SOX7_XENTR
ID SOX7_XENTR Reviewed; 362 AA.
AC Q28GD5;
DT 14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT 04-APR-2006, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Transcription factor Sox-7;
GN Name=sox7 {ECO:0000312|EMBL:CAJ82258.1}; ORFNames=TEgg131e23.1;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1] {ECO:0000312|EMBL:CAJ82258.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Egg {ECO:0000312|EMBL:CAJ82258.1};
RG Sanger Xenopus tropicalis EST/cDNA project;
RL Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|EMBL:CAJ82258.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Gastrula {ECO:0000312|EMBL:AAI70859.1};
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (NOV-2008) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP FUNCTION, AND TISSUE SPECIFICITY.
RX PubMed=18472403; DOI=10.1016/j.mod.2008.03.001;
RA Kyuno J., Masse K., Jones E.A.;
RT "A functional screen for genes involved in Xenopus pronephros
RT development.";
RL Mech. Dev. 125:571-586(2008).
CC -!- FUNCTION: Transcription factor. Binds to the DNA sequence 5'-AACAAT-3'.
CC Acts downstream of vegt and upstream of nodal signaling to promote
CC endodermal and mesodermal differentiation by promoting vegt-induced
CC expression of both endodermal genes (including endodermin) and
CC mesodermal genes (including snai1/snail and snai2/slug). Induces
CC expression of multiple nodal genes (including nodal, nodal2, nodal4,
CC nodal5 and nodal6) and binds directly to sites within the promoter of
CC the nodal5 gene. The endodermal and mesodermal specification pathways
CC then interact to initiate cardiogenesis. Acts partially redundantly
CC with sox18 during cardiogenesis. Also acts as an antagonist of beta-
CC catenin signaling (By similarity). Regulates (possibly indirectly)
CC development of the pronephros, the functional larval kidney.
CC {ECO:0000250|UniProtKB:O42342, ECO:0000269|PubMed:18472403}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:O42342,
CC ECO:0000255|PROSITE-ProRule:PRU00267}.
CC -!- TISSUE SPECIFICITY: Expressed in the embryonic pronephric sinus as well
CC as posterior cardinal veins. {ECO:0000269|PubMed:18472403}.
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DR EMBL; CR761431; CAJ82258.1; -; mRNA.
DR EMBL; BC170859; AAI70859.1; -; mRNA.
DR RefSeq; NP_001016326.1; NM_001016326.2.
DR AlphaFoldDB; Q28GD5; -.
DR SMR; Q28GD5; -.
DR STRING; 8364.ENSXETP00000001530; -.
DR PaxDb; Q28GD5; -.
DR Ensembl; ENSXETT00000001530; ENSXETP00000001530; ENSXETG00000000693.
DR GeneID; 549080; -.
DR KEGG; xtr:549080; -.
DR CTD; 83595; -.
DR Xenbase; XB-GENE-488067; sox7.
DR eggNOG; KOG0527; Eukaryota.
DR HOGENOM; CLU_044994_0_0_1; -.
DR InParanoid; Q28GD5; -.
DR OMA; ESFECPG; -.
DR OrthoDB; 1042753at2759; -.
DR PhylomeDB; Q28GD5; -.
DR Reactome; R-XTR-3769402; Deactivation of the beta-catenin transactivating complex.
DR Proteomes; UP000008143; Chromosome 5.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000000693; Expressed in olfactory system and 23 other tissues.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; ISS:UniProtKB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISS:UniProtKB.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IBA:GO_Central.
DR GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR GO; GO:0001706; P:endoderm formation; ISS:UniProtKB.
DR GO; GO:0007507; P:heart development; ISS:UniProtKB.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0048793; P:pronephros development; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.30.10; -; 1.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR InterPro; IPR033392; Sox7/17/18_central.
DR InterPro; IPR021934; Sox_C.
DR Pfam; PF00505; HMG_box; 1.
DR Pfam; PF12067; Sox17_18_mid; 1.
DR SMART; SM00398; HMG; 1.
DR SUPFAM; SSF47095; SSF47095; 1.
DR PROSITE; PS50118; HMG_BOX_2; 1.
DR PROSITE; PS51516; SOX_C; 1.
PE 2: Evidence at transcript level;
KW Activator; Developmental protein; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..362
FT /note="Transcription factor Sox-7"
FT /id="PRO_0000370246"
FT DOMAIN 245..362
FT /note="Sox C-terminal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00849"
FT DNA_BIND 42..110
FT /note="HMG box"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 21..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..41
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 362 AA; 40948 MW; A2B2F7754CC8EAC1 CRC64;
MTTLMGSYSW TEGLDCSPID EDLSDGLSPH RSPREKGSET RIRRPMNAFM VWAKDERKRL
AVQNPDLHNA ELSKMLGKSW KALSPAQKRP YVEEAERLRV QHMQDYPNYK YRPRRKKQIK
RICKRVDTGF LLSSLSRDQN SVPDTRGCRT AVEKEENGGY PGSALPDMRH YRETPSNGSK
HDQTYPYGLP TPPEMSPLEA IDQDQSFYST PCSEDCHPHI NGAVYEYSSR SPILCSHLSQ
VPIPQTGSSM IPPVPNCPPA YYSSTYHSIH HNYHAHLGQL SPPPEHPHYD AIDQISQAEL
LGDMDRNEFD QYLNTSLHDP SEMTIHGHVQ VSQASDIQPS ETSLISVLAD ATATYYNSYS
VS
