ID   SOX21_XENLA             Reviewed;         262 AA.
AC   B0ZTE1;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   08-APR-2008, sequence version 1.
DT   03-AUG-2022, entry version 56.
DE   RecName: Full=Transcription factor Sox-21 {ECO:0000303|PubMed:18956331};
DE   AltName: Full=SRY (sex determining region Y)-box 21;
GN   Name=sox21 {ECO:0000312|EMBL:ABY90180.1};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:ABY90180.1}
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], PUTATIVE FUNCTION, TISSUE SPECIFICITY,
RP   AND DEVELOPMENTAL STAGE.
RX   PubMed=18956331; DOI=10.1387/ijdb.082586dc;
RA   Cunningham D.D., Meng Z., Fritzsch B., Casey E.S.;
RT   "Cloning and developmental expression of the soxB2 genes, sox14 and sox21,
RT   during Xenopus laevis embryogenesis.";
RL   Int. J. Dev. Biol. 52:999-1004(2008).
CC   -!- FUNCTION: Acts as a negative regulator of transcription (By
CC       similarity). May function as a switch in neuronal development.
CC       {ECO:0000250|UniProtKB:Q9W7R5, ECO:0000269|PubMed:18956331}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC   -!- TISSUE SPECIFICITY: Expressed throughout the developing central nervous
CC       system, including the olfactory placodes, with strongest expression at
CC       the boundary between the midbrain and hindbrain.
CC       {ECO:0000269|PubMed:18956331}.
CC   -!- DEVELOPMENTAL STAGE: Expressed zygotically from stage 10 (early
CC       gastrula) to all subsequent embryonic stages.
CC       {ECO:0000269|PubMed:18956331}.
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DR   EMBL; EU403424; ABY90180.1; -; Genomic_DNA.
DR   RefSeq; NP_001165684.1; NM_001172213.1.
DR   AlphaFoldDB; B0ZTE1; -.
DR   SMR; B0ZTE1; -.
DR   GeneID; 100337612; -.
DR   KEGG; xla:100337612; -.
DR   CTD; 100337612; -.
DR   Xenbase; XB-GENE-6464309; sox21.S.
DR   OMA; SDSIMGH; -.
DR   OrthoDB; 1335452at2759; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 100337612; Expressed in zone of skin and 7 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0007399; P:nervous system development; IEP:UniProtKB.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR022097; SOX_fam.
DR   Pfam; PF00505; HMG_box; 1.
DR   Pfam; PF12336; SOXp; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..262
FT                   /note="Transcription factor Sox-21"
FT                   /id="PRO_0000378073"
FT   DNA_BIND        8..76
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
SQ   SEQUENCE   262 AA;  28118 MW;  E00EAE8B9362CE42 CRC64;
     MSKPLDHVKR PMNAFMVWSR AQRRKMAQEN PKMHNSEISK RLGAEWKLLT EAEKRPFIDE
     AKRLRAMHMK DHPDYKYRPR RKPKTLLKKD KFAFPMPYSL TGDHDGLKAV SLHGAGVLTD
     ALLCHPEKAA AAAAAAAARV FFQPSAAAAA AAAAAASGSS TNPYSLFDLS SKMAEMTHSS
     SSIPYTSSIG YPQSSGGAFA GVTGGGHTHS HPSPGNPGYM IPCNCTGWPS PGLQPPLAYI
     LFPGMGKPQL EPYPAAAYAA AL