SOX14_MOUSE
ID SOX14_MOUSE Reviewed; 240 AA.
AC Q04892; Q9JLC9; Q9JLD0; Q9QXU4;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 14-AUG-2001, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Transcription factor SOX-14;
GN Name=Sox14; Synonyms=Sox-14;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=129/Sv;
RX PubMed=10677261; DOI=10.1006/dbio.1999.9581;
RA Hargrave M., Karunaratne A., Cox L., Wood S., Koopman P., Yamada T.;
RT "The HMG box transcription factor gene Sox14 marks a novel subset of
RT ventral interneurons and is regulated by sonic hedgehog.";
RL Dev. Biol. 219:142-153(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-229.
RX PubMed=10798354; DOI=10.1007/s004390051037;
RA Wilmore H.P., Smith M.J., Wilcox S.A., Bell K.M., Sinclair A.H.;
RT "SOX14 is a candidate gene for limb defects associated with BPES and Mobius
RT syndrome.";
RL Hum. Genet. 106:269-276(2000).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 16-71.
RX PubMed=8441686; DOI=10.1093/nar/21.3.744;
RA Wright E.M., Snopek B., Koopman P.;
RT "Seven new members of the Sox gene family expressed during mouse
RT development.";
RL Nucleic Acids Res. 21:744-744(1993).
CC -!- FUNCTION: Acts as a negative regulator of transcription. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC -!- TISSUE SPECIFICITY: Highly expressed in developing brain and spinal
CC cord. {ECO:0000269|PubMed:10677261}.
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DR EMBL; AF193437; AAF62397.1; -; Genomic_DNA.
DR EMBL; AF193435; AAF62396.1; -; mRNA.
DR EMBL; AF182357; AAF19353.1; -; Genomic_DNA.
DR EMBL; Z18963; CAA79488.1; -; mRNA.
DR CCDS; CCDS57695.1; -.
DR PIR; S30244; S30244.
DR RefSeq; NP_035570.1; NM_011440.1.
DR AlphaFoldDB; Q04892; -.
DR SMR; Q04892; -.
DR BioGRID; 203401; 1.
DR STRING; 10090.ENSMUSP00000091310; -.
DR iPTMnet; Q04892; -.
DR PhosphoSitePlus; Q04892; -.
DR PaxDb; Q04892; -.
DR PeptideAtlas; Q04892; -.
DR PRIDE; Q04892; -.
DR Antibodypedia; 17867; 155 antibodies from 25 providers.
DR Ensembl; ENSMUST00000054819; ENSMUSP00000091310; ENSMUSG00000053747.
DR GeneID; 20669; -.
DR KEGG; mmu:20669; -.
DR UCSC; uc012gzb.1; mouse.
DR CTD; 8403; -.
DR MGI; MGI:98362; Sox14.
DR VEuPathDB; HostDB:ENSMUSG00000053747; -.
DR eggNOG; KOG0527; Eukaryota.
DR GeneTree; ENSGT00940000160749; -.
DR InParanoid; Q04892; -.
DR OMA; NCTAWST; -.
DR OrthoDB; 1335452at2759; -.
DR PhylomeDB; Q04892; -.
DR TreeFam; TF351735; -.
DR BioGRID-ORCS; 20669; 1 hit in 73 CRISPR screens.
DR ChiTaRS; Sox14; mouse.
DR PRO; PR:Q04892; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q04892; protein.
DR Bgee; ENSMUSG00000053747; Expressed in urethra and 42 other tissues.
DR ExpressionAtlas; Q04892; baseline and differential.
DR Genevisible; Q04892; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IDA:MGI.
DR GO; GO:0003682; F:chromatin binding; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IDA:MGI.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0009649; P:entrainment of circadian clock; IMP:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:2001222; P:regulation of neuron migration; IMP:MGI.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0007601; P:visual perception; IMP:MGI.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR029549; SOX-14.
DR InterPro; IPR022097; SOX_fam.
DR PANTHER; PTHR10270:SF107; PTHR10270:SF107; 1.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12336; SOXp; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..240
FT /note="Transcription factor SOX-14"
FT /id="PRO_0000048760"
FT DNA_BIND 8..76
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
SQ SEQUENCE 240 AA; 26515 MW; 158D8AE76571C856 CRC64;
MSKPSDHIKR PMNAFMVWSR GQRRKMAQEN PKMHNSEISK RLGAEWKLLS EAEKRPYIDE
AKRLRAQHMK EHPDYKYRPR RKPKNLLKKD RYVFPLPYLG DTDPLKAAGL PVGASDGLLS
APEKARAFLP PASAPYSLLD PAQFSSSAIQ KMGEVPHTLA TSALPYASTL GYQNGAFGSL
SCPSQHTHTH PSPTNPGYVV PCNCTAWSAS TLQPPVAYIL FPGMTKTGID PYSSAHATAM
