SOX6_XENTR
ID SOX6_XENTR Reviewed; 777 AA.
AC B1H349;
DT 16-JUN-2009, integrated into UniProtKB/Swiss-Prot.
DT 29-APR-2008, sequence version 1.
DT 03-AUG-2022, entry version 69.
DE RecName: Full=Transcription factor Sox-6 {ECO:0000305};
GN Name=sox6 {ECO:0000250|UniProtKB:P35712};
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000312|EMBL:AAI61247.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=TGA IC {ECO:0000312|EMBL:AAI61247.1};
RC TISSUE=Bone {ECO:0000312|EMBL:AAI61247.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Transcription factor that plays a key role in several
CC developmental processes, including neurogenesis, chondrocytes
CC differentiation and cartilage formation. Specifically binds the 5'-
CC AACAAT-3' DNA motif present in enhancers and super-enhancers and
CC promotes expression of genes important for chondrogenesis. Required for
CC overt chondrogenesis when condensed prechondrocytes differentiate into
CC early stage chondrocytes: sox5 and sox6 cooperatively bind with sox9 on
CC active enhancers and super-enhancers associated with cartilage-specific
CC genes, and thereby potentiate sox9's ability to transactivate. Not
CC involved in precartilaginous condensation, the first step in
CC chondrogenesis, during which skeletal progenitors differentiate into
CC prechondrocytes. Binds to the proximal promoter region of the myelin
CC protein MPZ gene, and is thereby involved in the differentiation of
CC oligodendroglia in the developing spinal tube.
CC {ECO:0000250|UniProtKB:P40645}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P35712,
CC ECO:0000255|PROSITE-ProRule:PRU00267}.
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DR EMBL; BC161247; AAI61247.1; -; mRNA.
DR RefSeq; NP_001116887.1; NM_001123415.1.
DR AlphaFoldDB; B1H349; -.
DR SMR; B1H349; -.
DR STRING; 8364.ENSXETP00000035030; -.
DR PaxDb; B1H349; -.
DR GeneID; 100144640; -.
DR KEGG; xtr:100144640; -.
DR CTD; 55553; -.
DR Xenbase; XB-GENE-483934; sox6.
DR eggNOG; KOG0528; Eukaryota.
DR InParanoid; B1H349; -.
DR OrthoDB; 465521at2759; -.
DR Reactome; R-XTR-3769402; Deactivation of the beta-catenin transactivating complex.
DR Proteomes; UP000008143; Chromosome 4.
DR Proteomes; UP000790000; Unplaced.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0001502; P:cartilage condensation; ISS:UniProtKB.
DR GO; GO:0051216; P:cartilage development; ISS:UniProtKB.
DR GO; GO:0045165; P:cell fate commitment; IBA:GO_Central.
DR GO; GO:0007417; P:central nervous system development; IBA:GO_Central.
DR GO; GO:0002062; P:chondrocyte differentiation; ISS:UniProtKB.
DR GO; GO:0032332; P:positive regulation of chondrocyte differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR027153; SOX-6.
DR PANTHER; PTHR45789:SF1; PTHR45789:SF1; 2.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; Differentiation; DNA-binding;
KW Isopeptide bond; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..777
FT /note="Transcription factor Sox-6"
FT /id="PRO_0000378067"
FT DNA_BIND 570..638
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 1..33
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 92..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 342..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 701..777
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..33
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..368
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 394..424
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 701..734
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 747..762
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 777 AA; 86396 MW; 2C35C0A0C710850D CRC64;
MSSKQAASPF TCKAEGEEEM TGDLASREMN ECKDQIMASH LPLHPLNHNK PHSEELQSLV
TTLPADLDWD SMISSQHRMD SESNKLRSLY SFRTSSTSPH KPDEGARERS DLMSSVNFGT
PERRKGSLAD VVDSLKQKKL EEMTRSEQED STCVEKILSK DWKDKMDRLN TSELLGEIKG
TPESLAEKER QLSTMITQLI SLREQLLAAH DEQKKLAASQ IEKQRQQMDL ARQQQEQIAR
QQQQLLQQQH KINILQQQIQ VQGHMPPLMI PIFPHDQRTL AAAAAAQQGF LFPPGLSYKP
GDNYPMQFIP STMAAAAASG LSPLQLQQLY AAQLASMQVS PGAKIPTTPQ PANAPGTLSP
TGMKSEKRGT SPVAQIKDEA AQPLNLSARP KTADPIKSPT SPTQSFFPMS KTSPVSLSNK
SGIPSPIRGP SLDILSSLNS PALFGDQDTV MKAIQEARKM REQIQREQLL TPHSIDGKLP
INNMGLNNCR SDKMLLDAVT GKICIRSAHT ERTHFENLGP QLTGKPNEDG KLGPGVIDLT
RPEDVEGGAT VVEARVYRDT RGRSSSEPHI KRPMNAFMVW AKDERRKILQ AFPDMHNSNI
SKILGSRWKA MSNQEKQPYY EEQARLSKIH LEKYPNYKYK PRPKRTCIVD GKKLRIGEYK
QLMRSRRQEM RQFFTVGQQP QIPISTPTGV VYPGTISMAT TTPSPQMTSD CSSTSASPEP
SIPVIQSTYG MKLDSGSLGG NDLMNGEDEM EMYDDFEDDP KSDYSSDNEA NEAVSAN
