ID   SOX18_XENTR             Reviewed;         362 AA.
AC   B3DLD3;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   22-JUL-2008, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Transcription factor Sox-18 {ECO:0000250|UniProtKB:P43680};
DE   AltName: Full=SRY (sex determining region Y)-box 18;
GN   Name=sox18 {ECO:0000312|EMBL:AAI67402.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:AAI67402.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6 {ECO:0000312|EMBL:AAI67402.1};
RC   TISSUE=Fat body {ECO:0000312|EMBL:AAI67402.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcription factor. Binds to the consensus DNA sequence 5'-
CC       AACAAT-3'. Also binds 5'-CACAAT-3' and 5'-AATAAT-3' but with a lower
CC       affinity. Acts partially redundantly with sox7 during cardiogenesis,
CC       acting indirectly through nodal-signaling to induce mesodermal,
CC       organizer and endodermal tissues, which then interact to initiate
CC       cardiogenesis. Also acts as an antagonist of beta-catenin signaling (By
CC       similarity). {ECO:0000250|UniProtKB:Q90ZH7}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC   -!- DOMAIN: Binds target DNA via the HMG box domain.
CC       {ECO:0000250|UniProtKB:P43680}.
CC   -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC       number of yeast and animal transcription factors.
CC       {ECO:0000250|UniProtKB:P35713}.
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DR   EMBL; BC167402; AAI67402.1; -; mRNA.
DR   RefSeq; NP_001123409.1; NM_001129937.1.
DR   AlphaFoldDB; B3DLD3; -.
DR   SMR; B3DLD3; -.
DR   GeneID; 100170185; -.
DR   KEGG; xtr:100170185; -.
DR   CTD; 54345; -.
DR   Xenbase; XB-GENE-483233; sox18.
DR   InParanoid; B3DLD3; -.
DR   OrthoDB; 1042753at2759; -.
DR   Proteomes; UP000008143; Chromosome 10.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0001525; P:angiogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0007507; P:heart development; ISS:UniProtKB.
DR   GO; GO:0001946; P:lymphangiogenesis; IBA:GO_Central.
DR   GO; GO:0030178; P:negative regulation of Wnt signaling pathway; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0001570; P:vasculogenesis; IBA:GO_Central.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR033392; Sox7/17/18_central.
DR   InterPro; IPR021934; Sox_C.
DR   Pfam; PF00505; HMG_box; 1.
DR   Pfam; PF12067; Sox17_18_mid; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
DR   PROSITE; PS51516; SOX_C; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..362
FT                   /note="Transcription factor Sox-18"
FT                   /id="PRO_0000375980"
FT   DOMAIN          235..361
FT                   /note="Sox C-terminal"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00849"
FT   DNA_BIND        68..136
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          1..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          70..83
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250|UniProtKB:P43680"
FT   REGION          94..106
FT                   /note="Interaction with DNA"
FT                   /evidence="ECO:0000250|UniProtKB:P43680"
FT   REGION          129..159
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          149..209
FT                   /note="Important for transcriptional activation"
FT                   /evidence="ECO:0000250|UniProtKB:P43680"
FT   MOTIF           307..315
FT                   /note="9aaTAD"
FT                   /evidence="ECO:0000250|UniProtKB:P35713"
FT   COMPBIAS        14..29
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        30..53
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   362 AA;  40280 MW;  BFCDDE20CC9FFA0B CRC64;
     MHRPEPSYCR EEPTPCQGVN STWVPPADTV PETSPTPSSP PAPDSPTPSP QPGYGYSPCE
     EKPGDPRIRR PMNAFMVWAK DERKRLAQQN PDLHNAVLSK MLGQSWKNLS SAEKRPFVEE
     AERLRVQHLQ DHPNYKYRPR RKKQAKKLKR VDPSPLLRNE GYRGQAMANL SHFRDLHPLG
     GSGDLESYGL PTPEMSPLDV VEPSEPAFFP PHMREEADPG PFRTYQHGVD FGQEKTLREI
     SLPYSSSPSH MGGFLRTPTA SAFYYNPHGG SPACTPLGQL SPPPEAPALE AMDHLGPAEL
     WGDFDRNEFD QYLNMSRTQG PGYPFPMSKL GAPRTIPCEE SSLISALSDA STAMYYTPCI
     TG