ID   SOX14_MACFA             Reviewed;         240 AA.
AC   P61259;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2004, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Transcription factor SOX-14;
GN   Name=SOX14; ORFNames=QtrA-14282;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Temporal cortex;
RA   Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA   Suzuki Y., Sugano S., Hashimoto K.;
RT   "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL   Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a negative regulator of transcription. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
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DR   EMBL; AB063098; BAB60804.1; -; mRNA.
DR   RefSeq; NP_001274648.1; NM_001287719.1.
DR   AlphaFoldDB; P61259; -.
DR   SMR; P61259; -.
DR   STRING; 9541.XP_005545919.1; -.
DR   Ensembl; ENSMFAT00000063486; ENSMFAP00000013535; ENSMFAG00000029238.
DR   GeneID; 102124781; -.
DR   CTD; 8403; -.
DR   VEuPathDB; HostDB:ENSMFAG00000029238; -.
DR   eggNOG; KOG0527; Eukaryota.
DR   GeneTree; ENSGT00940000160749; -.
DR   OMA; NCTAWST; -.
DR   OrthoDB; 1335452at2759; -.
DR   Proteomes; UP000233100; Chromosome 2.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005667; C:transcription regulator complex; IEA:Ensembl.
DR   GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:Ensembl.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:1990837; F:sequence-specific double-stranded DNA binding; IEA:Ensembl.
DR   GO; GO:0009649; P:entrainment of circadian clock; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:2001222; P:regulation of neuron migration; IEA:Ensembl.
DR   GO; GO:0007601; P:visual perception; IEA:Ensembl.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR029549; SOX-14.
DR   InterPro; IPR022097; SOX_fam.
DR   PANTHER; PTHR10270:SF107; PTHR10270:SF107; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   Pfam; PF12336; SOXp; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..240
FT                   /note="Transcription factor SOX-14"
FT                   /id="PRO_0000048759"
FT   DNA_BIND        8..76
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
SQ   SEQUENCE   240 AA;  26485 MW;  7F574AFDA571D903 CRC64;
     MSKPSDHIKR PMNAFMVWSR GQRRKMAQEN PKMHNSEISK RLGAEWKLLS EAEKRPYIDE
     AKRLRAQHMK EHPDYKYRPR RKPKNLLKKD RYVFPLPYLG DTDPLKAAGL PVGASDGLLS
     APEKARAFLP PASAPYSLLD PAQFSSSAIQ KMGEVPHTLA TGALPYASTL GYQNGAFGSL
     SCPSQHTHTH PSPTNPGYVV PCNCTAWSAS TLQPPVAYIL FPGMTKTGID PYSSAHATAM