ID   SOX3_CHICK              Reviewed;         312 AA.
AC   P48433;
DT   01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1996, sequence version 1.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Transcription factor SOX-3;
DE            Short=cSox3;
GN   Name=SOX3;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PUTATIVE FUNCTION, TISSUE SPECIFICITY, AND
RP   DEVELOPMENTAL STAGE.
RC   TISSUE=Embryo;
RX   PubMed=7748786; DOI=10.1016/0925-4773(94)00299-3;
RA   Uwanogho D., Rex M., Cartwright E.J., Pearl G., Healy C., Scotting P.J.,
RA   Sharpe P.T.;
RT   "Embryonic expression of the chicken Sox2, Sox3 and Sox11 genes suggests an
RT   interactive role in neuronal development.";
RL   Mech. Dev. 49:23-36(1995).
RN   [2]
RP   FUNCTION.
RX   PubMed=14517545; DOI=10.1038/nn1131;
RA   Bylund M., Andersson E., Novitch B.G., Muhr J.;
RT   "Vertebrate neurogenesis is counteracted by Sox1-3 activity.";
RL   Nat. Neurosci. 6:1162-1168(2003).
CC   -!- FUNCTION: Transcription factor that may function as a switch in
CC       neuronal development. Keeps neural cells undifferentiated by
CC       counteracting the activity of proneural proteins and suppresses
CC       neuronal differentiation. {ECO:0000269|PubMed:14517545}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- TISSUE SPECIFICITY: First expressed in the embryonic neural plate
CC       shortly before closure and expression continues in the neural tube.
CC       From stage 16 onwards, expressed throughout the CNS including the
CC       brain, with expression predominant in the undifferentiated cells of the
CC       neural epithelium. Also expressed at a low level in the retina and the
CC       gut epithelium. {ECO:0000269|PubMed:7748786}.
CC   -!- DEVELOPMENTAL STAGE: Expression is maximal at stages 24-31, then begins
CC       to decline. Expression is absent by stage 37. Does not appear to be
CC       expressed in adults. {ECO:0000269|PubMed:7748786}.
CC   -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC       number of yeast and animal transcription factors.
CC       {ECO:0000250|UniProtKB:P41225}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-4 is the initiator.
CC       {ECO:0000305}.
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DR   EMBL; U12467; AAA76598.1; -; mRNA.
DR   PIR; I50705; I50705.
DR   AlphaFoldDB; P48433; -.
DR   SMR; P48433; -.
DR   VEuPathDB; HostDB:geneid_374019; -.
DR   InParanoid; P48433; -.
DR   PhylomeDB; P48433; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISS:UniProtKB.
DR   GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0060324; P:face development; ISS:UniProtKB.
DR   GO; GO:0021854; P:hypothalamus development; ISS:UniProtKB.
DR   GO; GO:0045665; P:negative regulation of neuron differentiation; IMP:UniProtKB.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0021983; P:pituitary gland development; ISS:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0007423; P:sensory organ development; ISS:UniProtKB.
DR   Gene3D; 1.10.30.10; -; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   InterPro; IPR029550; SOX-3.
DR   InterPro; IPR022097; SOX_fam.
DR   PANTHER; PTHR10270:SF111; PTHR10270:SF111; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   Pfam; PF12336; SOXp; 1.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; SSF47095; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..312
FT                   /note="Transcription factor SOX-3"
FT                   /id="PRO_0000048722"
FT   DNA_BIND        46..114
FT                   /note="HMG box"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          229..254
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           263..274
FT                   /note="9aaTAD"
FT                   /evidence="ECO:0000250|UniProtKB:P41225"
SQ   SEQUENCE   312 AA;  34456 MW;  44A21E7DDCBFB787 CRC64;
     MYSMLETEIK TPQPTRAARG EPARAATAKV GGAAAADGCR SDQDRVKRPM NAFMVWSRGQ
     RRKMAQENPK MHNSEISKRL GADWKLLSDA EKRPFIDEAK RLRAVHMKEY PDYKYRPRRK
     TKTLLKKDKY SLPGNLWPPG SAGAAAVGVG QRIDTYAHMN GWTNGAYSLM QDQLGYGQHP
     GMNSPQLQQM HRYDMPGLQY SPMMSTAQTY MNAGLHLQHV PRPYGQQPST AMSLGSMGSV
     VKSEPSSAPP AITSHSQRAC LGELRDMISM YLGPGGDATH PSALQGSRLH SVHQHYQSAG
     TRVNGTVPLT HI