ID   SOX14_DANRE             Reviewed;         238 AA.
AC   Q32PP9;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   06-DEC-2005, sequence version 1.
DT   03-AUG-2022, entry version 95.
DE   RecName: Full=Transcription factor Sox-14 {ECO:0000250|UniProtKB:Q9W7R6};
GN   Name=sox14 {ECO:0000312|ZFIN:ZDB-GENE-051113-268}; ORFNames=zgc:123197;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000312|EMBL:AAI08034.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000312|EMBL:AAI08034.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (OCT-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a negative regulator of transcription. May function
CC       as a switch in neuronal development (By similarity).
CC       {ECO:0000250|UniProtKB:B0ZTE2, ECO:0000250|UniProtKB:Q9W7R6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9W7R6,
CC       ECO:0000255|PROSITE-ProRule:PRU00267}.
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DR   EMBL; BC108033; AAI08034.1; -; mRNA.
DR   RefSeq; NP_001032769.1; NM_001037680.1.
DR   AlphaFoldDB; Q32PP9; -.
DR   SMR; Q32PP9; -.
DR   STRING; 7955.ENSDARP00000095305; -.
DR   PaxDb; Q32PP9; -.
DR   Ensembl; ENSDART00000104532; ENSDARP00000095305; ENSDARG00000070929.
DR   GeneID; 557661; -.
DR   KEGG; dre:557661; -.
DR   CTD; 8403; -.
DR   ZFIN; ZDB-GENE-051113-268; sox14.
DR   eggNOG; KOG0527; Eukaryota.
DR   GeneTree; ENSGT00940000160749; -.
DR   HOGENOM; CLU_021123_3_1_1; -.
DR   InParanoid; Q32PP9; -.
DR   OMA; NCTAWST; -.
DR   OrthoDB; 1335452at2759; -.
DR   PhylomeDB; Q32PP9; -.
DR   TreeFam; TF351735; -.
DR   Reactome; R-DRE-3769402; Deactivation of the beta-catenin transactivating complex.
DR   PRO; PR:Q32PP9; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 6.
DR   Bgee; ENSDARG00000070929; Expressed in brain and 8 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0021854; P:hypothalamus development; IMP:ZFIN.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR029549; SOX-14.
DR   InterPro; IPR022097; SOX_fam.
DR   PANTHER; PTHR10270:SF107; PTHR10270:SF107; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   Pfam; PF12336; SOXp; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..238
FT                   /note="Transcription factor Sox-14"
FT                   /id="PRO_0000378068"
FT   DNA_BIND        8..76
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
SQ   SEQUENCE   238 AA;  26547 MW;  57D3173D700201FC CRC64;
     MSKPADHIKR PMNAFMVWSR GQRRKMAQEN PKMHNSEISK RLGAEWKLLS ESEKRPYIDE
     AKRLRAQHMK EHPDYKYRPR RKPKNLLKKD RYVFPLPYLG DTDHLKGLPV SATDSLLGSS
     EKARAFLPPT SAPYSFLDPS QFSSSAIQKM TEMPHTLATS TLPYASSLGY QNGAFGSLGC
     PSQHTHTHPS PTNPGYVVPC NCTAWSASSL QPPVAYILFP GMTKSGIDPY SSAHAAAM