ID   SOX14_XENTR             Reviewed;         239 AA.
AC   A4QNG3;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   15-MAY-2007, sequence version 1.
DT   03-AUG-2022, entry version 88.
DE   RecName: Full=Transcription factor Sox-14 {ECO:0000250|UniProtKB:Q9W7R6};
DE   AltName: Full=SRY (sex determining region Y)-box 14;
GN   Name=sox14 {ECO:0000312|EMBL:AAI35638.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:CAP58280.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Tadpole {ECO:0000312|EMBL:CAP58280.1};
RA   Grammer T., Harland R.;
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:CAP58280.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tadpole {ECO:0000312|EMBL:CAP58280.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as a negative regulator of transcription. May function
CC       as a switch in neuronal development (By similarity).
CC       {ECO:0000250|UniProtKB:B0ZTE2, ECO:0000250|UniProtKB:Q9W7R6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9W7R6,
CC       ECO:0000255|PROSITE-ProRule:PRU00267}.
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DR   EMBL; AM922298; CAP58280.1; -; mRNA.
DR   EMBL; BC135637; AAI35638.1; -; mRNA.
DR   RefSeq; NP_001093703.1; NM_001100233.1.
DR   AlphaFoldDB; A4QNG3; -.
DR   SMR; A4QNG3; -.
DR   PaxDb; A4QNG3; -.
DR   DNASU; 100101715; -.
DR   Ensembl; ENSXETT00000078008; ENSXETP00000085756; ENSXETG00000034566.
DR   GeneID; 100101715; -.
DR   KEGG; xtr:100101715; -.
DR   CTD; 8403; -.
DR   Xenbase; XB-GENE-485370; sox14.
DR   eggNOG; KOG0527; Eukaryota.
DR   HOGENOM; CLU_021123_3_1_1; -.
DR   InParanoid; A4QNG3; -.
DR   OMA; NCTAWST; -.
DR   OrthoDB; 1335452at2759; -.
DR   PhylomeDB; A4QNG3; -.
DR   TreeFam; TF351735; -.
DR   Reactome; R-XTR-3769402; Deactivation of the beta-catenin transactivating complex.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000034566; Expressed in brain and 1 other tissue.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0007399; P:nervous system development; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR029549; SOX-14.
DR   InterPro; IPR022097; SOX_fam.
DR   PANTHER; PTHR10270:SF107; PTHR10270:SF107; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   Pfam; PF12336; SOXp; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..239
FT                   /note="Transcription factor Sox-14"
FT                   /id="PRO_0000378070"
FT   DNA_BIND        8..76
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
SQ   SEQUENCE   239 AA;  26684 MW;  C299403B88894CF9 CRC64;
     MSKPVDHIKR PMNAFMVWSR GQRRKMAQEN PKMHNSEISK RLGAEWKLLS EAEKRPYIDE
     AKRLRAQHMK EHPDYKYRPR RKPKNLLKKD RYVFPLPYLG DHDPLKTGLS MSATDSLLGA
     SEKARAFLPP TSAPYSLLDP SQFSSTTIQK MTEMPHTLAA STLPYASTLG YQNGAFGGLS
     CPSQHTHTHP SPTNPGYVVP CNCSAWSASN LQPPVAYILF PGMTKAGLDP YSSAHTAAM