ID   SOX2_XENTR              Reviewed;         311 AA.
AC   Q6NVN0;
DT   16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Transcription factor Sox-2 {ECO:0000250|UniProtKB:O42569};
DE   AltName: Full=SRY (sex determining region Y)-box 2;
GN   Name=sox2 {ECO:0000312|EMBL:AAH67975.1}; ORFNames=TNeu054c10.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1] {ECO:0000312|EMBL:CAJ82651.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula {ECO:0000312|EMBL:CAJ82651.1};
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000312|EMBL:CAJ82651.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo {ECO:0000312|EMBL:AAH67975.1};
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional activator. Functions as a switch in neuronal
CC       development, participating in the differentiation of embryonic
CC       neuroectodermal cells into neural tissues by making the ectodermal
CC       cells responsive to FGF-neuralizing signals (By similarity). Downstream
CC       SRRT target that mediates the promotion of neural stem cell self-
CC       renewal (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P48432,
CC       ECO:0000255|PROSITE-ProRule:PRU00267}.
CC   -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC       number of yeast and animal transcription factors.
CC       {ECO:0000250|UniProtKB:P41225}.
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DR   EMBL; CR760314; CAJ82651.1; -; mRNA.
DR   EMBL; BC067975; AAH67975.1; -; mRNA.
DR   RefSeq; NP_998869.1; NM_213704.3.
DR   AlphaFoldDB; Q6NVN0; -.
DR   SMR; Q6NVN0; -.
DR   STRING; 8364.ENSXETP00000032478; -.
DR   PaxDb; Q6NVN0; -.
DR   DNASU; 407873; -.
DR   GeneID; 407873; -.
DR   KEGG; xtr:407873; -.
DR   CTD; 6657; -.
DR   Xenbase; XB-GENE-484553; sox2.
DR   eggNOG; KOG0527; Eukaryota.
DR   HOGENOM; CLU_021123_0_0_1; -.
DR   InParanoid; Q6NVN0; -.
DR   OMA; NMMETDL; -.
DR   OrthoDB; 1161594at2759; -.
DR   PhylomeDB; Q6NVN0; -.
DR   TreeFam; TF351735; -.
DR   Reactome; R-XTR-3769402; Deactivation of the beta-catenin transactivating complex.
DR   Proteomes; UP000008143; Chromosome 5.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000036807; Expressed in neurula embryo and 9 other tissues.
DR   ExpressionAtlas; Q6NVN0; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0003682; F:chromatin binding; IEA:Ensembl.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR   GO; GO:0008283; P:cell population proliferation; IEA:Ensembl.
DR   GO; GO:0021538; P:epithalamus development; IEA:Ensembl.
DR   GO; GO:0048592; P:eye morphogenesis; IEA:Ensembl.
DR   GO; GO:0031101; P:fin regeneration; IEA:Ensembl.
DR   GO; GO:0030900; P:forebrain development; IBA:GO_Central.
DR   GO; GO:0048839; P:inner ear development; IBA:GO_Central.
DR   GO; GO:0060119; P:inner ear receptor cell development; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0007399; P:nervous system development; ISS:UniProtKB.
DR   GO; GO:1905040; P:otic placode development; IEA:Ensembl.
DR   GO; GO:0071599; P:otic vesicle development; IEA:Ensembl.
DR   GO; GO:0021982; P:pineal gland development; IEA:Ensembl.
DR   GO; GO:0051091; P:positive regulation of DNA-binding transcription factor activity; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR032643; SOX-2.
DR   InterPro; IPR022097; SOX_fam.
DR   PANTHER; PTHR10270:SF231; PTHR10270:SF231; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   Pfam; PF12336; SOXp; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Developmental protein; Differentiation; DNA-binding;
KW   Neurogenesis; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..311
FT                   /note="Transcription factor Sox-2"
FT                   /id="PRO_0000378065"
FT   DNA_BIND        37..105
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          232..259
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           266..274
FT                   /note="9aaTAD"
FT                   /evidence="ECO:0000250|UniProtKB:P41225"
FT   COMPBIAS        14..36
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        232..258
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   311 AA;  34089 MW;  E35529C4BB706FDA CRC64;
     MYNMMETDLK PPAPQQASGG NSNSGSNNQS KNSPDRVKRP MNAFMVWSRG QRRKMAQENP
     KMHNSEISKR LGAEWKLLSE AEKRPFIDEA KRLRALHMKE HPDYKYRPRR KTKTLMKKDK
     YTLPGGLLAP GANPMTSGVG ASLGAGVNQR MDTYAHMNGW TNGGYGMMQE QLGYPQHPGL
     SAHNAPQMQP MHRYDVSALQ YNSMSSSQTY MNGSPTYSMS YSQQGAPGMS LGSMGSVVKS
     ESSSSPPVVT SSSHSRAPCQ AGDLRDMISM YLPGAEVPEP AAQSRLHMSQ HYQSASVAGT
     AINGTLPLSH M