SOX21_CHICK
ID SOX21_CHICK Reviewed; 280 AA.
AC Q9W7R5;
DT 15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Transcription factor SOX-21;
GN Name=SOX21;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND TISSUE SPECIFICITY.
RC TISSUE=Liver;
RX PubMed=10473124; DOI=10.1016/s0925-4773(99)00083-0;
RA Uchikawa M., Kamachi Y., Kondoh H.;
RT "Two distinct subgroups of Group B Sox genes for transcriptional activators
RT and repressors: their expression during embryonic organogenesis of the
RT chicken.";
RL Mech. Dev. 84:103-120(1999).
CC -!- FUNCTION: Acts as a negative regulator of transcription.
CC {ECO:0000269|PubMed:10473124}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed predominantly in CNS.
CC {ECO:0000269|PubMed:10473124}.
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DR EMBL; AB026623; BAA77266.1; -; Genomic_DNA.
DR RefSeq; XP_015130211.1; XM_015274725.1.
DR AlphaFoldDB; Q9W7R5; -.
DR SMR; Q9W7R5; -.
DR Ensembl; ENSGALT00000053144; ENSGALP00000049013; ENSGALG00000035157.
DR GeneID; 107051027; -.
DR KEGG; gga:107051027; -.
DR CTD; 11166; -.
DR VEuPathDB; HostDB:geneid_107051027; -.
DR GeneTree; ENSGT00940000162795; -.
DR InParanoid; Q9W7R5; -.
DR OMA; SDSIMGH; -.
DR OrthoDB; 1335452at2759; -.
DR PhylomeDB; Q9W7R5; -.
DR PRO; PR:Q9W7R5; -.
DR Proteomes; UP000000539; Chromosome 1.
DR Bgee; ENSGALG00000035157; Expressed in brain and 6 other tissues.
DR GO; GO:0005634; C:nucleus; IC:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:Ensembl.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0048839; P:inner ear development; IMP:CACAO.
DR GO; GO:0042472; P:inner ear morphogenesis; IMP:AgBase.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IDA:UniProtKB.
DR GO; GO:0045595; P:regulation of cell differentiation; IMP:AgBase.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR GO; GO:0043588; P:skin development; IEA:Ensembl.
DR GO; GO:0048863; P:stem cell differentiation; IEA:Ensembl.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR022097; SOX_fam.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12336; SOXp; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW DNA-binding; Nucleus; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..280
FT /note="Transcription factor SOX-21"
FT /id="PRO_0000048772"
FT DNA_BIND 8..76
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
SQ SEQUENCE 280 AA; 28796 MW; DA858428B29F1F47 CRC64;
MSKPVDHVKR PMNAFMVWSR AQRRKMAQEN PKMHNSEISK RLGAEWKLLS EAEKRPFIDE
AKRLRAMHMK EHPDYKYRPR RKPKTLLKKD KFAFPVPYGL GAVAEHEPPH GLKAAALHGG
AAGGLGPDSL LGNPEKAAAA AAAAAARVFF PQSAAAAAAA AAAAAAGGPY SLLDLGSKMA
EISSSSSAGS ALPYASSLGY PGAGGAGAFH GAAAAAAAAA AAAGGHTHSH PSPGNPGYMI
PCNCSAWPGP GLQPPLAYIL LPGMGKPQLD PYPAAYAAAL
