SOX30_MACFA
ID SOX30_MACFA Reviewed; 753 AA.
AC Q8WNV5; Q4R7T4;
DT 12-APR-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 25-MAY-2022, entry version 86.
DE RecName: Full=Transcription factor SOX-30;
GN Name=SOX30; ORFNames=QtsA-10245, QtsA-14427;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=12498619; DOI=10.1186/1471-2164-3-36;
RA Osada N., Hida M., Kusuda J., Tanuma R., Hirata M., Suto Y., Hirai M.,
RA Terao K., Sugano S., Hashimoto K.;
RT "Cynomolgus monkey testicular cDNAs for discovery of novel human genes in
RT the human genome sequence.";
RL BMC Genomics 3:36-36(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RG International consortium for macaque cDNA sequencing and analysis;
RT "DNA sequences of macaque genes expressed in brain or testis and its
RT evolutionary implications.";
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as both a transcriptional activator and repressor (By
CC similarity). Binds to the DNA sequence 5'-ACAAT-3' and shows a
CC preference for guanine residues surrounding this core motif (By
CC similarity). Binds to its own promoter and activates its own
CC transcription (By similarity). Required to activate the expression of
CC postmeiotic genes involved in spermiogenesis (By similarity). Binds to
CC the promoter region of CTNNB1 and represses its transcription which
CC leads to inhibition of Wnt signaling (By similarity). Also inhibits Wnt
CC signaling by binding to the CTNNB1 protein, preventing interaction of
CC CTNNB1 with TCF7L2/TCF4 (By similarity). {ECO:0000250|UniProtKB:O94993,
CC ECO:0000250|UniProtKB:Q8CGW4}.
CC -!- SUBUNIT: Interacts with CTNNB1, competitively inhibiting CTNNB1-
CC TCF7L2/TCF4 interaction. {ECO:0000250|UniProtKB:O94993}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC Cytoplasm {ECO:0000250|UniProtKB:O94993}. Note=Enriched at the
CC chromocenter. {ECO:0000250|UniProtKB:Q8CGW4}.
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DR EMBL; AB064989; BAB83531.1; -; mRNA.
DR EMBL; AB168728; BAE00838.1; -; mRNA.
DR RefSeq; XP_005558452.1; XM_005558395.2.
DR AlphaFoldDB; Q8WNV5; -.
DR SMR; Q8WNV5; -.
DR STRING; 9541.XP_005558452.1; -.
DR GeneID; 101925990; -.
DR KEGG; mcf:101925990; -.
DR CTD; 11063; -.
DR VEuPathDB; HostDB:ENSMFAG00000029536; -.
DR eggNOG; KOG0527; Eukaryota.
DR OMA; PFREYPD; -.
DR OrthoDB; 369754at2759; -.
DR Proteomes; UP000233100; Chromosome 6.
DR GO; GO:0010369; C:chromocenter; ISS:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISS:UniProtKB.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; ISS:UniProtKB.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0120211; P:proacrosomal vesicle fusion; ISS:UniProtKB.
DR GO; GO:0007286; P:spermatid development; ISS:UniProtKB.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW Activator; Cytoplasm; DNA-binding; Nucleus; Reference proteome; Repressor;
KW Transcription; Transcription regulation.
FT CHAIN 1..753
FT /note="Transcription factor SOX-30"
FT /id="PRO_0000048774"
FT DNA_BIND 337..405
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 140..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..540
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..753
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 753 AA; 82135 MW; F667A0E4C710C9C1 CRC64;
MERARPEPQP QQRPLRPAPP LLPVEGTTFW AAAVEPPPSP PTLSAAASAT LASSCGEAVA
SGLPPAVRRL LQVKPEQVLL LPQPQARDEE AAASPAQARL LQFRPDLRLL PPPSASEGAP
SRPELHPVQP RALHFKAKKQ ELGPGLDPSV GPRGGVETGP RASRVVKLEG PGPALAYFRG
NEKGKLEAEE VMRDAMKGGD GKSPAAIREG VIKTEEPERL LEDCRLDAEP ASNGLVHGSA
EVILAPTSGA FGPHQQDLRI PLTLHTVPPG ARIQFQGAPP SELIRLTKVP LTPVPIKMQS
LLEPSVKIET KDVPLTVLPS DAGIPDTPFS KDRNGHVKRP MNAFMVWARI HRPALAKANP
AANNAEISVQ LGLEWNKLSE EQKKPYYDEA QKIKEKHREE FPGWVYQPRP GKRKRFPLSV
SNVFSGTTQN IISTNPTTVY PYRSPTYSVV IPSLQNPITH PVGETSPAIQ LPTPAVQRPS
PVTLFQPSVS SAAQVAVQDP SLPLYPALPP QRFAGPSQTD THQLHSEGTH TVKQPTPVSL
ESTNRISNSA STAHARFATS TIQPPKEYSS VSPCPRSAPI PQASPIPHPH VYQPPPLGHP
ATLFGTPPRF SFHHPYFLPG PHYFPSSTCP YSRPPFGYGN FPSSMPECLG YYEDRYQKHE
AIFSALNRDY SFRDYSSERT HSENSRSCEN MNGTSFYNSH SHSGEEYLNP VPQLDIGALE
NVFTAPTSTP SSIQQVNVTD SDEEEEEKVL RDL
