SOX7_XENLA
ID SOX7_XENLA Reviewed; 362 AA.
AC O42342;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Transcription factor Sox-7;
DE Short=xSOX7;
GN Name=sox7;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1] {ECO:0000305, ECO:0000312|EMBL:BAA22513.1}
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY, AND DEVELOPMENTAL
RP STAGE.
RC TISSUE=Ovary {ECO:0000312|EMBL:BAA22513.1};
RX PubMed=8950180; DOI=10.1016/s0167-4781(96)00145-5;
RA Shiozawa M., Hiraoka Y., Komatsu N., Ogawa M., Sakai Y., Aiso S.;
RT "Cloning and characterization of Xenopus laevis xSox7 cDNA.";
RL Biochim. Biophys. Acta 1309:73-76(1996).
RN [2] {ECO:0000305}
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=14678825; DOI=10.1016/j.modgep.2003.08.003;
RA Fawcett S.R., Klymkowsky M.W.;
RT "Embryonic expression of Xenopus laevis SOX7.";
RL Gene Expr. Patterns 4:29-33(2004).
RN [3] {ECO:0000305}
RP FUNCTION, AND INDUCTION.
RX PubMed=15680368; DOI=10.1016/j.ydbio.2004.11.008;
RA Zhang C., Basta T., Fawcett S.R., Klymkowsky M.W.;
RT "SOX7 is an immediate-early target of VegT and regulates Nodal-related gene
RT expression in Xenopus.";
RL Dev. Biol. 278:526-541(2005).
RN [4] {ECO:0000305}
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=16193513; DOI=10.1002/dvdy.20565;
RA Zhang C., Basta T., Klymkowsky M.W.;
RT "SOX7 and SOX18 are essential for cardiogenesis in Xenopus.";
RL Dev. Dyn. 234:878-891(2005).
RN [5] {ECO:0000305}
RP FUNCTION.
RX PubMed=17608734; DOI=10.1111/j.1432-0436.2007.00190.x;
RA Zhang C., Klymkowsky M.W.;
RT "The Sox axis, Nodal signaling, and germ layer specification.";
RL Differentiation 75:536-545(2007).
CC -!- FUNCTION: Transcription factor. Binds to the DNA sequence 5'-AACAAT-3'.
CC Acts downstream of vegt and upstream of nodal signaling to promote
CC endodermal and mesodermal differentiation by promoting vegt-induced
CC expression of both endodermal genes (including endodermin) and
CC mesodermal genes (including snai1/snail and snai2/slug). Induces
CC expression of multiple nodal genes (including nodal, nodal2, nodal4,
CC nodal5 and nodal6) and binds directly to sites within the promoter of
CC the nodal5 gene. The endodermal and mesodermal specification pathways
CC then interact to initiate cardiogenesis. Acts partially redundantly
CC with sox18 during cardiogenesis. Also acts as an antagonist of beta-
CC catenin signaling. Regulates (possibly indirectly) development of the
CC pronephros, the functional larval kidney.
CC {ECO:0000250|UniProtKB:Q28GD5, ECO:0000269|PubMed:15680368,
CC ECO:0000269|PubMed:16193513, ECO:0000269|PubMed:17608734,
CC ECO:0000269|PubMed:8950180}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Localized to the vegetal hemisphere of blastula
CC embryos. Tissue-specific expression in early neurula (stage 13-14)
CC embryos begins in the ciliate cells of the epidermis. Starting about
CC stage 24, expression is found in a lateral stripe on each side of the
CC embryo, with expression extending more posteriorly as development
CC proceeds. Expressed in embryonic vasculature, as well as in the
CC procardia tube, endocardium, notochord and hindbrain. As development
CC proceeds, strong expression is seen in the hindbrain, posterior
CC cardinal veins, aortic arch, stomodeal depression, epithelium and
CC intersomitic arteries of stage 33/34 larvae. Expressed in posterior
CC rhombomeres. By stage 40 larvae, expression in most of the vascular
CC endothelia disappears, in particular in the posterior cardinal vein,
CC but expression continues in the hindbrain. Expressed in a wide range of
CC adult tissues, including ovary, testis, kidney, bladder, duodenum and
CC liver. {ECO:0000269|PubMed:14678825, ECO:0000269|PubMed:16193513,
CC ECO:0000269|PubMed:8950180}.
CC -!- DEVELOPMENTAL STAGE: Expressed both maternally and zygotically.
CC Expressed in oocytes, eggs, throughout early embryonic development, and
CC in adults. {ECO:0000269|PubMed:14678825, ECO:0000269|PubMed:8950180}.
CC -!- INDUCTION: By maternal vegt. {ECO:0000269|PubMed:15680368}.
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DR EMBL; D83649; BAA22513.1; -; mRNA.
DR RefSeq; NP_001079337.1; NM_001085868.1.
DR AlphaFoldDB; O42342; -.
DR SMR; O42342; -.
DR GeneID; 378665; -.
DR KEGG; xla:378665; -.
DR CTD; 378665; -.
DR Xenbase; XB-GENE-865761; sox7.L.
DR OMA; HRTPVDK; -.
DR OrthoDB; 1042753at2759; -.
DR Proteomes; UP000186698; Chromosome 5L.
DR Bgee; 378665; Expressed in camera-type eye and 19 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:UniProtKB.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0001706; P:endoderm formation; IMP:UniProtKB.
DR GO; GO:0007507; P:heart development; IMP:UniProtKB.
DR GO; GO:0030178; P:negative regulation of Wnt signaling pathway; IMP:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR GO; GO:0048793; P:pronephros development; ISS:UniProtKB.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR033392; Sox7/17/18_central.
DR InterPro; IPR021934; Sox_C.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12067; Sox17_18_mid; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
DR PROSITE; PS51516; SOX_C; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; Differentiation; DNA-binding; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..362
FT /note="Transcription factor Sox-7"
FT /id="PRO_0000371504"
FT DOMAIN 246..362
FT /note="Sox C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00849"
FT DNA_BIND 42..110
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 19..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 27..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 362 AA; 40875 MW; 4303B8A5A243FEEB CRC64;
MTTLMGSYSW TESLDCSPMD GDLSDGLSPH RSPREKGSET RIRRPMNAFM VWAKDERKRL
AVQNPDLHNA ELSKMLGKSW KALSPAQKRP YVEEAERLRV QHMQDYPNYK YRPRRKKQIK
RICKRVDTGF LLGSLSKDQN SVPDTRGCRT AMEKEENGGY PGAALSDIRH YRETPSNGNK
YDQTYPYGLP TPPEMSPLEA IDQDQSFYST SCSEDCHSHI NGAVYPPEYS RSPILCSHLS
QVPIPQPGSS MIPPVPTCPP AYYSSSYHSI HNYHAHLGQL SPPPEHPHYD TIDQISQAEL
LGEMDRNEFD QYLNTSLQDP TEMTIHGHVQ VSQASDIQPS ETSLISVLAD ATATYYNSYS
VS
