SOX14_DROME
ID SOX14_DROME Reviewed; 669 AA.
AC P40656; Q2MGM9; Q9U1H4; Q9W1E2; Q9W1E3;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2006, sequence version 3.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Putative transcription factor SOX-14;
GN Name=Sox14; ORFNames=CG3090;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-542.
RA Cremazy F., Berta P., Girard F.;
RT "Cloning of Sox14, a new Drosophila sox gene.";
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 198-251.
RC STRAIN=Canton-S; TISSUE=Embryo;
RX PubMed=1614875; DOI=10.1093/nar/20.11.2887;
RA Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A.;
RT "A conserved family of genes related to the testis determining gene, SRY.";
RL Nucleic Acids Res. 20:2887-2887(1992).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB64387.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AE013599; AAM68286.1; -; Genomic_DNA.
DR EMBL; AJ252125; CAB64387.1; ALT_FRAME; mRNA.
DR EMBL; X65667; CAA46618.1; -; mRNA.
DR PIR; S22935; S22935.
DR RefSeq; NP_001286801.1; NM_001299872.1.
DR RefSeq; NP_476894.1; NM_057546.3.
DR RefSeq; NP_599117.1; NM_134290.1.
DR AlphaFoldDB; P40656; -.
DR SMR; P40656; -.
DR BioGRID; 63408; 4.
DR IntAct; P40656; 2.
DR STRING; 7227.FBpp0072066; -.
DR PaxDb; P40656; -.
DR EnsemblMetazoa; FBtr0072157; FBpp0072066; FBgn0005612.
DR EnsemblMetazoa; FBtr0072158; FBpp0072067; FBgn0005612.
DR EnsemblMetazoa; FBtr0343282; FBpp0309947; FBgn0005612.
DR GeneID; 37822; -.
DR KEGG; dme:Dmel_CG3090; -.
DR CTD; 8403; -.
DR FlyBase; FBgn0005612; Sox14.
DR VEuPathDB; VectorBase:FBgn0005612; -.
DR eggNOG; KOG0527; Eukaryota.
DR eggNOG; KOG1703; Eukaryota.
DR GeneTree; ENSGT00940000172703; -.
DR HOGENOM; CLU_025599_0_0_1; -.
DR InParanoid; P40656; -.
DR OMA; DGGHTFQ; -.
DR OrthoDB; 498719at2759; -.
DR PhylomeDB; P40656; -.
DR Reactome; R-DME-3769402; Deactivation of the beta-catenin transactivating complex.
DR BioGRID-ORCS; 37822; 0 hits in 3 CRISPR screens.
DR ChiTaRS; Sox14; fly.
DR GenomeRNAi; 37822; -.
DR PRO; PR:P40656; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0005612; Expressed in saliva-secreting gland and 33 other tissues.
DR ExpressionAtlas; P40656; baseline and differential.
DR Genevisible; P40656; DM.
DR GO; GO:0005634; C:nucleus; IMP:FlyBase.
DR GO; GO:0008301; F:DNA binding, bending; IDA:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:FlyBase.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0048813; P:dendrite morphogenesis; IGI:FlyBase.
DR GO; GO:0007552; P:metamorphosis; IMP:FlyBase.
DR GO; GO:0016322; P:neuron remodeling; IGI:FlyBase.
DR GO; GO:1904801; P:positive regulation of neuron remodeling; IMP:FlyBase.
DR GO; GO:1904799; P:regulation of neuron remodeling; IMP:FlyBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IMP:FlyBase.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..669
FT /note="Putative transcription factor SOX-14"
FT /id="PRO_0000048803"
FT DNA_BIND 187..255
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 1..149
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 254..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 419..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 48..69
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 70..88
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 124..142
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 278..324
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..436
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 102..110
FT /note="APKTPKTPE -> STEDPQDPG (in Ref. 3; CAB64387)"
FT /evidence="ECO:0000305"
FT CONFLICT 120..121
FT /note="Missing (in Ref. 3; CAB64387)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 669 AA; 72742 MW; 4C748614764B1E64 CRC64;
MIAKPNQATT EPPLSLRPGT VPTVPATTPA RPATITIQRR HPAPKADSTP HTLPPFSPSP
SPASSPSPAP AQTPGAQKTQ SQAAITHPAA VASPSAPVAA AAPKTPKTPE PRSTHTHTHT
HSQHFSPPPR ESEMDGERSP SHSGHEMTLS MDGIDSSLVF GSARVPVNSS TPYSDATRTK
KHSPGHIKRP MNAFMVWSQM ERRKICERTP DLHNAEISKE LGRRWQLLSK DDKQPYIIEA
EKLRKLHMIE YPNYKYRPQK KQTRSPGSLK PNQDADGCEA RNDTTNNNNS LTTLAINGTT
TAGRKSKRST STCQSGSASK RLRNDSGDTS SKPKYEVKME SAEQLNSADI ILPSADNLIS
YQSSEYLPLS TLSNADCDEK LHSELSSGPL ESRENLSEVV NRFLPLFLGG NEDSQLGVSS
LTQSQHNQSD PTAGLMDNIS DISPINDREE LTEEVMRYLP YLEVNPSSDG LTLKVESSSL
LGKPLNEPVF DSEDNIVNDA NLHSASHQIP PYVPDSHDCF AEDCGGDSSS HQVEFEVVRP
QTVTMTMTCT LPYGGPDAGH TTFQADDFNA IPSAAEDSEC SILTTSNSPQ IGFNGSSFVE
ADAIGSTCTY AQQDYTGSVI ETHNDLNYAA HDNNGALLAY TFEDLPPQPT GSHLEFNTNK
YEFASYYKM
