
DR   PANTHER; PTHR45789:SF4; PTHR45789:SF4; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..566
FT                   /note="Transcription factor Sox-13"
FT                   /id="PRO_0000371506"
FT   DNA_BIND        378..446
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          47..69
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          242..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          545..566
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        52..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        242..299
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   566 AA;  63710 MW;  8977701E462ECFC0 CRC64;
     MDNLQGELVS FPASQQECRI SAKIPVSPSE GIEGHCFKVE EDYEEPALQS GTPPFFTKQD
     YESPPQDTND LCELQADSSG SGRKEENLQL SKTVRDAMPA LEKLLSNDWR EILLGTKESL
     AEKELQLLFM IHQLTRLRDQ LLSAHSEHRN MAAMLFEKQQ QQMELARQQQ EQIVKQQQQL
     IQQQHKINLL QQQIQHVNMP YVMIPAFPPA QTVTADPQMS LPIQPIPCKP VEYPMSLLHN
     STTRGSVSAK RQETSQPLNL TAKPTDQVPN SRSSPKYRMS PVGSQGGSSM DSASSPQKAN
     LPLGFLGEGD AITKAIQEAC QLLHGQNTSP EHHQQKYRKE LLDTLPEKEV QDGASLQHTE
     ESVLGCNMDI DGSRGSHIKR PMNAFMVWAK DERRKILQAF PDMHNSSISK ILGSRWKSMS
     NAEKQPYYEE QARLSRQHLE RYPDYKYKPR PKRTCIVEGK RLRVGEYKAL MKNRRQDTRQ
     GYVITSIGAL QCPPSPSGFS SQSLLDNLSQ LPSSDHYNPQ DCNIQVVKSH LLVSHEPHGA
     IPMAKDICSD SEDSGKSDGE LVVITD