SOX2_DANRE
ID SOX2_DANRE Reviewed; 315 AA.
AC Q6P0E1;
DT 30-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 119.
DE RecName: Full=Transcription factor Sox-2;
GN Name=sox2 {ECO:0000312|EMBL:AAH65656.1}; ORFNames=zgc:65860, zgc:77389;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAE48583.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC TISSUE=Embryo {ECO:0000269|PubMed:16408288};
RX PubMed=16408288; DOI=10.1002/dvdy.20678;
RA Okuda Y., Yoda H., Uchikawa M., Furutani-Seiki M., Takeda H., Kondoh H.,
RA Kamachi Y.;
RT "Comparative genomic and expression analysis of group B1 sox genes in
RT zebrafish indicates their diversification during vertebrate evolution.";
RL Dev. Dyn. 235:811-825(2006).
RN [2] {ECO:0000312|EMBL:AAH65656.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo {ECO:0000312|EMBL:AAH56743.1};
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX PubMed=16543359; DOI=10.1093/hmg/ddl064;
RA Williamson K.A., Hever A.M., Rainger J., Rogers R.C., Magee A., Fiedler Z.,
RA Keng W.T., Sharkey F.H., McGill N., Hill C.J., Schneider A., Messina M.,
RA Turnpenny P.D., Fantes J.A., van Heyningen V., Fitzpatrick D.R.;
RT "Mutations in SOX2 cause anophthalmia-esophageal-genital (AEG) syndrome.";
RL Hum. Mol. Genet. 15:1413-1422(2006).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=16324829; DOI=10.1016/j.mod.2005.10.005;
RA Cunliffe V.T., Casaccia-Bonnefil P.;
RT "Histone deacetylase 1 is essential for oligodendrocyte specification in
RT the zebrafish CNS.";
RL Mech. Dev. 123:24-30(2006).
CC -!- FUNCTION: Transcriptional activator. May function as a switch in
CC neuronal development (By similarity). Downstream SRRT target that
CC mediates the promotion of neural stem cell self-renewal (By
CC similarity). {ECO:0000250, ECO:0000269|PubMed:16408288}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267,
CC ECO:0000269|PubMed:16543359, ECO:0000305}. Cytoplasm
CC {ECO:0000269|PubMed:16543359}.
CC -!- TISSUE SPECIFICITY: At the shield stage, expressed uniformly in the
CC future ectoderm. At the 75-80% epiboly stage, becomes localized to the
CC presumptive neuroectoderm; strong expression in the presumptive
CC forebrain, weak expression in the presumptive spinal cord. At the tail
CC bud to 3-somite stage, expressed in distinct regions of the future
CC brain, the anterior margin of the neural plate and the future retina.
CC At the 12-somite stage, strong expression in the central nervous system
CC rostral to the hindbrain, including the optic vesicle. At the 21- to
CC 25-somite stage, strong expression in the retina, otic placode and
CC cerebellum. At 28-50 hours post-fertilization, restricted to the
CC ventricular zone of the hindbrain. At 5 days, expressed in the
CC esophageal endoderm. {ECO:0000269|PubMed:16324829,
CC ECO:0000269|PubMed:16408288, ECO:0000269|PubMed:16543359}.
CC -!- DEVELOPMENTAL STAGE: Expressed zygotically. First detected at the 30%
CC epiboly stage. {ECO:0000269|PubMed:16408288}.
CC -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC number of yeast and animal transcription factors.
CC {ECO:0000250|UniProtKB:P41225}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AB242329; BAE48583.1; -; mRNA.
DR EMBL; BC056743; AAH56743.1; -; mRNA.
DR EMBL; BC065656; AAH65656.1; -; mRNA.
DR RefSeq; NP_998283.1; NM_213118.1.
DR AlphaFoldDB; Q6P0E1; -.
DR SMR; Q6P0E1; -.
DR STRING; 7955.ENSDARP00000095266; -.
DR PaxDb; Q6P0E1; -.
DR Ensembl; ENSDART00000104493; ENSDARP00000095266; ENSDARG00000070913.
DR GeneID; 378723; -.
DR KEGG; dre:378723; -.
DR CTD; 6657; -.
DR ZFIN; ZDB-GENE-030909-1; sox2.
DR eggNOG; KOG0527; Eukaryota.
DR GeneTree; ENSGT00940000160614; -.
DR HOGENOM; CLU_021123_0_0_1; -.
DR InParanoid; Q6P0E1; -.
DR OMA; NMMETDL; -.
DR OrthoDB; 1161594at2759; -.
DR PhylomeDB; Q6P0E1; -.
DR TreeFam; TF351735; -.
DR Reactome; R-DRE-3769402; Deactivation of the beta-catenin transactivating complex.
DR PRO; PR:Q6P0E1; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 22.
DR Bgee; ENSDARG00000070913; Expressed in ear and 86 other tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IC:ZFIN.
DR GO; GO:0003682; F:chromatin binding; IDA:ZFIN.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:ZFIN.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0008283; P:cell population proliferation; IMP:ZFIN.
DR GO; GO:0021538; P:epithalamus development; IMP:ZFIN.
DR GO; GO:0048592; P:eye morphogenesis; IMP:ZFIN.
DR GO; GO:0031101; P:fin regeneration; IMP:ZFIN.
DR GO; GO:0030900; P:forebrain development; IBA:GO_Central.
DR GO; GO:0048839; P:inner ear development; IBA:GO_Central.
DR GO; GO:0060119; P:inner ear receptor cell development; IMP:ZFIN.
DR GO; GO:1905040; P:otic placode development; IMP:ZFIN.
DR GO; GO:0071599; P:otic vesicle development; IMP:ZFIN.
DR GO; GO:0021982; P:pineal gland development; IMP:ZFIN.
DR GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IDA:ZFIN.
DR GO; GO:0031099; P:regeneration; IMP:ZFIN.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR032643; SOX-2.
DR InterPro; IPR022097; SOX_fam.
DR PANTHER; PTHR10270:SF231; PTHR10270:SF231; 1.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12336; SOXp; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW Activator; Cytoplasm; Developmental protein; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..315
FT /note="Transcription factor Sox-2"
FT /id="PRO_0000238911"
FT DNA_BIND 38..106
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 235..263
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 296..315
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 270..278
FT /note="9aaTAD"
FT /evidence="ECO:0000250|UniProtKB:P41225"
FT COMPBIAS 14..37
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 315 AA; 34698 MW; E398DB33C43330EA CRC64;
MYNMMETELK PPAPQPNTGG TGNTNSSGNN QKNSPDRIKR PMNAFMVWSR GQRRKMAQEN
PKMHNSEISK RLGAEWKLLS ESEKRPFIDE AKRLRALHMK EHPDYKYRPR RKTKTLMKKD
KYTLPGGLLA PGGNGMGAGV GVGAGLGAGV NQRMDSYAHM NGWTNGGYGM MQEQLGYPQH
PSLNAHNTAQ MQPMHRYDMS ALQYNSMTNS QTYMNGSPTY SMSYSQQSTP GMTLGSMGSV
VKSESSSSPP VVTSSSHSRA GQCQTGDLRD MISMYLPGAE VQDQSAQSRL HMSQHYQSAP
VPGTTINGTI PLSHM
