ID   SOX1_XENTR              Reviewed;         401 AA.
AC   A2TED3; Q0D2F2;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   06-MAR-2007, sequence version 1.
DT   03-AUG-2022, entry version 77.
DE   RecName: Full=Transcription factor Sox-1 {ECO:0000250|UniProtKB:Q6DGL6};
DE   AltName: Full=SRY (Sex determining region Y)-box 1 {ECO:0000312|EMBL:AAI59122.1};
GN   Name=sox1 {ECO:0000312|EMBL:AAI21847.1};
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:ABM92339.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Zhang C., Grammer T.C., Basta T., Tai P., Espinosa J.M., Klymkowsky M.W.;
RT   "Sox3 acts through multiple regulatory targets to suppress Nodal signaling
RT   during Xenopus germ-layer specification.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:ABM92339.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain {ECO:0000312|EMBL:AAI59122.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional activator. Participates in neural induction
CC       (By similarity). {ECO:0000250|UniProtKB:Q2PG84,
CC       ECO:0000250|UniProtKB:Q6DGL6}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P48430,
CC       ECO:0000255|PROSITE-ProRule:PRU00267}.
CC   -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC       number of yeast and animal transcription factors.
CC       {ECO:0000250|UniProtKB:P41225}.
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DR   EMBL; EF192052; ABM92339.1; -; mRNA.
DR   EMBL; BC121846; AAI21847.1; -; mRNA.
DR   EMBL; BC159121; AAI59122.1; -; mRNA.
DR   RefSeq; NP_001074465.1; NM_001080996.1.
DR   AlphaFoldDB; A2TED3; -.
DR   SMR; A2TED3; -.
DR   GeneID; 779569; -.
DR   KEGG; xtr:779569; -.
DR   CTD; 6656; -.
DR   Xenbase; XB-GENE-1018269; sox1.
DR   InParanoid; A2TED3; -.
DR   OrthoDB; 1161594at2759; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; ISS:UniProtKB.
DR   GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR031268; SOX-1.
DR   InterPro; IPR022097; SOX_fam.
DR   PANTHER; PTHR10270:SF40; PTHR10270:SF40; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   Pfam; PF12336; SOXp; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..401
FT                   /note="Transcription factor Sox-1"
FT                   /id="PRO_0000378064"
FT   DNA_BIND        37..105
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          1..38
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          197..249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          320..343
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           345..353
FT                   /note="9aaTAD"
FT                   /evidence="ECO:0000250|UniProtKB:P41225"
FT   COMPBIAS        13..30
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        211..234
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   401 AA;  41493 MW;  EF0E6F5D4C029EF2 CRC64;
     MYSMMMETDL HSPGVQPPSN TGQTGGGGGN KANQDRVKRP MNAFMVWSRG QRRKMAQENP
     KMHNSEISKR LGAEWKVMSE AEKRPFIDEA KRLRALHMKE HPDYKYRPRR KTKTLLKKDK
     YSLAGGLLHA AGGGHMGVGL SPGGGGGGTG GVVVQRLESP GSGASAGGYA HMNGWANGAY
     PGSVAAAAAA AMMQEAQLAY SQQQQQHPGS GGHHPHHHPH HPHHHPHHHP HHNPTPHPPP
     PPPQPMHRYD MSALQYSPLP GAQTYMTASP SGYGALGYSS SQQQHQGSPS SAAVAAAAAA
     AAAAAASSGA LGALGSLVKS EPSVSPPVSG GGPHNRPPCP GDLREMISMY LPSGGEAGDP
     AAAAAAAAAA AAAATSRLHS LPQHYQGAGT GVTGTVPLTH I