SOX15_DROME
ID SOX15_DROME Reviewed; 784 AA.
AC P40657; Q1LZ22; Q4V734; Q9U1J5; Q9V6Y8;
DT 01-FEB-1995, integrated into UniProtKB/Swiss-Prot.
DT 21-FEB-2001, sequence version 2.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Putative transcription factor SOX-15;
DE AltName: Full=Sox50E;
GN Name=Sox15; Synonyms=SOX50E; ORFNames=CG8404;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Canton-S; TISSUE=Larva;
RA Loh S.H.Y., Whitworth A., Russell S.;
RT "Sox50E, a Drosophila Sox domain gene expressed in the proximal region of
RT the wing imaginal disc.";
RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley;
RA Stapleton M., Carlson J.W., Chavez C., Frise E., George R.A., Kapadia B.,
RA Pacleb J.M., Park S., Wan K.H., Yu C., Celniker S.E.;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 226-279.
RC STRAIN=Canton-S;
RX PubMed=1614875; DOI=10.1093/nar/20.11.2887;
RA Denny P., Swift S., Brand N., Dabhade N., Barton P., Ashworth A.;
RT "A conserved family of genes related to the testis determining gene, SRY.";
RL Nucleic Acids Res. 20:2887-2887(1992).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB63944.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AJ250955; CAB63944.1; ALT_FRAME; mRNA.
DR EMBL; AE013599; AAF58279.2; -; Genomic_DNA.
DR EMBL; BT022122; AAY51517.1; -; mRNA.
DR EMBL; BT025204; ABF17895.1; -; mRNA.
DR EMBL; X65668; CAA46619.1; -; mRNA.
DR PIR; S22936; S22936.
DR RefSeq; NP_523739.2; NM_079015.3.
DR AlphaFoldDB; P40657; -.
DR SMR; P40657; -.
DR BioGRID; 62325; 7.
DR DIP; DIP-21090N; -.
DR IntAct; P40657; 2.
DR STRING; 7227.FBpp0086702; -.
DR PaxDb; P40657; -.
DR EnsemblMetazoa; FBtr0087576; FBpp0086702; FBgn0005613.
DR GeneID; 36575; -.
DR KEGG; dme:Dmel_CG8404; -.
DR CTD; 6665; -.
DR FlyBase; FBgn0005613; Sox15.
DR VEuPathDB; VectorBase:FBgn0005613; -.
DR eggNOG; KOG0527; Eukaryota.
DR GeneTree; ENSGT00940000168435; -.
DR HOGENOM; CLU_017979_0_0_1; -.
DR InParanoid; P40657; -.
DR OMA; YDHEHPH; -.
DR OrthoDB; 498719at2759; -.
DR PhylomeDB; P40657; -.
DR Reactome; R-DME-3769402; Deactivation of the beta-catenin transactivating complex.
DR SignaLink; P40657; -.
DR BioGRID-ORCS; 36575; 0 hits in 3 CRISPR screens.
DR GenomeRNAi; 36575; -.
DR PRO; PR:P40657; -.
DR Proteomes; UP000000803; Chromosome 2R.
DR Bgee; FBgn0005613; Expressed in antenna and 24 other tissues.
DR Genevisible; P40657; DM.
DR GO; GO:0005634; C:nucleus; IDA:FlyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0022416; P:chaeta development; IMP:FlyBase.
DR GO; GO:0043066; P:negative regulation of apoptotic process; IMP:FlyBase.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IMP:FlyBase.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IGI:FlyBase.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:FlyBase.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0035220; P:wing disc development; IMP:FlyBase.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..784
FT /note="Putative transcription factor SOX-15"
FT /id="PRO_0000048804"
FT DNA_BIND 215..283
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 278..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 407..448
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 686..719
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 301..356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..437
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 12
FT /note="H -> R (in Ref. 1; CAB63944)"
FT /evidence="ECO:0000305"
FT CONFLICT 320
FT /note="P -> L (in Ref. 4; AAY51517)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 784 AA; 84872 MW; BEA3BF3FF25DC9AC CRC64;
MEPSYDHEHP HHLLTNYNSK KYPHVSRTPE YSHSTGSDYP EHGGYLTDGR LMHESNSDAG
IYHVRQGSEH SSPSLHSPAI QSSGYENEHL NEAVLAAHSH SHSPMPMVSS AYVGGGTASG
SLINSNIPLL GGGGNSVLNK FLSHPHAGMV GGGTGQMEDC TSHSPIEAAS MWSYDYKGDL
CAPNCGYLER HKPLPADLKY RPGGTQSKSA KESRIRRPMN AFMVWAKIER KKLADENPDL
HNADLSKMLG KKWRSLTPQD RRPYVEEAER LRVIHMTEHP NYKYRPRRRK QSKLRAMQPG
GKEQSESSPN PGTGGSKSNP KLATPPLATA SSSYTTPTDE STCNSTNQNH GQSTPGGLYE
QPLKPTYSPS SVDCYSNADS TEQIESLAAN CPPALLNESS PTGGGYDNSL LLKKLTKPSP
SRAAKSRQEK LAKSEEKNKG SQSQGQSQQG IYAATYPLAP TSVAVVAARG MYVTCNNRGL
LDHGHSVKGT FYPPVSVSED DNSTSMRNSI SALQQHCNVV TSTPSSSGGT MPTSEMSSYT
VSMADNCGNL RLSMNELSGN EYLPSANAYG MQYEDFLRYQ SNDMDYSTSA VEHKETTSDS
ASGQKCLKYP DTNQNYDDYE AEAYSNAMLP ATAASYYTQL PYPPTSLAAF PLQLAVPFQQ
TTSGAYGAQP IQSGYLHYGN YGGYEGMAQS QPQNQAPVHH QQASHSAPPS LSVPPNQTVT
SNSAAISMQQ HHHHHFGPAP GMVGVGVGVG VGVGVGEMLF EQQQRKDDEI SNILAGVRKT
CYSN
