SOX14_HUMAN
ID SOX14_HUMAN Reviewed; 240 AA.
AC O95416; B2RAC0; Q3KPH7;
DT 30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 175.
DE RecName: Full=Transcription factor SOX-14;
DE AltName: Full=Protein SOX-28;
GN Name=SOX14; Synonyms=SOX28;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10441749; DOI=10.1007/s003359901118;
RA Malas S., Duthie S., Deloukas P., Episkopou V.;
RT "The isolation and high-resolution chromosomal mapping of human SOX14 and
RT SOX21; two members of the SOX gene family related to SOX1, SOX2, and
RT SOX3.";
RL Mamm. Genome 10:934-937(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=9925951; DOI=10.1159/000015149;
RA Arsic N., Rajic T., Stanojcic S., Goodfellow P.N., Stevanovic M.;
RT "Characterisation and mapping of the human SOX14 gene.";
RL Cytogenet. Cell Genet. 83:139-146(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=10830911; DOI=10.1007/s004390000266;
RA Hargrave M., James K., Nield K., Toomes C., Georgas K., Sullivan T.,
RA Verzijl H.T., Oley C.A., Little M., De Jonghe P., Kwon J.M., Kremer H.,
RA Dixon M.J., Timmerman V., Yamada T., Koopman P.;
RT "Fine mapping of the neurally expressed gene SOX14 to human 3q23, relative
RT to three congenital diseases.";
RL Hum. Genet. 106:432-439(2000).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Substantia nigra;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 19-72.
RX PubMed=9827568; DOI=10.1016/s0014-5793(98)01294-0;
RA Cremazy F., Soullier S., Berta P., Jay P.;
RT "Further complexity of the human SOX gene family revealed by the combined
RT use of highly degenerate primers and nested PCR.";
RL FEBS Lett. 438:311-314(1998).
CC -!- FUNCTION: Acts as a negative regulator of transcription. {ECO:0000250}.
CC -!- INTERACTION:
CC O95416; O00213-2: APBB1; NbExp=3; IntAct=EBI-9087806, EBI-13307975;
CC O95416; P54253: ATXN1; NbExp=3; IntAct=EBI-9087806, EBI-930964;
CC O95416; P54252: ATXN3; NbExp=3; IntAct=EBI-9087806, EBI-946046;
CC O95416; O43186: CRX; NbExp=3; IntAct=EBI-9087806, EBI-748171;
CC O95416; O75593: FOXH1; NbExp=3; IntAct=EBI-9087806, EBI-1759806;
CC O95416; P28799-2: GRN; NbExp=3; IntAct=EBI-9087806, EBI-25860013;
CC O95416; P42858: HTT; NbExp=12; IntAct=EBI-9087806, EBI-466029;
CC O95416; Q3LI76: KRTAP15-1; NbExp=3; IntAct=EBI-9087806, EBI-11992140;
CC O95416; Q69YI7: NAIF1; NbExp=4; IntAct=EBI-9087806, EBI-10249231;
CC O95416; P04150: NR3C1; NbExp=3; IntAct=EBI-9087806, EBI-493507;
CC O95416; P49810: PSEN2; NbExp=3; IntAct=EBI-9087806, EBI-2010251;
CC O95416; Q01974: ROR2; NbExp=5; IntAct=EBI-9087806, EBI-6422642;
CC O95416; Q96LM6: TEX37; NbExp=3; IntAct=EBI-9087806, EBI-743976;
CC O95416; P21980-2: TGM2; NbExp=3; IntAct=EBI-9087806, EBI-25842075;
CC O95416; P31930: UQCRC1; NbExp=3; IntAct=EBI-9087806, EBI-1052596;
CC O95416; O95231: VENTX; NbExp=3; IntAct=EBI-9087806, EBI-10191303;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
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DR EMBL; AF107043; AAC95380.1; -; Genomic_DNA.
DR EMBL; AJ006230; CAB43111.1; -; Genomic_DNA.
DR EMBL; AF193436; AAF76294.1; -; Genomic_DNA.
DR EMBL; AK314127; BAG36817.1; -; mRNA.
DR EMBL; CH471052; EAW79097.1; -; Genomic_DNA.
DR EMBL; BC106729; AAI06730.1; -; mRNA.
DR EMBL; BC106730; AAI06731.1; -; mRNA.
DR EMBL; AF032451; AAC94971.1; -; Genomic_DNA.
DR CCDS; CCDS3094.1; -.
DR RefSeq; NP_004180.1; NM_004189.3.
DR AlphaFoldDB; O95416; -.
DR SMR; O95416; -.
DR BioGRID; 113991; 10.
DR IntAct; O95416; 19.
DR STRING; 9606.ENSP00000305343; -.
DR iPTMnet; O95416; -.
DR PhosphoSitePlus; O95416; -.
DR BioMuta; SOX14; -.
DR jPOST; O95416; -.
DR MassIVE; O95416; -.
DR MaxQB; O95416; -.
DR PaxDb; O95416; -.
DR PeptideAtlas; O95416; -.
DR PRIDE; O95416; -.
DR Antibodypedia; 17867; 155 antibodies from 25 providers.
DR DNASU; 8403; -.
DR Ensembl; ENST00000306087.3; ENSP00000305343.1; ENSG00000168875.3.
DR GeneID; 8403; -.
DR KEGG; hsa:8403; -.
DR MANE-Select; ENST00000306087.3; ENSP00000305343.1; NM_004189.4; NP_004180.1.
DR UCSC; uc003erm.3; human.
DR CTD; 8403; -.
DR DisGeNET; 8403; -.
DR GeneCards; SOX14; -.
DR HGNC; HGNC:11193; SOX14.
DR HPA; ENSG00000168875; Tissue enriched (brain).
DR MIM; 604747; gene.
DR neXtProt; NX_O95416; -.
DR OpenTargets; ENSG00000168875; -.
DR PharmGKB; PA36030; -.
DR VEuPathDB; HostDB:ENSG00000168875; -.
DR eggNOG; KOG0527; Eukaryota.
DR GeneTree; ENSGT00940000160749; -.
DR HOGENOM; CLU_021123_3_1_1; -.
DR InParanoid; O95416; -.
DR OMA; NCTAWST; -.
DR OrthoDB; 1335452at2759; -.
DR PhylomeDB; O95416; -.
DR TreeFam; TF351735; -.
DR PathwayCommons; O95416; -.
DR SignaLink; O95416; -.
DR BioGRID-ORCS; 8403; 13 hits in 1082 CRISPR screens.
DR GeneWiki; SOX14; -.
DR GenomeRNAi; 8403; -.
DR Pharos; O95416; Tbio.
DR PRO; PR:O95416; -.
DR Proteomes; UP000005640; Chromosome 3.
DR RNAct; O95416; protein.
DR Bgee; ENSG00000168875; Expressed in placenta and 7 other tissues.
DR Genevisible; O95416; HS.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IDA:ARUK-UCL.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0009649; P:entrainment of circadian clock; IEA:Ensembl.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0007399; P:nervous system development; TAS:UniProtKB.
DR GO; GO:2001222; P:regulation of neuron migration; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; IEA:Ensembl.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR029549; SOX-14.
DR InterPro; IPR022097; SOX_fam.
DR PANTHER; PTHR10270:SF107; PTHR10270:SF107; 1.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12336; SOXp; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 1: Evidence at protein level;
KW DNA-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..240
FT /note="Transcription factor SOX-14"
FT /id="PRO_0000048758"
FT DNA_BIND 8..76
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
SQ SEQUENCE 240 AA; 26485 MW; 7F574AFDA571D903 CRC64;
MSKPSDHIKR PMNAFMVWSR GQRRKMAQEN PKMHNSEISK RLGAEWKLLS EAEKRPYIDE
AKRLRAQHMK EHPDYKYRPR RKPKNLLKKD RYVFPLPYLG DTDPLKAAGL PVGASDGLLS
APEKARAFLP PASAPYSLLD PAQFSSSAIQ KMGEVPHTLA TGALPYASTL GYQNGAFGSL
SCPSQHTHTH PSPTNPGYVV PCNCTAWSAS TLQPPVAYIL FPGMTKTGID PYSSAHATAM
