ID   SOX14_XENLA             Reviewed;         239 AA.
AC   B0ZTE2;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Transcription factor Sox-14 {ECO:0000250|UniProtKB:Q9W7R6};
DE   AltName: Full=SRY (sex determining region Y)-box 14;
GN   Name=sox14 {ECO:0000312|EMBL:ABY90181.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:ABY90181.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], PUTATIVE FUNCTION, TISSUE SPECIFICITY,
RP   AND DEVELOPMENTAL STAGE.
RX   PubMed=18956331; DOI=10.1387/ijdb.082586dc;
RA   Cunningham D.D., Meng Z., Fritzsch B., Casey E.S.;
RT   "Cloning and developmental expression of the soxB2 genes, sox14 and sox21,
RT   during Xenopus laevis embryogenesis.";
RL   Int. J. Dev. Biol. 52:999-1004(2008).
CC   -!- FUNCTION: Acts as a negative regulator of transcription (By
CC       similarity). May function as a switch in neuronal development.
CC       {ECO:0000250|UniProtKB:Q9W7R6, ECO:0000269|PubMed:18956331}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9W7R6,
CC       ECO:0000255|PROSITE-ProRule:PRU00267}.
CC   -!- TISSUE SPECIFICITY: In the developing embryo, restricted to the
CC       hypothalamus, dorsal thalamus, optic tectum, a region of the somatic
CC       motornucleus in the midbrain and hindbrain, the vestibular nuclei in
CC       the hindbrain, and a discrete ventral domain in the developing spinal
CC       cord. {ECO:0000269|PubMed:18956331}.
CC   -!- DEVELOPMENTAL STAGE: First expressed at stage 25. Expression peaks at
CC       stage 28 and continues at this level throughout all later stages, until
CC       at least stage 38. {ECO:0000269|PubMed:18956331}.
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DR   EMBL; EU403425; ABY90181.1; -; Genomic_DNA.
DR   RefSeq; NP_001165685.1; NM_001172214.1.
DR   AlphaFoldDB; B0ZTE2; -.
DR   SMR; B0ZTE2; -.
DR   MaxQB; B0ZTE2; -.
DR   GeneID; 100337614; -.
DR   KEGG; xla:100337614; -.
DR   CTD; 100337614; -.
DR   Xenbase; XB-GENE-6458188; sox14.S.
DR   OMA; SAHAPAM; -.
DR   OrthoDB; 1335452at2759; -.
DR   Proteomes; UP000186698; Chromosome 5S.
DR   Bgee; 100337614; Expressed in brain and 1 other tissue.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0007399; P:nervous system development; IEP:UniProtKB.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR029549; SOX-14.
DR   InterPro; IPR022097; SOX_fam.
DR   PANTHER; PTHR10270:SF107; PTHR10270:SF107; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   Pfam; PF12336; SOXp; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..239
FT                   /note="Transcription factor Sox-14"
FT                   /id="PRO_0000378069"
FT   DNA_BIND        8..76
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
SQ   SEQUENCE   239 AA;  26865 MW;  DE32D616AD01C977 CRC64;
     MSKPVDHIKR PMNAFMVWSR GQRRKMAQEN PKMHNSEISK RLGAEWKLLS EAEKRPYIDE
     AKRLRAQHMK EHPDYKYRPR RKPKNLLKKD RYVFPLPYFG DHDPLKTGLS MSATDSILGA
     SEKARAFFPP TSTPYSLLDP SHFSSTTIQK MTEMPHTLAT STLPYASTLG YQNGAFGGLS
     CPSQHTHTHP SPTNPGYVVP CNCTAWSASN LQPPVAYILF PGMTKAGIDP YSSAHTTAM