SOX1_MOUSE
ID SOX1_MOUSE Reviewed; 391 AA.
AC P53783; Q80XF2;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 16-OCT-2013, sequence version 2.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Transcription factor SOX-1;
GN Name=Sox1; Synonyms=Sox-1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129;
RX PubMed=8625802; DOI=10.1242/dev.122.2.509;
RA Collignon J., Sockanathan S., Hacker A., Cohen-Tannoudji M., Norris D.,
RA Rastan S., Stevanovic M., Goodfellow P.N., Lovell-Badge R.;
RT "A comparison of the properties of Sox-3 with Sry and two related genes,
RT Sox-1 and Sox-2.";
RL Development 122:509-520(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=129/Ola;
RX PubMed=15456859; DOI=10.1128/mcb.24.20.8834-8846.2004;
RA Tanaka S., Kamachi Y., Tanouchi A., Hamada H., Jing N., Kondoh H.;
RT "Interplay of SOX and POU factors in regulation of the nestin gene in
RT neural primordial cells.";
RL Mol. Cell. Biol. 24:8834-8846(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- FUNCTION: Transcriptional activator. May function as a switch in
CC neuronal development. Keeps neural cells undifferentiated by
CC counteracting the activity of proneural proteins and suppresses
CC neuronal differentiation (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Mainly in the developing central nervous system.
CC Expressed in developing urogenital ridge.
CC -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC number of yeast and animal transcription factors.
CC {ECO:0000250|UniProtKB:P41225}.
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DR EMBL; X94126; CAA63846.1; -; Genomic_DNA.
DR EMBL; AB108672; BAC75667.1; -; mRNA.
DR EMBL; AC102525; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS57605.1; -.
DR PIR; S10950; S10950.
DR RefSeq; NP_033259.2; NM_009233.3.
DR AlphaFoldDB; P53783; -.
DR SMR; P53783; -.
DR BioGRID; 203396; 1.
DR STRING; 10090.ENSMUSP00000137203; -.
DR iPTMnet; P53783; -.
DR PhosphoSitePlus; P53783; -.
DR PaxDb; P53783; -.
DR PeptideAtlas; P53783; -.
DR PRIDE; P53783; -.
DR ProteomicsDB; 257285; -.
DR Antibodypedia; 25675; 315 antibodies from 36 providers.
DR DNASU; 20664; -.
DR Ensembl; ENSMUST00000180353; ENSMUSP00000137203; ENSMUSG00000096014.
DR GeneID; 20664; -.
DR KEGG; mmu:20664; -.
DR UCSC; uc009kwa.2; mouse.
DR CTD; 6656; -.
DR MGI; MGI:98357; Sox1.
DR VEuPathDB; HostDB:ENSMUSG00000096014; -.
DR eggNOG; KOG0527; Eukaryota.
DR GeneTree; ENSGT00940000162479; -.
DR HOGENOM; CLU_021123_0_0_1; -.
DR InParanoid; P53783; -.
DR OMA; GPKANQD; -.
DR OrthoDB; 1161594at2759; -.
DR PhylomeDB; P53783; -.
DR TreeFam; TF351735; -.
DR BioGRID-ORCS; 20664; 0 hits in 72 CRISPR screens.
DR PRO; PR:P53783; -.
DR Proteomes; UP000000589; Chromosome 8.
DR RNAct; P53783; protein.
DR Bgee; ENSMUSG00000096014; Expressed in medial ganglionic eminence and 84 other tissues.
DR Genevisible; P53783; MM.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0003677; F:DNA binding; IDA:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:1990830; P:cellular response to leukemia inhibitory factor; IDA:MGI.
DR GO; GO:0030900; P:forebrain development; IMP:MGI.
DR GO; GO:0021884; P:forebrain neuron development; IMP:MGI.
DR GO; GO:0021879; P:forebrain neuron differentiation; IMP:MGI.
DR GO; GO:1904936; P:interneuron migration; IMP:UniProtKB.
DR GO; GO:0002089; P:lens morphogenesis in camera-type eye; IMP:MGI.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR GO; GO:0001764; P:neuron migration; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0048713; P:regulation of oligodendrocyte differentiation; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0021521; P:ventral spinal cord interneuron specification; IMP:MGI.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR031268; SOX-1.
DR InterPro; IPR022097; SOX_fam.
DR PANTHER; PTHR10270:SF40; PTHR10270:SF40; 1.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12336; SOXp; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..391
FT /note="Transcription factor SOX-1"
FT /id="PRO_0000048713"
FT DNA_BIND 51..119
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 214..249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 342..350
FT /note="9aaTAD"
FT /evidence="ECO:0000250|UniProtKB:P41225"
FT COMPBIAS 227..242
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 29
FT /note="G -> R (in Ref. 1; CAA63846)"
FT /evidence="ECO:0000305"
FT CONFLICT 222
FT /note="A -> R (in Ref. 1; CAA63846)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 391 AA; 39053 MW; EA88F7C49E30BDA8 CRC64;
MYSMMMETDL HSPGGAQAPT NLSGPAGAGG GGGGGGGGGG GGGTKANQDR VKRPMNAFMV
WSRGQRRKMA QENPKMHNSE ISKRLGAEWK VMSEAEKRPF IDEAKRLRAL HMKEHPDYKY
RPRRKTKTLL KKDKYSLAGG LLAAGAGGGG AAVAMGVGVG VGAAAVGQRL ESPGGAAGGG
YAHVNGWANG AYPGSVAAAA AAAAMMQEAQ LAYGQHPGAG GAHPHAHPAH PHPHHPHAHP
HNPQPMHRYD MGALQYSPIS NSQGYMSASP SGYGGIPYGA AAAAAAAAGG AHQNSAVAAA
AAAAAASSGA LGALGSLVKS EPSGSPPAPA HSRAPCPGDL REMISMYLPA GEGGDPAAAA
AAAAQSRLHS LPQHYQGAGA GVNGTVPLTH I
