ID   SOX3_CAEEL              Reviewed;         212 AA.
AC   Q20201;
DT   02-JUN-2021, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 146.
DE   RecName: Full=Transcription factor sox-3 {ECO:0000305};
GN   Name=sox-3 {ECO:0000312|WormBase:F40E10.2};
GN   ORFNames=F40E10.2 {ECO:0000312|WormBase:F40E10.2};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX   PubMed=26153233; DOI=10.1242/dev.125740;
RA   Vidal B., Santella A., Serrano-Saiz E., Bao Z., Chuang C.F., Hobert O.;
RT   "C. elegans SoxB genes are dispensable for embryonic neurogenesis but
RT   required for terminal differentiation of specific neuron types.";
RL   Development 142:2464-2477(2015).
CC   -!- FUNCTION: Probable transcription factor (PubMed:26153233). Involved in
CC       the terminal differentiation of some neuronal cell types
CC       (PubMed:26153233). Dispensable for neuronal fate commitment during
CC       embryogenesis (PubMed:26153233). {ECO:0000269|PubMed:26153233}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in several differentiated postmitotic
CC       neurons during embryogenesis, but not in neuroblasts (PubMed:26153233).
CC       Expressed in larvae and adults in sensory neurons ASK and OLQ, the SMB
CC       motor neurons, and the SAA neurons (PubMed:26153233).
CC       {ECO:0000269|PubMed:26153233}.
CC   -!- DISRUPTION PHENOTYPE: Expression of immunoglobulin superfamily adhesion
CC       molecules rig-5 and lad-2 is abolished in the dorsal and ventral SAA
CC       neurons, while expression of the neuropeptide flp-7 gene is lost in the
CC       dorsal SAA subtype but remains unaffected in the ventral SAA subtype
CC       (PubMed:26153233). No effect on the number of rab-3 expressing neurons
CC       on a sox-2 mutant background (PubMed:26153233).
CC       {ECO:0000269|PubMed:26153233}.
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DR   EMBL; BX284606; CAA93665.1; -; Genomic_DNA.
DR   PIR; T22022; T22022.
DR   RefSeq; NP_510439.1; NM_078038.1.
DR   AlphaFoldDB; Q20201; -.
DR   SMR; Q20201; -.
DR   IntAct; Q20201; 9.
DR   STRING; 6239.F40E10.2; -.
DR   PaxDb; Q20201; -.
DR   EnsemblMetazoa; F40E10.2.1; F40E10.2.1; WBGene00004950.
DR   EnsemblMetazoa; F40E10.2.2; F40E10.2.2; WBGene00004950.
DR   GeneID; 185534; -.
DR   KEGG; cel:CELE_F40E10.2; -.
DR   UCSC; F40E10.2; c. elegans.
DR   CTD; 185534; -.
DR   WormBase; F40E10.2; CE05838; WBGene00004950; sox-3.
DR   eggNOG; KOG0527; Eukaryota.
DR   GeneTree; ENSGT00940000160614; -.
DR   HOGENOM; CLU_094362_0_0_1; -.
DR   InParanoid; Q20201; -.
DR   OMA; YNMMAAY; -.
DR   OrthoDB; 1368951at2759; -.
DR   PhylomeDB; Q20201; -.
DR   Reactome; R-CEL-3769402; Deactivation of the beta-catenin transactivating complex.
DR   SignaLink; Q20201; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00004950; Expressed in pharyngeal muscle cell (C elegans) and 30 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0043565; F:sequence-specific DNA binding; ISS:WormBase.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0030182; P:neuron differentiation; IMP:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   Pfam; PF00505; HMG_box; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..212
FT                   /note="Transcription factor sox-3"
FT                   /id="PRO_0000452694"
FT   DNA_BIND        48..116
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
SQ   SEQUENCE   212 AA;  23770 MW;  4742ADBA9B2270E0 CRC64;
     MTDLSCLYPS LLCTEAAKTS YDEDTTSVSS GLSPPGSPVD LQNSLDHVKR PMNAFMVWSR
     GQRRKMAQDN PKMHNSEISK RLGAEWKQLS EQEKRPFIDE AKRLRALHMK EHPDYKYRPR
     RKPKSSNLKQ QPRLNIAMPT IPPQSLFNYS TAFDSLKTHD LSQYYSSFFQ SPVLSGSTYA
     PYNMMAAYAR QAAAVAAASQ VSASTTPTAP AT