SOX14_CHICK
ID SOX14_CHICK Reviewed; 240 AA.
AC Q9W7R6; P40672;
DT 01-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Transcription factor SOX-14;
DE AltName: Full=SRY-related protein CH60;
GN Name=SOX14;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031 {ECO:0000312|EMBL:AAF61300.2};
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Liver;
RX PubMed=10473124; DOI=10.1016/s0925-4773(99)00083-0;
RA Uchikawa M., Kamachi Y., Kondoh H.;
RT "Two distinct subgroups of Group B Sox genes for transcriptional activators
RT and repressors: their expression during embryonic organogenesis of the
RT chicken.";
RL Mech. Dev. 84:103-120(1999).
RN [2] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=10677261; DOI=10.1006/dbio.1999.9581;
RA Hargrave M., Karunaratne A., Cox L., Wood S., Koopman P., Yamada T.;
RT "The HMG box transcription factor gene Sox14 marks a novel subset of
RT ventral interneurons and is regulated by sonic hedgehog.";
RL Dev. Biol. 219:142-153(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 26-79.
RC TISSUE=Blood;
RX PubMed=8443573; DOI=10.1101/gr.2.3.218;
RA Coriat A.M., Mueller U., Harry J.L., Uwanogho D., Sharpe P.T.;
RT "PCR amplification of SRY-related gene sequences reveals evolutionary
RT conservation of the SRY-box motif.";
RL PCR Methods Appl. 2:218-222(1993).
CC -!- FUNCTION: Acts as a negative regulator of transcription.
CC {ECO:0000269|PubMed:10473124}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Highly expressed in developing brain and spinal
CC cord. {ECO:0000269|PubMed:10473124, ECO:0000269|PubMed:10677261}.
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DR EMBL; AB026622; BAA77265.1; -; Genomic_DNA.
DR EMBL; AF193760; AAF61300.2; -; mRNA.
DR EMBL; M86326; AAA48683.1; -; Genomic_DNA.
DR PIR; I50196; I50196.
DR RefSeq; NP_990092.1; NM_204761.1.
DR AlphaFoldDB; Q9W7R6; -.
DR SMR; Q9W7R6; -.
DR STRING; 9031.ENSGALP00000028003; -.
DR PaxDb; Q9W7R6; -.
DR Ensembl; ENSGALT00000060266; ENSGALP00000048810; ENSGALG00000037352.
DR GeneID; 395526; -.
DR KEGG; gga:395526; -.
DR CTD; 8403; -.
DR VEuPathDB; HostDB:geneid_395526; -.
DR eggNOG; KOG0527; Eukaryota.
DR GeneTree; ENSGT00940000160749; -.
DR InParanoid; Q9W7R6; -.
DR OMA; NCTAWST; -.
DR OrthoDB; 1335452at2759; -.
DR PhylomeDB; Q9W7R6; -.
DR PRO; PR:Q9W7R6; -.
DR Proteomes; UP000000539; Chromosome 9.
DR GO; GO:0005634; C:nucleus; IC:UniProtKB.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0009649; P:entrainment of circadian clock; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:2001222; P:regulation of neuron migration; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; IEA:Ensembl.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR029549; SOX-14.
DR InterPro; IPR022097; SOX_fam.
DR PANTHER; PTHR10270:SF107; PTHR10270:SF107; 1.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12336; SOXp; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..240
FT /note="Transcription factor SOX-14"
FT /id="PRO_0000048761"
FT DNA_BIND 8..76
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 19..38
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 72
FT /note="H -> Y (in Ref. 3; AAA48683)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 240 AA; 26666 MW; D62BD24721C77319 CRC64;
MSKPSDHIKR PMNAFMVWSR GQRRKMAQEN PKMHNSEISK RLGAEWKLLS EAEKRPYIDE
AKRLRAQHMK EHPDYKYRPR RKPKNLLKKD RYVFPLPYLG ETDPLKAAGL PVGATDSLLS
SPEKARAFLP PTSAPYSLLD PSQFSSSAIQ KMTEVPHTLA TGTLPYASTL GYQNGAFGSL
SCPSQHTHTH PSPTNPGYVV PCNCTAWSAS SLQPPVAYIL FPGMTKTGID PYSSAHATAM
