SOX1_CHICK
ID SOX1_CHICK Reviewed; 373 AA.
AC O57401;
DT 27-JUL-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Transcription factor SOX-1;
GN Name=SOX1;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RX PubMed=9609835; DOI=10.1242/dev.125.13.2521;
RA Kamachi Y., Uchikawa M., Collignon J., Lovell-Badge R., Kondoh H.;
RT "Involvement of Sox1, 2 and 3 in the early and subsequent molecular events
RT of lens induction.";
RL Development 125:2521-2532(1998).
RN [2]
RP FUNCTION.
RX PubMed=14517545; DOI=10.1038/nn1131;
RA Bylund M., Andersson E., Novitch B.G., Muhr J.;
RT "Vertebrate neurogenesis is counteracted by Sox1-3 activity.";
RL Nat. Neurosci. 6:1162-1168(2003).
CC -!- FUNCTION: Transcriptional activator. May function as a switch in
CC neuronal development. Keeps neural cells undifferentiated by
CC counteracting the activity of proneural protein and suppresses neuronal
CC differentiation. {ECO:0000269|PubMed:14517545,
CC ECO:0000269|PubMed:9609835}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC number of yeast and animal transcription factors.
CC {ECO:0000250|UniProtKB:P41225}.
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DR EMBL; AB011802; BAA25092.1; -; mRNA.
DR RefSeq; NP_989664.1; NM_204333.1.
DR AlphaFoldDB; O57401; -.
DR SMR; O57401; -.
DR GeneID; 374240; -.
DR KEGG; gga:374240; -.
DR CTD; 6656; -.
DR VEuPathDB; HostDB:geneid_374240; -.
DR InParanoid; O57401; -.
DR OrthoDB; 1161594at2759; -.
DR PhylomeDB; O57401; -.
DR PRO; PR:O57401; -.
DR Proteomes; UP000000539; Unplaced.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IEA:InterPro.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR031268; SOX-1.
DR InterPro; IPR022097; SOX_fam.
DR PANTHER; PTHR10270:SF40; PTHR10270:SF40; 1.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12336; SOXp; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..373
FT /note="Transcription factor SOX-1"
FT /id="PRO_0000411020"
FT DNA_BIND 48..116
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 211..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 327..335
FT /note="9aaTAD"
FT /evidence="ECO:0000250|UniProtKB:P41225"
FT COMPBIAS 220..234
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 373 AA; 37935 MW; 9B81BDCBED211DA3 CRC64;
MYSMMMETDL HSPGGAPAPG GGLSGQSGAG GGGGGGGGGG GKAGQDRVKR PMNAFMVWSR
GQRRKMAQEN PKMHNSEISK RLGAEWKVMS EAEKRPFIDE AKRLRALHMK EHPDYKYRPR
RKTKTLLKKD KYSLAGGLLG AGPAAGGPPA VGVGMGVGVI PGGVGQRLES PGGAAGGGYA
HMNGWANGAY PGSVAAAAAA AAMMQEAQLA YGQHPGGGGH PHHPHPHHPH HPHNPQPMHR
YDMGALQYSP ISNSQGYVSA SPSGYGALPY GSQPHQNSAA AAAAAAAAAA ASSGALGALG
SLVKSEPSVS PPVTSHSRAP CPGDLREMIS MYLPGGEGGD PAAAAAQSRL HSLPQHYQSA
STGVNGTVPL THI
