SOX21_MOUSE
ID SOX21_MOUSE Reviewed; 276 AA.
AC Q811W0; B9EJU0; Q8VH35;
DT 26-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Transcription factor SOX-21;
GN Name=Sox21;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND FUNCTION.
RC STRAIN=BALB/cJ; TISSUE=Brain;
RX PubMed=12446692; DOI=10.1074/jbc.m208780200;
RA Hwang C.K., Wu X., Wang G., Kim C.S., Loh H.H.;
RT "Mouse mu opioid receptor distal promoter transcriptional regulation by SOX
RT proteins.";
RL J. Biol. Chem. 278:3742-3750(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=BALB/cJ;
RA Uwanogho D.A.;
RL Submitted (DEC-2001) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May play a role as an activator of transcription of OPRM1.
CC Overexpression of SOX21 can up-regulate the OPRM1 distal promoter
CC activity in mor-expressing neuronal cells.
CC {ECO:0000269|PubMed:12446692}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
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DR EMBL; AY142959; AAN60055.1; -; mRNA.
DR EMBL; AY069926; AAL49967.1; -; mRNA.
DR EMBL; BC069176; AAH69176.1; -; mRNA.
DR EMBL; BC147556; AAI47557.1; -; mRNA.
DR EMBL; BC147565; AAI47566.1; -; mRNA.
DR CCDS; CCDS27334.1; -.
DR RefSeq; NP_808421.1; NM_177753.3.
DR AlphaFoldDB; Q811W0; -.
DR SMR; Q811W0; -.
DR BioGRID; 230133; 1.
DR STRING; 10090.ENSMUSP00000127396; -.
DR iPTMnet; Q811W0; -.
DR PhosphoSitePlus; Q811W0; -.
DR MaxQB; Q811W0; -.
DR PaxDb; Q811W0; -.
DR PRIDE; Q811W0; -.
DR ProteomicsDB; 261556; -.
DR Antibodypedia; 24798; 198 antibodies from 30 providers.
DR DNASU; 223227; -.
DR Ensembl; ENSMUST00000170662; ENSMUSP00000127396; ENSMUSG00000061517.
DR GeneID; 223227; -.
DR KEGG; mmu:223227; -.
DR UCSC; uc007uyt.2; mouse.
DR CTD; 11166; -.
DR MGI; MGI:2654070; Sox21.
DR VEuPathDB; HostDB:ENSMUSG00000061517; -.
DR eggNOG; KOG0527; Eukaryota.
DR GeneTree; ENSGT00940000162795; -.
DR HOGENOM; CLU_021123_3_1_1; -.
DR InParanoid; Q811W0; -.
DR OMA; SDSIMGH; -.
DR OrthoDB; 1335452at2759; -.
DR PhylomeDB; Q811W0; -.
DR TreeFam; TF351735; -.
DR BioGRID-ORCS; 223227; 0 hits in 74 CRISPR screens.
DR ChiTaRS; Sox21; mouse.
DR PRO; PR:Q811W0; -.
DR Proteomes; UP000000589; Chromosome 14.
DR RNAct; Q811W0; protein.
DR Bgee; ENSMUSG00000061517; Expressed in saccule of membranous labyrinth and 127 other tissues.
DR Genevisible; Q811W0; MM.
DR GO; GO:0005634; C:nucleus; IC:MGI.
DR GO; GO:0003677; F:DNA binding; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:MGI.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0042633; P:hair cycle; IMP:MGI.
DR GO; GO:0001942; P:hair follicle development; IMP:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IDA:MGI.
DR GO; GO:0043588; P:skin development; IMP:MGI.
DR GO; GO:0048863; P:stem cell differentiation; ISO:MGI.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR022097; SOX_fam.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12336; SOXp; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..276
FT /note="Transcription factor SOX-21"
FT /id="PRO_0000048771"
FT DNA_BIND 8..76
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT CONFLICT 21
FT /note="A -> G (in Ref. 2; AAL49967)"
FT /evidence="ECO:0000305"
FT CONFLICT 116
FT /note="G -> A (in Ref. 2; AAL49967)"
FT /evidence="ECO:0000305"
FT CONFLICT 178
FT /note="K -> R (in Ref. 2; AAL49967)"
FT /evidence="ECO:0000305"
FT CONFLICT 199
FT /note="T -> G (in Ref. 2; AAL49967)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 276 AA; 28610 MW; FDC886EDA5BF793A CRC64;
MSKPVDHVKR PMNAFMVWSR AQRRKMAQEN PKMHNSEISK RLGAEWKLLT ESEKRPFIDE
AKRLRAMHMK EHPDYKYRPR RKPKTLLKKD KFAFPVPYGL GSVADAEHPA LKAGAGLHAG
AGGGLVPESL LANPEKAAAA AAAAAARVFF PQSAAAAAAA AAAAAAGSPY SLLDLGSKMA
EISSSSSGLP YASSLGYPTA GAGAFHGAAA AAAAAAAAAG GHTHSHPSPG NPGYMIPCNC
SAWPSPGLQP PLAYILLPGM GKPQLDPYPA AYAAAL
